{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:32:09Z","timestamp":1789623129158,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ijcard.2024.132458","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T18:21:21Z","timestamp":1724350881000},"page":"132458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Evidence of an effect of statins on lesions originating from dental infection. A retrospective clinical investigation"],"prefix":"10.1016","volume":"415","author":[{"given":"Francesca","family":"Ideo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mercuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Niazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mannocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Cotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0005","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/idj.12294","article-title":"A new definition for oral health developed by the FDI world dental federation opens the door to a universal definition of oral health","volume":"66","author":"Glick","year":"2016","journal-title":"Int. Dent. J."},{"issue":"9","key":"10.1016\/j.ijcard.2024.132458_bb0010","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/dj11090222","article-title":"Diet, nutrition, and Oral health in older adults: a review of the literature","volume":"11","author":"Chan","year":"2023","journal-title":"Dent J (Basel)."},{"issue":"2","key":"10.1016\/j.ijcard.2024.132458_bb0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.joen.2013.10.036","article-title":"Overlapping protective and destructive regulatory pathways in apical periodontitis","volume":"40","author":"M\u00e1rton","year":"2014","journal-title":"J. Endod."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/iej.13987","article-title":"EndoReCo. Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: a report from the PAROKRANK study","volume":"57","author":"Sebring","year":"2024","journal-title":"Int. Endod. J."},{"issue":"7","key":"10.1016\/j.ijcard.2024.132458_bb0030","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/medicina58070931","article-title":"Association between endodontic infection, its treatment and systemic health: a narrative review","volume":"58","author":"Niazi","year":"2022","journal-title":"Medicina (Kaunas)"},{"issue":"10","key":"10.1016\/j.ijcard.2024.132458_bb0035","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/iej.12507","article-title":"Endodontic medicine: connections between apical periodontitis and systemic diseases","volume":"48","author":"Segura-Egea","year":"2015","journal-title":"Int. Endod. J."},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0040","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2015.01.037","article-title":"Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women","volume":"41","author":"Cotti","year":"2015","journal-title":"J. Endod."},{"issue":"2","key":"10.1016\/j.ijcard.2024.132458_bb0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2710.2009.01085.x","article-title":"A systematic review and meta-analysis on the therapeutic equivalence of statins","volume":"35","author":"Weng","year":"2010","journal-title":"J. Clin. Pharm. Ther."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/cr.2008.61","article-title":"Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase","volume":"18","author":"DeBose-Boyd","year":"2008","journal-title":"Cell Res."},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0055","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/138161209787315684","article-title":"Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy","volume":"15","author":"Zhou","year":"2009","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.ijcard.2024.132458_bb0065","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/138161212799504803","article-title":"Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials","volume":"18","author":"Antonopoulos","year":"2012","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0070","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1186\/s12903-023-03472-3","article-title":"The role of systemic statins in the inception and healing of apical periodontitis: a systematic review","volume":"23","author":"Ideo","year":"2023","journal-title":"BMC Oral. Health"},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0075","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.joen.2009.02.004","article-title":"Simvastatin as a novel strategy to alleviate periapical lesions","volume":"35","author":"Lin","year":"2009","journal-title":"J. Endod."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0080","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.joen.2012.02.023","article-title":"Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts","volume":"38","author":"Lai","year":"2012","journal-title":"J. Endod."},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0085","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.joen.2012.12.014","article-title":"Simvastatin suppresses osteoblastic expression of Cyr61 and progression of apical periodontitis through enhancement of the transcription factor Forkhead\/winged helix box protein O3a","volume":"39","author":"Lin","year":"2013","journal-title":"J. Endod."},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0090","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/iej.13055","article-title":"Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis","volume":"52","author":"Yang","year":"2019","journal-title":"Int. Endod. J."},{"issue":"11","key":"10.1016\/j.ijcard.2024.132458_bb0095","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/iej.12101","article-title":"Effect of simvastatin on kinetics of osteoprotegrin\/receptor activator nuclear kappa B Ligand mRNA expression in periapical lesions","volume":"46","author":"Shadmehr","year":"2013","journal-title":"Int. Endod. J."},{"issue":"9","key":"10.1016\/j.ijcard.2024.132458_bb0100","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.joen.2018.06.013","article-title":"Healing of apical periodontitis after nonsurgical root canal treatment: the role of statin intake","volume":"44","author":"Alghofaily","year":"2018","journal-title":"J. Endod."},{"issue":"Suppl. 20","key":"10.1016\/j.ijcard.2024.132458_bb0110","first-page":"S162","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"issue":"Suppl. 4","key":"10.1016\/j.ijcard.2024.132458_bb0115","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/iej.13828","article-title":"Present status and future directions: imaging techniques for the detection of periapical lesions","volume":"55","author":"Cotti","year":"2022","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.ijcard.2024.132458_bb0120","series-title":"Oral Health Surveys: Basic Methods","author":"World Health Organization","year":"1997"},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0125","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-9657.1986.tb00119.x","article-title":"The periapical index: a scoring system for radiographic assessment of apical periodontitis","volume":"2","author":"Orstavik","year":"1986","journal-title":"Endod. Dent. Traumatol."},{"issue":"10","key":"10.1016\/j.ijcard.2024.132458_bb0130","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.joen.2009.06.021","article-title":"A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures","volume":"35","author":"Bose","year":"2009","journal-title":"J. Endod."