{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:29:36Z","timestamp":1790116176624,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ijcard.2024.132875","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T22:32:54Z","timestamp":1733437974000},"page":"132875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Left atrial appendage closure in patients with failure of anticoagulation therapy: A multicenter comparative study on the hybrid strategy using DOACs and VKAs"],"prefix":"10.1016","volume":"421","author":[{"given":"Alberto","family":"Preda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Falasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Melillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Margonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Antonio","family":"Posteraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Guarracini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo della","family":"Bella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eustachio","family":"Agricola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Gaspardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2024.132875_bb0005","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0140-6736(95)92339-X","article-title":"Does atrial fibrillation confer a hypercoagulable state?","volume":"346","author":"Lip","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2024.132875_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCULATIONAHA.121.056355","article-title":"Direct Oral anticoagulants versus warfarin in patients with atrial fibrillation: patient-level network Meta-analyses of randomized clinical trials with interaction testing by age and sex","volume":"145","author":"Carnicelli","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2024.132875_bb0015","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/jama.2017.1371","article-title":"Association of preceding antithrombotic treatment with acute ischemic stroke severity and in-hospital outcomes among patients with atrial fibrillation","volume":"317","author":"Xian","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2024.132875_bb0020","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2024.132875_bb0025","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2024.132875_bb0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.25700","article-title":"Ischemic stroke despite Oral anticoagulant therapy in patients with atrial fibrillation","volume":"87","author":"Seiffge","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ijcard.2024.132875_bb0035","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.echo.2014.08.016","article-title":"Prognostic significance of left atrial appendage \u201csludge\u201d in patients with atrial fibrillation: a new transesophageal echocardiographic thromboembolic risk factor","volume":"27","author":"Lowe","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcard.2024.132875_bb0040","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2024.132875_bb0045","doi-asserted-by":"crossref","first-page":"e1038","DOI":"10.4244\/EIJ-D-22-00627","article-title":"Left atrial appendage occlusion","volume":"18","author":"Holmes","year":"2023","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ijcard.2024.132875_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12113859","article-title":"Left atrial appendage occlusion in patients with failure of antithrombotic therapy: good vibes from early studies","volume":"12","author":"Preda","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijcard.2024.132875_bb0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.recesp.2019.02.018","article-title":"Left atrial appendage occlusion for stroke despite oral anticoagulation (resistant stroke). Results from the Amplatzer cardiac plug registry","volume":"73","author":"Cruz-Gonz\u00e1lez","year":"2020","journal-title":"Rev. Esp Cardiol. (Engl. Ed.)"},{"key":"10.1016\/j.ijcard.2024.132875_bb0060","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030380","article-title":"Efficacy and safety of direct Oral anticoagulants for stroke prevention in older patients with atrial fibrillation: a network Meta-analysis of randomized controlled trials","volume":"12","author":"Lin","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcard.2024.132875_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/eurheartj\/ehq406","article-title":"Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the valve academic research consortium","volume":"32","author":"Leon","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2024.132875_bb0070","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.ijcard.2024.132875_bb0075","doi-asserted-by":"crossref","DOI":"10.4244\/EIJY19M08_01","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion \u2013 an update","volume":"15","author":"Glikson","year":"2020","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ijcard.2024.132875_bb0080","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/eurheartj\/ehy136","article-title":"The 2018 European heart rhythm association practical guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation","volume":"39","author":"Steffel","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2024.132875_bb0085","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2024.132875_bb0090","author":"Van Gelder","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2024.132875_bb0095","article-title":"Antiplatelet and anticoagulation for patients with prosthetic heart valves","author":"Massel","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijcard.2024.132875_bb0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/17434440.2023.2208748","article-title":"Appropriate use criteria of left atrial appendage closure devices: latest evidences","volume":"20","author":"Guarracini","year":"2023","journal-title":"Expert Rev. Med. Devices"},{"key":"10.1016\/j.ijcard.2024.132875_bb0105","first-page":"212","article-title":"Left atrial appendage occlusion as adjunctive therapy to anticoagulation for stroke recurrence","volume":"31","author":"Freixa","year":"2019","journal-title":"J. Invasive Cardiol."},{"key":"10.1016\/j.ijcard.2024.132875_bb0110","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/17843286.2020.1821494","article-title":"Left atrial appendage occlusion in recurrent ischaemic stroke, a multicentre experience","volume":"77","author":"Galloo","year":"2022","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.ijcard.2024.132875_bb0115","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/joa3.12838","article-title":"Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: is two better than one? Real-world experience from a tertiary care hospital","volume":"39","author":"Margonato","year":"2023","journal-title":"J. Arrhythm."},{"key":"10.1016\/j.ijcard.2024.132875_bb0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.23736\/S0031-0808.21.04446-3","article-title":"Left atrial appendage closure: a new strategy for cardioembolic events despite oral anticoagulation","volume":"65","author":"Falasconi","year":"2023","journal-title":"Panminerva Med."},{"key":"10.1016\/j.ijcard.2024.132875_bb0125","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jacep.2019.11.017","article-title":"Feasibility of left atrial appendage occlusion in left atrial appendage thrombus: a systematic review","volume":"6","author":"Sharma","year":"2020","journal-title":"JACC Clin. Electrophysiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324014979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527324014979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T11:17:08Z","timestamp":1738408628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527324014979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":25,"alternative-id":["S0167527324014979"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132875","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left atrial appendage closure in patients with failure of anticoagulation therapy: A multicenter comparative study on the hybrid strategy using DOACs and VKAs","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2024.132875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"132875"}}