{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:52:03Z","timestamp":1784029923237,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ijcard.2024.132203","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:33:28Z","timestamp":1716489208000},"page":"132203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction"],"prefix":"10.1016","volume":"409","author":[{"given":"Giuseppe","family":"Vergaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Del Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Carecci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Fu","family":"Ferrari Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Aimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Forini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kusmic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Faita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Tata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Musetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Burchielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2024.132203_bb0005","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archinte.1993.00410080011002","article-title":"Tissue renin-angiotensin system in myocardial hypertrophy and failure","volume":"153","author":"Dzau","year":"1993","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ijcard.2024.132203_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/clpt.2013.135","article-title":"Renin-angiotensin-aldosterone system inhibitors in heart failure","volume":"94","author":"Shearer","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2024.132203_bb0015","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cardfail.2010.06.417","article-title":"Val-Heft investigators. Plasma renin activity predicts adverse outcome in chronic heart failure, independently of pharmacologic therapy: data from the valsartan heart failure trial (Val-HeFT)","volume":"16","author":"Masson","year":"2010","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0020","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.amjcard.2011.03.034","article-title":"Prognostic value of plasma renin activity in heart failure","volume":"108","author":"Vergaro","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0025","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijcard.2012.03.061","article-title":"Prognostic value of plasma renin activity in heart failure patients with chronic kidney disease","volume":"167","author":"Poletti","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ejheart.2004.04.013","article-title":"The clinical implications of aldosterone escape in congestive heart failure","volume":"6","author":"Struthers","year":"2004","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0035","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2459\/JCM.0000000000000156","article-title":"Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism","volume":"16","author":"Vergaro","year":"2015","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"key":"10.1016\/j.ijcard.2024.132203_bb0040","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HYPERTENSIONAHA.115.06161","article-title":"Inhibition of Galectin-3 pathway prevents isoproterenol-induced left ventricular dysfunction and fibrosis in mice","volume":"67","author":"Vergaro","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2024.132203_bb0045","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jchf.2014.09.001","article-title":"Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure","volume":"2","author":"Vardeny","year":"2014","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0050","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2024.132203_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/bj2910083","article-title":"Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11","volume":"291","author":"Kenny","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijcard.2024.132203_bb0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/jmbi.1999.3492","article-title":"Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon","volume":"296","author":"Oefner","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCHEARTFAILURE.114.001785","article-title":"Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy","volume":"8","author":"von Lueder","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0070","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/ajh\/hpv015","article-title":"LCZ696, angiotensin II receptor-Neprilysin inhibitor, ameliorates high-salt-induced hypertension and cardiovascular injury more than valsartan alone","volume":"28","author":"Kusaka","year":"2015","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ijcard.2024.132203_bb0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ehjcvp\/pvaa125","article-title":"Different left ventricular remodelling patterns and clinical outcomes between non-ischaemic and ischaemic aetiologies in heart failure patients receiving sacubitril\/valsartan treatment","volume":"8","author":"Lee","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"key":"10.1016\/j.ijcard.2024.132203_bb0080","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/jama.2019.12821","article-title":"Association of change in N-terminal pro-B-type natriuretic peptide following initiation of Sacubitril-valsartan treatment with cardiac structure and function in patients with heart failure with reduced ejection fraction","volume":"322","author":"Januzzi","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2024.132203_bb0085","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1161\/01.CIR.0000142858.44680.27","article-title":"Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice","volume":"110","author":"Garnier","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2024.132203_bb0090","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jchf.2020.06.020","article-title":"Sacubitril\/valsartan: Neprilysin inhibition 5 years after PARADIGM-HF","volume":"8","author":"Docherty","year":"2020","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0095","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005565","article-title":"Sacubitril\/valsartan decreases cardiac fibrosis in left ventricle pressure overload by restoring PKG signaling in cardiac fibroblasts","volume":"12","author":"Burke","year":"2019","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2024.132203_bb0100","first-page":"H333","article-title":"Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs","volume":"267","author":"Ihara","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2024.132203_bb0105","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jacc.2010.05.011","article-title":"Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach","volume":"56","author":"Kramer","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0110","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart--an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2024.132203_bb0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/cvr\/cvn301","article-title":"Energy metabolism in heart failure and remodelling","volume":"81","author":"Ingwall","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2024.132203_bb0120","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","article-title":"Expert consensus document: mitochondrial function as a therapeutic target in heart failure","volume":"14","author":"Brown","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.624216","article-title":"Mitochondrial function and dysfunction in dilated cardiomyopathy","volume":"8","author":"Ramaccini","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00395-023-01019-9","article-title":"Targeting mitochondrial shape: at the heart of cardioprotection","volume":"118","author":"Hernandez-Resendiz","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2024.132203_bb0135","doi-asserted-by":"crossref","first-page":"16542","DOI":"10.1038\/s41598-021-95988-3","article-title":"Cardioprotective effects of early intervention with sacubitril\/valsartan on pressure overloaded rat hearts","volume":"11","author":"Li","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2024.132203_bb0140","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jacbts.2020.07.006","article-title":"Differential effects of Sacubitril\/valsartan on diastolic function in mice with obesity-related metabolic heart disease","volume":"5","author":"Croteau","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.ijcard.2024.132203_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-7831-1_3","article-title":"High-resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria","volume":"1782","author":"Doerrier","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132203_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-021-00868-6","article-title":"Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes","volume":"116","author":"Lieder","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"20","key":"10.1016\/j.ijcard.2024.132203_bb0155","doi-asserted-by":"crossref","first-page":"15144","DOI":"10.3390\/ijms242015144","article-title":"Mitochondrial sAC-cAMP-PKA Axis modulates the \u0394\u03a8m-dependent control coefficients of the respiratory chain complexes: evidence of respirasome plasticity","volume":"24","author":"Scrima","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132203_bb0160","doi-asserted-by":"crossref","first-page":"H125","DOI":"10.1152\/ajpheart.00172.2023","article-title":"Mitochondrial respiration analysis in permeabilized porcine left ventricular and human right atrial specimens with ischemia-reperfusion","volume":"325","author":"Eickelmann","year":"2023","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324008258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324008258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:45:10Z","timestamp":1718419510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527324008258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":32,"alternative-id":["S0167527324008258"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132203","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"132203"}}