{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:44:48Z","timestamp":1793119488595,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ijcard.2024.131815","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T19:15:38Z","timestamp":1706123738000},"page":"131815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Comparison of the clinical chemistry score to other biomarker algorithms for rapid rule-out of acute myocardial infarction and risk stratification in patients with suspected acute coronary syndrome"],"prefix":"10.1016","volume":"400","author":[{"given":"Mustafa","family":"Yildirim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Salbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Ruth","family":"Milles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Biener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Giannitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mueller-Hennessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.ijcard.2024.131815_bb0005","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/j.jacc.2014.09.017","article-title":"2014 AHA\/ACC guideline for the Management of Patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"64","author":"Amsterdam","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2024.131815_bb0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"40","author":"Thygesen","year":"2019","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.ijcard.2024.131815_bb0015","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/eurheartj\/ehr492","article-title":"High-sensitive troponin T measurements: what do we gain and what are the challenges?","volume":"33","author":"Twerenbold","year":"2012","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.ijcard.2024.131815_bb0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF03086144","article-title":"Chest pain in the emergency room: value of the HEART score","volume":"16","author":"Six","year":"2008","journal-title":"Neth. Hear. J."},{"issue":"2","key":"10.1016\/j.ijcard.2024.131815_bb0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.annemergmed.2011.07.026","article-title":"Development of a clinical prediction rule for 30-day cardiac events in emergency department patients with chest pain and possible acute coronary syndrome","volume":"59","author":"Hess","year":"2012","journal-title":"Ann. Emerg. Med."},{"issue":"1","key":"10.1016\/j.ijcard.2024.131815_bb0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/1742-6723.12164","article-title":"Development and validation of the emergency department assessment of chest pain score and 2 h accelerated diagnostic protocol","volume":"26","author":"Than","year":"2014","journal-title":"Emerg. Med. Australas."},{"issue":"13","key":"10.1016\/j.ijcard.2024.131815_bb0035","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jacc.2011.06.026","article-title":"Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay","volume":"58","author":"Body","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2024.131815_bb0040","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.ijcard.2013.06.049","article-title":"Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin","volume":"168","author":"Rubini Gimenez","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2024.131815_bb0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.annemergmed.2015.11.013","article-title":"Multicenter evaluation of a 0-hour\/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T","volume":"68","author":"Mueller","year":"2016","journal-title":"Ann. Emerg. Med."},{"issue":"26","key":"10.1016\/j.ijcard.2024.131815_bb0050","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1056\/NEJMoa1803377","article-title":"Application of high-sensitivity troponin in suspected myocardial infarction","volume":"380","author":"Neumann","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.ijcard.2024.131815_bb0055","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1373\/clinchem.2017.271361","article-title":"Total analytic error for low cardiac troponin concentrations (<\/=10 ng\/L) by use of a high-sensitivity cardiac troponin assay","volume":"63","author":"Kavsak","year":"2017","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.ijcard.2024.131815_bb0060","doi-asserted-by":"crossref","DOI":"10.9778\/cmajo.20200047","article-title":"Using the clinical chemistry score in the emergency department to detect adverse cardiac events: a diagnostic accuracy study","volume":"8","author":"Kavsak","year":"2020","journal-title":"CMAJ Open"},{"issue":"33","key":"10.1016\/j.ijcard.2024.131815_bb0065","doi-asserted-by":"crossref","DOI":"10.1503\/cmaj.180144","article-title":"Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department","volume":"190","author":"Kavsak","year":"2018","journal-title":"CMAJ."},{"issue":"2","key":"10.1016\/j.ijcard.2024.131815_bb0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1373\/jalm.2019.029512","article-title":"A multicenter assessment of the sensitivity and specificity for a single high-sensitivity cardiac troponin test at emergency department presentation for hospital admission","volume":"4","author":"Kavsak","year":"2019","journal-title":"J. Appl. Lab. Med."},{"key":"10.1016\/j.ijcard.2024.131815_bb0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clinbiochem.2021.02.006","article-title":"External validation of the clinical chemistry score","volume":"91","author":"Wildi","year":"2021","journal-title":"Clin. Biochem."},{"issue":"14","key":"10.1016\/j.ijcard.2024.131815_bb0080","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ijcard.2024.131815_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1373\/clinchem.2011.171827","article-title":"Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome","volume":"58","author":"Mueller","year":"2012","journal-title":"Clin. Chem."},{"issue":"2","key":"10.1016\/j.ijcard.2024.131815_bb0090","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin. Chem."},{"issue":"9\u201310","key":"10.1016\/j.ijcard.2024.131815_bb0095","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cca.2010.12.034","article-title":"Multicenter analytical evaluation of a high-sensitivity troponin T assay","volume":"412","author":"Saenger","year":"2011","journal-title":"Clin. Chim. Acta"},{"issue":"19","key":"10.1016\/j.ijcard.2024.131815_bb0100","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jacc.2010.01.029","article-title":"Copeptin improves early diagnosis of acute myocardial infarction","volume":"55","author":"Keller","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2024.131815_bb0105","series-title":"Copeptin ProAVP Kryptor Product Sheet","author":"BRAHMS","year":"2015"},{"issue":"7","key":"10.1016\/j.ijcard.2024.131815_bb0110","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/hrt.2005.073122","article-title":"Validity of the GRACE (global registry of acute coronary events) acute coronary syndrome prediction model for six month post-discharge death in an independent data set","volume":"92","author":"Bradshaw","year":"2006","journal-title":"Heart."},{"issue":"19","key":"10.1016\/j.ijcard.2024.131815_bb0115","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1001\/archinte.163.19.2345","article-title":"Predictors of hospital mortality in the global registry of acute coronary events","volume":"163","author":"Granger","year":"2003","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.ijcard.2024.131815_bb0120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ijcard.2012.09.171","article-title":"What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the emergency department?: a clinical survey","volume":"166","author":"Than","year":"2013","journal-title":"Int. J. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324001803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324001803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T21:05:49Z","timestamp":1759093549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527324001803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":24,"alternative-id":["S0167527324001803"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.131815","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the clinical chemistry score to other biomarker algorithms for rapid rule-out of acute myocardial infarction and risk stratification in patients with suspected acute coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.131815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"131815"}}