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0135","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/JTO.0b013e318200f983","article-title":"Measures of interrater agreement","volume":"6","author":"Mandrekar","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"7","key":"10.1016\/j.ijcard.2024.132458_bb0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2591.2011.01872.x","article-title":"A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health","volume":"44","author":"Ng","year":"2011","journal-title":"Int. Endod. J."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0145","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.joen.2022.02.008","article-title":"Prevalence of apical periodontitis in patients with autoimmune diseases under Immunomodulators: a retrospective cohort study","volume":"48","author":"Ideo","year":"2022","journal-title":"J. Endod."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0150","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.joen.2024.02.026","article-title":"Prevalence of apical periodontitis in patients with autoimmune liver diseases on immune suppressants and immune modulators: a cross-sectional study","volume":"50","author":"Ideo","year":"2024","journal-title":"J. Endod."},{"issue":"5","key":"10.1016\/j.ijcard.2024.132458_bb0155","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s00784-020-03590-0","article-title":"A 12-month follow-up of primary and secondary root canal treatment in teeth obturated with a hydraulic sealer","volume":"25","author":"Bardini","year":"2021","journal-title":"Clin. Oral Investig."},{"issue":"12","key":"10.1016\/j.ijcard.2024.132458_bb0160","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.joen.2018.09.004","article-title":"Healing of apical periodontitis in patients with inflammatory bowel diseases and under anti-tumor necrosis factor alpha therapy","volume":"44","author":"Cotti","year":"2018","journal-title":"J. Endod."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0165","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/ger.12137","article-title":"Prevalence of root canal treatment and periapical radiolucency in elders: a systematic review","volume":"33","author":"Hamedy","year":"2016","journal-title":"Gerodontology"},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0170","first-page":"14","article-title":"Aging as a risk factor on the Immunoexpression of pro-inflammatory IL-1\u03b2, IL-6 and TNF-\u03b1 cytokines in chronic apical periodontitis lesions","volume":"11","author":"Teixeira","year":"2021","journal-title":"Biology (Basel)."},{"issue":"3","key":"10.1016\/j.ijcard.2024.132458_bb0175","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00016357.2018.1521005","article-title":"Inflammatory profile of chronic apical periodontitis: a literature review","volume":"77","author":"Braz-Silva","year":"2019","journal-title":"Acta Odontol. Scand."},{"issue":"11","key":"10.1016\/j.ijcard.2024.132458_bb0180","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.4103\/njcp.njcp_627_20","article-title":"Prevalence of apical periodontitis between root canal-treated and non-treated teeth and between genders: a cross-sectional CBCT study","volume":"24","author":"Mashyakhy","year":"2021","journal-title":"Niger. J. Clin. Pract."},{"key":"10.1016\/j.ijcard.2024.132458_bb0185","series-title":"Pathways of the Pulp 8th","author":"Cohen","year":"2001"},{"issue":"13","key":"10.1016\/j.ijcard.2024.132458_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0757.1997.tb00098.x","article-title":"Apical periodontitis: a dynamic encounter between root canal infection and host response","volume":"2000","author":"Nair","year":"1997","journal-title":"Periodontol"},{"key":"10.1016\/j.ijcard.2024.132458_bb0195","series-title":"StatPearls [Internet]","article-title":"Dental Abscess. 2023 Feb 20","author":"Sanders","year":"2024"},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/iej.12581","article-title":"Prediction of periapical status and tooth extraction","volume":"50","author":"Kirkevang","year":"2017","journal-title":"Int. Endod. J."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0205","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.adaj.2021.01.005","article-title":"The association of apical periodontitis and type 2 diabetes mellitus: a large hospital network cross-sectional case-controlled study","volume":"152","author":"Yip","year":"2021","journal-title":"J. Am. Dent. Assoc."},{"issue":"2","key":"10.1016\/j.ijcard.2024.132458_bb0210","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis--an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.ijcard.2024.132458_bb0215","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.joen.2016.03.011","article-title":"Association of Radiographically Diagnosed Apical Periodontitis and Cardiovascular Disease: a hospital records-based study","volume":"42","author":"An","year":"2016","journal-title":"J. Endod."},{"issue":"7","key":"10.1016\/j.ijcard.2024.132458_bb0220","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00784-013-1156-3","article-title":"The association of chronic apical periodontitis and endodontic therapy with atherosclerosis","volume":"18","author":"Petersen","year":"2014","journal-title":"Clin. Oral Investig."},{"issue":"2","key":"10.1016\/j.ijcard.2024.132458_bb0225","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.joen.2013.10.026","article-title":"Association between chronic apical periodontitis and coronary artery disease","volume":"40","author":"Costa","year":"2014","journal-title":"J. Endod."},{"issue":"12","key":"10.1016\/j.ijcard.2024.132458_bb0230","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/0022034516660509","article-title":"Association of Endodontic Lesions with coronary artery disease","volume":"95","author":"Liljestrand","year":"2016","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.ijcard.2024.132458_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijms.6663","article-title":"Influence of endodontic treatment on systemic oxidative stress","volume":"11","author":"Inchingolo","year":"2013","journal-title":"Int. J. Med. Sci."},{"issue":"12","key":"10.1016\/j.ijcard.2024.132458_bb0240","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.joen.2022.10.004","article-title":"Association of Chronic Systemic Medications with the incidence, prevalence, or healing of endodontic disease: a systematic review","volume":"48","author":"Alghofaily","year":"2022","journal-title":"J. Endod."},{"issue":"12","key":"10.1016\/j.ijcard.2024.132458_bb0245","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.joen.2013.08.008","article-title":"Incidence of cholesterol in periapical biopsies among adolescent and elderly patients","volume":"39","author":"Slutzky-Goldberg","year":"2013","journal-title":"J. Endod."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324010805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324010805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:17:45Z","timestamp":1726273065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527324010805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":47,"alternative-id":["S0167527324010805"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132458","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence of an effect of statins on lesions originating from dental infection. A retrospective clinical investigation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"132458"}}