{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:53:24Z","timestamp":1793303604047,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"The Swedish Heart Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021728","name":"Bundy Academy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005753","name":"Royal Physiographic Society of Lund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ijcard.2026.134699","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:35:40Z","timestamp":1784936140000},"page":"134699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Activation of the complement lectin pathway is associated with long-term cardiac dysfunction and incident heart failure in acute coronary syndrome patients"],"prefix":"10.1016","volume":"462","author":[{"given":"Baojun","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan Gheorghita","family":"Mares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil-Marian","family":"Arbanasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Yndigegn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Engelbertsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Bj\u00f6rkbacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Schiopu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2026.134699_bb0005","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/eurheartj\/ehu505","article-title":"Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective","volume":"36","author":"Jernberg","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2026.134699_bb0010","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/eurheartj\/ehi292","article-title":"Prognostic significance of blood markers of inflammation in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty and effects of pexelizumab, a C5 inhibitor: a substudy of the COMMA trial","volume":"26","author":"Th\u00e9roux","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2026.134699_bb0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41577-023-00926-1","article-title":"A guide to complement biology, pathology and therapeutic opportunity","volume":"24","author":"Mastellos","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0020","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/616817","article-title":"Mannan-binding lectin in cardiovascular disease","volume":"2014","author":"P\u0105gowska-Klimek","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijcard.2026.134699_bb0030","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0002-9440(10)65026-2","article-title":"Complement activation after oxidative stress: role of the lectin complement pathway","volume":"156","author":"Collard","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0035","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cvr\/cvs018","article-title":"The innate immune response in reperfused myocardium","volume":"94","author":"Timmers","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2026.134699_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060976","article-title":"Association of ficolin-3 with severity and outcome of chronic heart failure","volume":"8","author":"Proh\u00e1szka","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2026.134699_bb0045","doi-asserted-by":"crossref","first-page":"541","DOI":"10.4049\/jimmunol.175.1.541","article-title":"Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury","volume":"175","author":"Walsh","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0050","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/hc3601.095578","article-title":"Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury","volume":"104","author":"Jordan","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2026.134699_bb0055","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/07853890903110994","article-title":"Mannose-binding lectin as a risk factor for acute coronary syndromes","volume":"41","author":"Pesonen","year":"2009","journal-title":"Ann. Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/srep43045","article-title":"Pentraxin 3, ficolin-2 and lectin pathway associated serine protease MASP-3 as early predictors of myocardial infarction - the HUNT2 study","volume":"7","author":"Vengen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2026.134699_bb0065","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2026.134699_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2026.134699_bb0075","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2022.10.146","article-title":"IncidenCe and predictOrs of heaRt fAiLure after acute coronarY syndrome: the CORALYS registry","volume":"370","author":"De Filippo","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.gene.6364283","article-title":"Mannose-binding lectin and its genetic variants","volume":"7","author":"Garred","year":"2006","journal-title":"Genes Immun."},{"key":"10.1016\/j.ijcard.2026.134699_bb0090","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-3083.2007.01991.x","article-title":"Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise","volume":"66","author":"Ytting","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2165\/00063030-200115090-00004","article-title":"Role of the complement system in ischaemic heart disease: potential for pharmacological intervention","volume":"15","author":"Shernan","year":"2001","journal-title":"BioDrugs"},{"key":"10.1016\/j.ijcard.2026.134699_bb0100","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0002-9440(10)63830-8","article-title":"Complement in ischemia reperfusion injury","volume":"162","author":"Riedemann","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2026.134699_bb0110","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.133.4.885","article-title":"The phlogistic role of C3 leukotactic fragments in myocardial infarcts of rats","volume":"133","author":"Hill","year":"1971","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.57.1.119","article-title":"Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle. A possible initiator of an extra myocardial mechanism of ischemic injury","volume":"57","author":"Rossen","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2026.134699_bb0120","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4049\/jimmunol.137.6.1945","article-title":"Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium","volume":"137","author":"Sch\u00e4fer","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0125","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1161\/01.CIR.97.22.2259","article-title":"Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy","volume":"97","author":"Vakeva","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2026.134699_bb0130","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1111\/bph.15307","article-title":"Sweet turning bitter: carbohydrate sensing of complement in host defence and disease","volume":"178","author":"Hevey","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0135","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s00125-008-1044-6","article-title":"Mannose-binding lectin plays a critical role in myocardial ischaemia and reperfusion injury in a mouse model of diabetes","volume":"51","author":"Busche","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2026.134699_bb0140","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.imbio.2015.09.010","article-title":"Mannose-binding lectin (MBL) insufficiency protects against the development of systemic inflammatory response after pediatric cardiac surgery","volume":"221","author":"P\u0105gowska-Klimek","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.ijcard.2026.134699_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ajpath.2014.10.015","article-title":"Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model","volume":"185","author":"Pavlov","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0150","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2017-000652","article-title":"Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction","volume":"5","author":"Clark","year":"2018","journal-title":"Open Heart"},{"key":"10.1016\/j.ijcard.2026.134699_bb0155","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/ajh.70044","article-title":"Narsoplimab results in excellent survival in adults and children with hematopoietic cell transplant associated thrombotic Microangiopathy (TA-TMA)","volume":"100","author":"Schoettler","year":"2025","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0160","first-page":"13","article-title":"Level of complement activity predicts cardiac dysfunction after acute myocardial infarction treated with primary percutaneous coronary intervention","volume":"21","author":"Haahr-Pedersen","year":"2009","journal-title":"J. Invasive Cardiol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0165","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.molimm.2013.01.008","article-title":"Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study","volume":"54","author":"Schoos","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/cei.13315","article-title":"Circulating lectin pathway proteins do not predict short-term cardiac outcomes after myocardial infarction","volume":"198","author":"Holt","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijcard.2026.134699_bb0175","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/eurheartj\/ehp597","article-title":"Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"31","author":"Trendelenburg","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2026.134699_bb0180","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025955","article-title":"ANGPTL3 and cardiovascular outcomes in patients with acute coronary syndrome and obstructive sleep apnea","volume":"11","author":"Lv","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcard.2026.134699_bb0185","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0190","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/CIRCULATIONAHA.110.936393","article-title":"Lipoprotein-associated and secreted phospholipases a\u2082 in cardiovascular disease: roles as biological effectors and biomarkers","volume":"122","author":"Mallat","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2026.134699_bb0195","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1096\/fj.13-247650","article-title":"Crosstalk between TGF-\u03b21 and complement activation augments epithelial injury in pulmonary fibrosis","volume":"28","author":"Gu","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.ijcard.2026.134699_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1643674","article-title":"Identification of the potential molecular mechanism of TGFBI gene in persistent atrial fibrillation","volume":"2022","author":"Guan","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.913156","article-title":"Fibulin-3 deficiency protects against myocardial injury following Ischaemia\/ reperfusion in in vitro cardiac spheroids","volume":"9","author":"Sharma","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2026.134699_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008433","article-title":"Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke","volume":"5","author":"Cervera","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2026.134699_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021338","article-title":"Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients","volume":"6","author":"Osthoff","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2026.134699_bb0220","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ehf2.12266","article-title":"Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock","volume":"5","author":"Orrem","year":"2018","journal-title":"ESC Heart Fail."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527326005498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527326005498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:28:59Z","timestamp":1787675339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527326005498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0167527326005498"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2026.134699","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of the complement lectin pathway is associated with long-term cardiac dysfunction and incident heart failure in acute coronary syndrome patients","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2026.134699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"134699"}}