{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:45:01Z","timestamp":1763005501769,"version":"3.45.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Congenital Heart Disease"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijcchd.2022.100371","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T02:16:27Z","timestamp":1649643387000},"page":"100371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Clinical complications of liver disease in adults after the Fontan operation"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-7202","authenticated-orcid":false,"given":"Bhavesh","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Serper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Ruckdeschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L.","family":"Partington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuli","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-6884","authenticated-orcid":false,"given":"Maarouf A.","family":"Hoteit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11 Suppl 1","key":"10.1016\/j.ijcchd.2022.100371_bib1","first-page":"S32","article-title":"Redefining expectations of long-term survival after the Fontan procedure: twenty-five years of follow-up from the entire population of Australia and New Zealand","volume":"130","author":"d'Udekem","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.ijcchd.2022.100371_bib2","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.amjcard.2017.03.004","article-title":"Effect of Fontan-associated morbidities on survival with intact Fontan circulation","volume":"119","author":"Allen","year":"2017","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100371_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jtcvs.2017.01.056","article-title":"Long-term survival after the Fontan operation: twenty years of experience at a single center","volume":"154","author":"Downing","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"7","key":"10.1016\/j.ijcchd.2022.100371_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00246-012-0315-7","article-title":"The precarious state of the liver after a Fontan operation: summary of a multidisciplinary symposium","volume":"33","author":"Rychik","year":"2012","journal-title":"Pediatr Cardiol"},{"issue":"5","key":"10.1016\/j.ijcchd.2022.100371_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004809","article-title":"Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study","volume":"6","author":"Goldberg","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.ijcchd.2022.100371_bib6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/hrt.2006.094516","article-title":"Hepatic changes in the failing Fontan circulation","volume":"93","author":"Kiesewetter","year":"2007","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100371_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.athoracsur.2008.03.077","article-title":"Liver and cardiac function in the long term after Fontan operation","volume":"86","author":"Camposilvan","year":"2008","journal-title":"Ann Thorac Surg"},{"issue":"21","key":"10.1016\/j.ijcchd.2022.100371_bib8","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/hrt.2010.201772","article-title":"Late hepatic complications after Fontan operation; non-invasive markers of hepatic fibrosis and risk factors","volume":"96","author":"Baek","year":"2010","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100371_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jtcvs.2012.09.005","article-title":"Identifying predictors of hepatic disease in patients after the Fontan operation: a postmortem analysis","volume":"146","author":"Johnson","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100371_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/CIRCULATIONAHA.120.045597","article-title":"Fontan-associated liver disease: screening, management, and transplant considerations","volume":"142","author":"Emamaullee","year":"2020","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100371_bib11","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jtcvs.2004.10.005","article-title":"Progression of liver pathology in patients undergoing the Fontan procedure: chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma","volume":"129","author":"Ghaferi","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"18","key":"10.1016\/j.ijcchd.2022.100371_bib12","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1056\/NEJMc1214222","article-title":"Hepatocellular carcinoma after the Fontan procedure","volume":"368","author":"Asrani","year":"2013","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.ijcchd.2022.100371_bib13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/MEG.0b013e32832e2bec","article-title":"Hepatocellular carcinoma in two patients with cardiac cirrhosis","volume":"22","author":"Saliba","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijcchd.2022.100371_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijcard.2015.12.033","article-title":"Three cases of hepatocellular carcinoma in Fontan patients: review of the literature and suggestions for hepatic screening","volume":"206","author":"Josephus Jitta","year":"2016","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1017\/S1047951116001360","article-title":"Hepatocellular carcinoma in the adult Fontan patient","volume":"27","author":"Conroy","year":"2017","journal-title":"Cardiol Young"},{"issue":"41","key":"10.1016\/j.ijcchd.2022.100371_bib16","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004823","article-title":"Hepatocellular carcinoma after the Fontan procedure in a 16-year-old girl: a case report","volume":"95","author":"Oh","year":"2016","journal-title":"Medicine (Baltim)"},{"issue":"7","key":"10.1016\/j.ijcchd.2022.100371_bib17","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/CIRCULATIONAHA.117.032717","article-title":"Hepatocellular carcinoma after Fontan operation: multicenter case series","volume":"138","author":"Egbe","year":"2018","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ijcchd.2022.100371_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/hepr.13500","article-title":"Characteristics of hepatocellular carcinoma arising from Fontan-associated liver disease","volume":"50","author":"Sagawa","year":"2020","journal-title":"Hepatol Res"},{"issue":"4","key":"10.1016\/j.ijcchd.2022.100371_bib19","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1253\/circj.CJ-17-1053","article-title":"Liver cirrhosis and\/or hepatocellular carcinoma occurring late after the Fontan procedure- A nationwide survey in Japan","volume":"82","author":"Kuwabara","year":"2018","journal-title":"Circ J"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100371_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijcard.2011.06.062","article-title":"Structural and functional uncoupling of liver performance in the Fontan circulation","volume":"164","author":"Guha","year":"2013","journal-title":"Int J Cardiol"},{"issue":"8","key":"10.1016\/j.ijcchd.2022.100371_bib21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1001\/jama.2012.186","article-title":"Does this patient with liver disease have cirrhosis?","volume":"307","author":"Udell","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/chd.12446","article-title":"Surveillance for liver complications after the Fontan procedure","volume":"12","author":"Hilscher","year":"2017","journal-title":"Congenit Heart Dis"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100371_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/lt.20906","article-title":"MELD-XI: a rational approach to \"sickest first\" liver transplantation in cirrhotic patients requiring anticoagulant therapy","volume":"13","author":"Heuman","year":"2007","journal-title":"Liver Transplant"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100371_bib25","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcchd.2022.100371_bib26","unstructured":"Liver Reporting & Data System (LI-RADS): American College of Radiology; [Available from: https:\/\/www.acr.org\/Clinical-Resources\/Reporting-and-Data-Systems\/LI-RADS."