{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:05:34Z","timestamp":1773371134266,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Congenital Heart Disease"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijcchd.2025.100638","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:35:54Z","timestamp":1762392954000},"page":"100638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinical characteristics and outcomes of cardiovascular surgery and transcatheter procedures in adults with Down syndrome and congenital heart disease"],"prefix":"10.1016","volume":"22","author":[{"given":"Takumi","family":"Osawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-7112","authenticated-orcid":false,"given":"Tomoko","family":"Machino-Ohtsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Kume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshiro","family":"Kanaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Sumita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruriko","family":"Numata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kawamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcchd.2025.100638_bib1","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1056\/NEJMra1706537","article-title":"Down syndrome","volume":"382","author":"Bull","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcchd.2025.100638_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/uog.8977","article-title":"Prenatally detectable congenital heart defects in fetuses with Down syndrome","volume":"38","author":"Mogra","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ijcchd.2025.100638_bib3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ejmg.2015.11.003","article-title":"Associated congenital anomalies among cases with Down syndrome","volume":"58","author":"Stoll","year":"2015","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.ijcchd.2025.100638_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8","article-title":"Population-based study of congenital heart defects in Down syndrome","volume":"80","author":"Freeman","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ijcchd.2025.100638_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036214","volume":"13","author":"Peterson","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ijcchd.2025.100638_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpeds.2017.11.014","article-title":"Improvement of outcomes for children with Down syndrome","volume":"193","author":"Bull","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.ijcchd.2025.100638_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/jir.12026","article-title":"The triple challenges associated with age-related comorbidities in Down syndrome: age-related challenges in Down syndrome","volume":"58","author":"Glasson","year":"2014","journal-title":"J Intellect Disabil Res"},{"key":"10.1016\/j.ijcchd.2025.100638_bib8","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1001\/jama.2020.17024","article-title":"Global Down syndrome foundation medical care guidelines for adults with Down syndrome workgroup, medical care of adults with Down syndrome: a clinical guideline: a clinical guideline","volume":"324","author":"Tsou","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ijcchd.2025.100638_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCULATIONAHA.122.059706","article-title":"For Down Syndrome International (DSi), cardiovascular complications of Down syndrome: scoping review and expert consensus","volume":"147","author":"Dimopoulos","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2025.100638_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jacc.2021.04.096","article-title":"Enhanced assessment of perioperative mortality risk in adults with congenital heart disease","volume":"78","author":"Constantine","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcchd.2025.100638_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1253\/circj.CJ-17-0483","article-title":"Current surgical outcomes of congenital heart surgery for patients with Down syndrome in Japan","volume":"82","author":"Hoashi","year":"2018","journal-title":"Circ J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib12","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1253\/circj.CJ-16-0196","article-title":"On the behalf of JROAD investigators, the current status of cardiovascular medicine in Japan - analysis of a large number of health records from a nationwide claim-based database, JROAD-DPC","volume":"80","author":"Yasuda","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib13","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1253\/circj.CJ-18-0487","article-title":"Number of board-certified cardiologists and acute myocardial infarction-related mortality in Japan - JROAD and JROAD-DPC registry analysis","volume":"82","author":"Kanaoka","year":"2018","journal-title":"Circ J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib14","article-title":"Clinical characteristics and outcomes of cardiac surgery and transcatheter procedures in patients with adult congenital heart disease \u2015 insights from Japanese registry data","author":"Osawa","year":"2025","journal-title":"Circ"},{"key":"10.1016\/j.ijcchd.2025.100638_bib15","doi-asserted-by":"crossref","DOI":"10.1253\/circj.CJ-23-0015","article-title":"Trends in unplanned admissions of patients with adult congenital heart disease based on the Japanese registry of all cardiac and vascular diseases-diagnosis procedure combination study","author":"Kuraoka","year":"2023","journal-title":"Circ J Advpub"},{"key":"10.1016\/j.ijcchd.2025.100638_bib16","series-title":"In-Hospital death and end-of-life status among patients with adult congenital heart disease - a retrospective study using the JROAD-DPC database in Japan","author":"Akiyama","year":"2023"},{"key":"10.1016\/j.ijcchd.2025.100638_bib17","first-page":"e698","article-title":"AHA\/ACC guideline