{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:45:03Z","timestamp":1763005503875,"version":"3.45.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Congenital Heart Disease"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijcchd.2022.100385","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:22:39Z","timestamp":1651148559000},"page":"100385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Is there a role for angiotensin II\u2013receptor blockers for ascending aorta dilatation in pediatric patients with normally functioning bicuspid aortic valve?"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-0159","authenticated-orcid":false,"given":"Elisabetta","family":"Mariucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Guidarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylenia","family":"Bartolacelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Tchana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Careddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna Maria Roberta","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Donti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcchd.2022.100385_bib1","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2022.100385_bib2","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve","volume":"370","author":"Verma","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcchd.2022.100385_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0735-1097(92)90479-7","article-title":"Association of aortic dilatation with regurgitant, stenotic and functionally normal bicuspid aortic valves","volume":"19","author":"Hahn","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcchd.2022.100385_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-9149(03)00462-4","article-title":"Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves","volume":"92","author":"Ferencik","year":"2003","journal-title":"Am J Cardiol"},{"issue":"13","key":"10.1016\/j.ijcchd.2022.100385_bib5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/heartjnl-2012-301773","article-title":"Bicuspid aortic valve and associated aortic dilation in the young","volume":"98","author":"Fernandes","year":"2012","journal-title":"Heart"},{"issue":"3","key":"10.1016\/j.ijcchd.2022.100385_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009717","article-title":"Predictors of bicuspid aortic valve-associated aortopathy in childhood: a report from the MIBAVA Consortium","volume":"13","author":"Grattan","year":"2020","journal-title":"Circ Cardiovasc Imag"},{"key":"10.1016\/j.ijcchd.2022.100385_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.amjcard.2020.12.050","article-title":"Effect of losartan or atenolol on children and young adults with bicuspid aortic valve and dilated aorta","volume":"144","author":"Flyer","year":"2021","journal-title":"Am J Cardiol"},{"issue":"10","key":"10.1016\/j.ijcchd.2022.100385_bib8","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/hrt.2005.081539","article-title":"Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors","volume":"92","author":"Warren","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.ijcchd.2022.100385_bib9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.echo.2013.02.018","article-title":"Echocardiographic methods, quality review, and measurement accuracy in a randomized multicenter clinical trial of Marfan syndrome","volume":"26","author":"Tierney","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ijcchd.2022.100385_bib10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.amjcard.2009.11.040","article-title":"Nomograms for aortic root diameters in children using two-dimensional echocardiography","volume":"105","author":"Gautier","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcchd.2022.100385_bib11","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archinte.1916.00080130010002","article-title":"A formula to estimate the approximate surface area if height and weight be known","volume":"17","author":"DuBois","year":"1916","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100385_bib12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCULATIONAHA.108.795401","article-title":"Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications","volume":"119","author":"Tadros","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2022.100385_bib13","doi-asserted-by":"crossref","first-page":"II329","DOI":"10.1161\/01.cir.0000087660.82721.15","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in Marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100385_bib14","first-page":"66","article-title":"Recent clinical drug trials evidence in marfan syndrome and clinical implications","volume":"32","author":"Singh","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ijcchd.2022.100385_bib15","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Atenolol versus losartan in children and young adults with Marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ijcchd.2022.100385_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cjco.2019.03.002","article-title":"Practice variation among Canadian pediatric cardiologists in medical management of dilated ascending aorta in patients with bicuspid aortic valve","volume":"1","author":"Hussain","year":"2019","journal-title":"CJC Open"},{"issue":"6","key":"10.1016\/j.ijcchd.2022.100385_bib17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","article-title":"ESC Scientific Document Group. 2020 ESC Guidelines for the management of adult congenital heart disease","volume":"42","author":"Baumgartner","year":"2021","journal-title":"Eur Heart J"},{"issue":"41","key":"10.1016\/j.ijcchd.2022.100385_bib18","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.ijcchd.2022.100385_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12968-020-00608-0","article-title":"4D flow cardiovascular magnetic resonance for monitoring of aortic valve repair in bicuspid aortic valve disease","volume":"22","author":"Lenz","year":"2020","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["International Journal of Cardiology Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668522000684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668522000684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:41:52Z","timestamp":1763005312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666668522000684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":19,"alternative-id":["S2666668522000684"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcchd.2022.100385","relation":{},"ISSN":["2666-6685"],"issn-type":[{"type":"print","value":"2666-6685"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there a role for angiotensin II\u2013receptor blockers for ascending aorta dilatation in pediatric patients with normally functioning bicuspid aortic valve?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Congenital Heart Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcchd.2022.100385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100385"}}