{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:00Z","timestamp":1787678340102,"version":"build-2784847793"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ijcard.2026.134718","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:34:19Z","timestamp":1786322059000},"page":"134718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of variant reclassification on genetic testing yield and clinical outlook in patients with hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"462","author":[{"given":"Annamaria","family":"Del Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Setti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Colio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bonacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Biagioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Giovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Insinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Gozzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Zampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pieroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Girolami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2026.134718_bb0005","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the Sarcomeric human cardiomyopathy registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2026.134718_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1202381","article-title":"Application of next generation sequencing in cardiology: current and future precision medicine implications","volume":"10","author":"Papadopoulou","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jgc4.1075","article-title":"Patients\u2019 perspectives of variants of uncertain significance and strategies for uncertainty management","volume":"28","author":"Makhnoon","year":"2019","journal-title":"J. Genet. Couns."},{"key":"10.1016\/j.ijcard.2026.134718_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2023.100801","article-title":"Practical considerations for reinterpretation of individual genetic variants","volume":"25","author":"Appelbaum","year":"2023","journal-title":"Genet. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0025","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/gim.2013.138","article-title":"Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment","volume":"16","author":"Das","year":"2014","journal-title":"Genet. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0030","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/eurheartj\/ehab895","article-title":"Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics","volume":"43","author":"Arbustini","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2026.134718_bb0035","doi-asserted-by":"crossref","unstructured":"Arbelo E, Protonotarios A, Gimeno JR, Arbustini E, Barriales-Villa R, Basso C, Et al; ESC scientific document group. 2023 ESC guidelines for the management of cardiomyopathies. Eur. Heart J. 2023;44:3503\u20133626.","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"10.1016\/j.ijcard.2026.134718_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12072489","article-title":"Genetic testing and counselling in hypertrophic cardiomyopathy: frequently asked questions","volume":"12","author":"Girolami","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0045","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41436-018-0039-z","article-title":"ACMG professional practice and guidelines committee. Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)","volume":"20","author":"Hershberger","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0050","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jacc.2024.12.010","article-title":"ClinGen hereditary cardiovascular disease gene curation expert panel: reappraisal of genes associated with hypertrophic cardiomyopathy","volume":"85","author":"Hespe","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2026.134718_bb0055","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41431-023-01421-w","article-title":"EMQN: recommendations for genetic testing in inherited cardiomyopathies and arrhythmias","volume":"31","author":"Hayesmoore","year":"2023","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ijcard.2026.134718_bb0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"ACMG laboratory quality assurance committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0065","series-title":"ACGS Best Practice Guidelines for Variant Classification in Rare Disease","author":"Durkie","year":"2024"},{"key":"10.1016\/j.ijcard.2026.134718_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102732","article-title":"Reanalysis and reclassification of rare genetic variants associated with inherited arrhythmogenic syndromes","volume":"54","author":"Campuzano","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ijcard.2026.134718_bb0075","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/eurjpc\/zwad325","article-title":"Retrospective variant reclassification and resequencing in hypertrophic cardiomyopathy: a reference unit Centre experience","volume":"31","author":"Cuesta-Llavona","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.ijcard.2026.134718_bb0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/jmg-2024-110208","article-title":"Reassessment and reclassification of variants of unknown significance in patients with cardiomyopathy in a specialist department","volume":"62","author":"Horgan","year":"2025","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ijcard.2026.134718_bb0085","article-title":"Impact of GLA variant classification on the estimated prevalence of Fabry disease: a systematic review and meta-analysis of screening studies","volume":"16","author":"Monda","year":"2023","journal-title":"Circ. Genom. Precis. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0090","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/eurheartj\/ehae747","article-title":"Integration of genetic testing into diagnostic pathways for cardiomyopathies: a clinical consensus statement by the ESC Council on cardiovascular genomics","volume":"46","author":"Elliott","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2026.134718_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2025.101400","article-title":"Distinct rates of VUS reclassification are observed when subclassifying VUS by evidence level","volume":"27","author":"Bennett","year":"2025","journal-title":"Genet. Med."},{"key":"10.1016\/j.ijcard.2026.134718_bb0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2023.11.005","article-title":"Will variants of uncertain significance still exist in 2030?","volume":"111","author":"Fowler","year":"2024","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ijcard.2026.134718_bb0105","first-page":"170","article-title":"Reinterpretation, reclassification, and its downstream effects: challenges for clinical laboratory geneticists","volume":"12","author":"El Mecky","year":"2019","journal-title":"BMC Med. Genet."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527326005681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527326005681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:29:37Z","timestamp":1787675377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527326005681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":21,"alternative-id":["S0167527326005681"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2026.134718","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of variant reclassification on genetic testing yield and clinical outlook in patients with hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2026.134718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"134718"}}