{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:06:41Z","timestamp":1789200401184,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Congenital Heart Disease"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ijcchd.2026.100688","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:24:54Z","timestamp":1782750294000},"page":"100688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A bibliometric analysis of medication studies in congenital heart disease"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4376-9564","authenticated-orcid":false,"given":"Hugo","family":"Veldtman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdullah","family":"Nizam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Kandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Schoones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Finn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al-Najashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cleland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Opotowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominica","family":"Zentner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Alsaied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia D.","family":"Egorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-2662","authenticated-orcid":false,"given":"Gruschen","family":"Veldtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcchd.2026.100688_bib1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s12013-015-0551-6","article-title":"Congenital heart disease: causes, diagnosis, symptoms, and treatments","volume":"72","author":"Sun","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.ijcchd.2026.100688_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrcardio.2010.166","article-title":"The changing epidemiology of congenital heart disease","volume":"8","author":"van der Bom","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ijcchd.2026.100688_bib3","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1161\/CIRCRESAHA.116.309302","article-title":"Changing landscape of congenital heart disease","volume":"120","author":"Bouma","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcchd.2026.100688_bib4","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1001\/jama.298.10.1214","article-title":"The importance of randomized controlled trials in pediatric cardiology","volume":"298","author":"Gidding","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ijcchd.2026.100688_bib5","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.jtcvs.2018.02.115","article-title":"The American association for Thoracic surgery consensus guidelines on bicuspid aortic valve\u2013related aortopathy: full online-only version","volume":"156","author":"Borger","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ijcchd.2026.100688_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(02)07283-5","article-title":"An overview of clinical research: the lay of the land","volume":"359","author":"Grimes","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijcchd.2026.100688_bib7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/chd.12764","article-title":"The acute effects of 30 mg vs 60 mg of intravenous Fasudil on patients with congenital heart defects and severe pulmonary arterial hypertension","volume":"14","author":"Ruan","year":"2019","journal-title":"Structural and Congenital Heart Disease"},{"key":"10.1016\/j.ijcchd.2026.100688_bib8","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1093\/eurheartj\/ehaa844","article-title":"Current use and safety of novel oral anticoagulants in adults with congenital heart disease: results of a nationwide analysis including more than 44 000 patients","volume":"41","author":"Freisinger","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2026.100688_bib9","first-page":"e698","article-title":"2018 AHA\/ACC Guideline for the management of adults with congenital heart disease: a report of the American college of Cardiology\/American heart association task force on clinical practice guidelines","volume":"139","author":"Stout","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2026.100688_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","volume":"42","author":"Baumgartner","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcchd.2026.100688_bib11","first-page":"862","article-title":"Canadian Cardiovascular Society 2022 Guidelines for cardiovascular interventions in adults with congenital heart disease \u2217","volume":"38","author":"Marelli","year":"2022","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ijcchd.2026.100688_bib12","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.amjcard.2013.07.027","article-title":"Usefulness of medical therapy for pulmonary hypertension and delayed atrial septal defect closure","volume":"112","author":"Bradley","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcchd.2026.100688_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijcard.2007.04.078","article-title":"Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study","volume":"127","author":"Gatzoulis","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcchd.2026.100688_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/CIRCULATIONAHA.109.883876","article-title":"Improved survival among patients with Eisenmenger syndrome receiving advanced therapy for pulmonary arterial hypertension","volume":"121","author":"Dimopoulos","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2026.100688_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jcin.2008.01.008","article-title":"Randomized clinical Trials and observational Studies: guidelines for assessing respective strengths and limitations","volume":"1","author":"Hannan","year":"2008","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ijcchd.2026.100688_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.arcped.2022.03.004","article-title":"Impact of COVID-19 disease on clinical research in pediatric and congenital cardiology","volume":"29","author":"Pommier","year":"2022","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.ijcchd.2026.100688_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19188","article-title":"Analysis of congenital heart disease research: mapping impact, production and global collaboration","volume":"9","author":"Zila-Velasque","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.ijcchd.2026.100688_bib18","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2020-003650","article-title":"Article processing charges are stalling the progress of African researchers: a call for urgent reforms","volume":"5","author":"Nabyonga-Orem","year":"2020","journal-title":"BMJ Glob Health"},{"key":"10.1016\/j.ijcchd.2026.100688_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2019.1870","article-title":"Disparity of race reporting and representation in clinical trials leading to cancer drug approvals from 2008 to 2018","volume":"5","author":"Loree","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijcchd.2026.100688_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.008685","article-title":"Factors associated with racial and ethnic diversity among heart failure trial participants: a systematic bibliometric review","volume":"15","author":"Wei","year":"2022","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ijcchd.2026.100688_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/circ.148.suppl_1.14112","article-title":"U.S.P.H.S.R. (USPHSR) investigators, abstract 14112: reproductive risk factors and pulmonary arterial hypertension in women","volume":"148","author":"Badlam","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2026.100688_bib22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jacc.2024.02.017","article-title":"Effect of sodium-glucose cotransporter 2 inhibitors in adults with congenital heart disease","volume":"83","author":"L","year":"2024","journal-title":"JACC (J Am Coll Cardiol)"},{"key":"10.1016\/j.ijcchd.2026.100688_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","article-title":"Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study","volume":"114","author":"Gali\u00e8","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcchd.2026.100688_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031760","article-title":"Arrhythmia burden among adult patients with congenital heart disease: a population\u2010based Study","volume":"13","author":"Schamroth Pravda","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ijcchd.2026.100688_bib25","doi-asserted-by":"crossref","DOI":"10.1001\/jamahealthforum.2023.1921","article-title":"Spending on phased clinical development of approved drugs by the US national Institutes of health compared with industry","volume":"4","author":"Zhou","year":"2023","journal-title":"JAMA Health Forum"},{"key":"10.1016\/j.ijcchd.2026.100688_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/1740774515626362","article-title":"Efficiencies of platform clinical trials: a vision of the future","volume":"13","author":"Saville","year":"2016","journal-title":"Clin Trials"},{"key":"10.1016\/j.ijcchd.2026.100688_bib27","first-page":"125","article-title":"An overview of precision oncology basket and umbrella trials for clinicians","volume":"70","author":"Park","year":"2020","journal-title":"CA Cancer J Clin"}],"container-title":["International Journal of Cardiology Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668526000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666668526000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:49:33Z","timestamp":1789199373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666668526000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S2666668526000376"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcchd.2026.100688","relation":{},"ISSN":["2666-6685"],"issn-type":[{"value":"2666-6685","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bibliometric analysis of medication studies in congenital heart disease","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Congenital Heart Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcchd.2026.100688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100688"}}