},{"issue":"5","key":"10.1016\/j.ijcchd.2022.100371_bib27","doi-asserted-by":"crossref","first-page":"512 e1","DOI":"10.1016\/j.amjmed.2011.07.028","article-title":"Systematic review of noncancer presentations with a median survival of 6 months or less","volume":"125","author":"Salpeter","year":"2012","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"Electronic address eee, European Association for the Study of the L. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","year":"2018","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.ijcchd.2022.100371_bib29","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1111\/j.1572-0241.2001.04130.x","article-title":"Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy","volume":"96","author":"Romero-Gomez","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.ijcchd.2022.100371_bib30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jtcvs.2016.10.060","article-title":"Liver health in adults with Fontan circulation: a multicenter cross-sectional study","volume":"153","author":"Wu","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5604\/01.3001.0010.8634","article-title":"Fontan-associated liver disease: a review","volume":"17","author":"Tellez","year":"2018","journal-title":"Ann Hepatol"},{"issue":"3","key":"10.1016\/j.ijcchd.2022.100371_bib32","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.amjcard.2015.11.014","article-title":"Liver disease in patients after the Fontan operation","volume":"117","author":"Pundi","year":"2016","journal-title":"Am J Cardiol"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100371_bib33","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ejcts.2009.02.043","article-title":"Portal-systemic encephalopathy after Fontan-type operation in patient with polysplenia syndrome","volume":"35","author":"Koteda","year":"2009","journal-title":"Eur J Cardio Thorac Surg"},{"issue":"4","key":"10.1016\/j.ijcchd.2022.100371_bib34","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1016\/j.ijcard.2013.06.008","article-title":"Features of portal hypertension are associated with major adverse events in Fontan patients: the VAST study","volume":"168","author":"Elder","year":"2013","journal-title":"Int J Cardiol"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100371_bib35","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.21176","article-title":"The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients","volume":"43","author":"Sangiovanni","year":"2006","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.ijcchd.2022.100371_bib36","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.cgh.2007.02.039","article-title":"Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis","volume":"5","author":"Ioannou","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.ijcchd.2022.100371_bib37","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2020.08.057","article-title":"Hepatocellular carcinoma and the Fontan circulation: clinical presentation and outcomes","volume":"322","author":"Possner","year":"2021","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.ijcchd.2022.100371_bib38","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/jlts.2002.35927","article-title":"The new liver allocation system: moving toward evidence-based transplantation policy","volume":"8","author":"Freeman","year":"2002","journal-title":"Liver Transplant"},{"issue":"7","key":"10.1016\/j.ijcchd.2022.100371_bib39","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s00246-016-1428-1","article-title":"MELD-XI scores correlate with post-Fontan hepatic biopsy fibrosis scores","volume":"37","author":"Evans","year":"2016","journal-title":"Pediatr Cardiol"},{"issue":"8","key":"10.1016\/j.ijcchd.2022.100371_bib40","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s00246-018-1937-1","article-title":"Hepatic changes in the Fontan circulation: identification of liver dysfunction and an attempt to streamline follow-up screening","volume":"39","author":"Ackerman","year":"2018","journal-title":"Pediatr Cardiol"},{"issue":"13","key":"10.1016\/j.ijcchd.2022.100371_bib41","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/eurheartj\/ehy620","article-title":"The clinical spectrum of Fontan-associated liver disease: results from a prospective multimodality screening cohort","volume":"40","author":"Munsterman","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2022.100371_bib42","first-page":"140","article-title":"Abstract 14367: diuretic use is associated with worse transplant-Free survival in adult Fontan patients","volume":"140","author":"Ortega-Legaspi","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ijcchd.2022.100371_bib43","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ejcts\/ezaa310","article-title":"Evaluation of Fontan failure by classifying the severity of Fontan-associated liver disease: a single-centre cross-sectional study","volume":"59","author":"Schleiger","year":"2020","journal-title":"Eur J Cardio Thorac Surg"},{"issue":"5","key":"10.1016\/j.ijcchd.2022.100371_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/chd.12820","article-title":"More than the heart: hepatic, renal, and cardiac dysfunction in adult Fontan patients","volume":"14","author":"Byrne","year":"2019","journal-title":"Congenit Heart Dis"}],"container-title":["International Journal of Cardiology Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668522000544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668522000544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:41:44Z","timestamp":1763005304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666668522000544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":44,"alternative-id":["S2666668522000544"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcchd.2022.100371","relation":{},"ISSN":["2666-6685"],"issn-type":[{"type":"print","value":"2666-6685"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical complications of liver disease in adults after the Fontan operation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Congenital Heart Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcchd.2022.100371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100371"}}