for the management of adults with congenital heart disease: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines","volume":"139","author":"Stout","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2025.100638_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","volume":"42","author":"Baumgartner","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/2150135121991528","article-title":"Updating an empirically based tool for analyzing congenital heart surgery mortality","volume":"12","author":"Jacobs","year":"2021","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1067\/mtc.2002.119064","article-title":"Consensus-based method for risk adjustment for surgery for congenital heart disease","volume":"123","author":"Jenkins","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardio Thorac Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/j.jvca.2012.07.017","article-title":"Pulmonary hypertension in patients undergoing cardiac surgery: pathophysiology, perioperative management, and outcomes","volume":"27","author":"Thunberg","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.ijcchd.2025.100638_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jjcc.2019.06.010","article-title":"Impact of facilities accredited by both adult and pediatric cardiology societies on the outcome of patients with adult congenital heart disease","volume":"75","author":"Mizuno","year":"2020","journal-title":"J Cardiol"},{"key":"10.1016\/j.ijcchd.2025.100638_bib24","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.athoracsur.2015.07.002","article-title":"Estimating mortality risk for adult congenital heart surgery: an analysis of the society of thoracic surgeons congenital heart surgery database","volume":"100","author":"Fuller","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11748-023-01979-8","article-title":"Thoracic and cardiovascular surgeries in Japan during 2020 : annual report by the Japanese association for thoracic surgery: annual report by the Japanese association for thoracic Surgery","volume":"72","author":"Matsumiya","year":"2024","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1747-0803.2009.00349.x","article-title":"Adults with Down syndrome: safety and long-term outcome of cardiac operation","volume":"5","author":"Majdalany","year":"2010","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.ijcchd.2025.100638_bib27","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.athoracsur.2021.04.002","article-title":"Risk factors for perioperative morbidity in adults undergoing cardiac surgery at children's hospitals","volume":"113","author":"Jain","year":"2022","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ijcchd.2025.100638_bib28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1136\/heartjnl-2016-310384","article-title":"Contemporary cardiac surgery for adults with congenital heart disease","volume":"103","author":"Beurtheret","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.ijcchd.2025.100638_bib29","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1161\/CIRCULATIONAHA.113.005817","article-title":"Specialized adult congenital heart disease care: the impact of policy on mortality: the impact of policy on mortality","volume":"129","author":"Mylotte","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2025.100638_bib30","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/eurheartj\/ehz187","article-title":"Frailty and related outcomes in patients undergoing transcatheter valve therapies in a nationwide cohort","volume":"40","author":"Kundi","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jpeds.2018.06.031","article-title":"Clinical characteristics and risk factors for developing pulmonary hypertension in children with Down syndrome","volume":"202","author":"Bush","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.ijcchd.2025.100638_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4250\/jcu.2015.23.2.72","article-title":"Prevalence of congenital heart disease and pulmonary hypertension in down's syndrome: an echocardiographic study","volume":"23","author":"Espinola-Zavaleta","year":"2015","journal-title":"J Cardiovasc Ultrasound"},{"key":"10.1016\/j.ijcchd.2025.100638_bib33","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.hlc.2017.05.133","article-title":"Morbidity after cardiac surgery in patients with adult congenital heart disease in comparison with acquired disease","volume":"27","author":"Karangelis","year":"2018","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.ijcchd.2025.100638_bib34","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"ESC\/ERS Scientific Document Group, 2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2025.100638_bib35","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.athoracsur.2017.12.018","article-title":"Evaluation of the adult congenital heart surgery mortality score at two European centers","volume":"105","author":"H\u00f6rer","year":"2018","journal-title":"Ann Thorac Surg"}],"container-title":["International Journal of Cardiology Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668525000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668525000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:04:50Z","timestamp":1773331490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666668525000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":35,"alternative-id":["S2666668525000746"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcchd.2025.100638","relation":{},"ISSN":["2666-6685"],"issn-type":[{"value":"2666-6685","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and outcomes of cardiovascular surgery and transcatheter procedures in adults with Down syndrome and congenital heart disease","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Congenital Heart Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcchd.2025.100638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100638"}}