{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:01:52Z","timestamp":1791525712120,"version":"4.3.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart &amp; Vasculature"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijcha.2018.10.003","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T13:01:13Z","timestamp":1541682073000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Evaluation of a guideline directed medical therapy titration program in patients with heart failure with reduced ejection fraction"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-4154","authenticated-orcid":false,"given":"Kathir","family":"Balakumaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadhar","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ingrassia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Louis","family":"Jacoby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeena","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-2082","authenticated-orcid":false,"given":"Richard","family":"Soucier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.ijcha.2018.10.003_bb0005","article-title":"ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2018.10.003_bb0010","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"Yancy","year":"2017","journal-title":"Circulation"},{"issue":"9145","key":"10.1016\/j.ijcha.2018.10.003_bb0015","first-page":"9","article-title":"The cardiac insufficiency Bisoprolol study II (CIBIS-II): a randomized trial","volume":"353","author":"CIBIS-II Writers","year":"1999","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.ijcha.2018.10.003_bb0020","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJMoa010713","article-title":"A randomized trial of the angiotensin receptor blocker valsartan in chronic heart failure","volume":"345","author":"Cohn","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2018.10.003_bb0025","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: metoprolol CR\/XL randomised intervention trial in congestive heart failure (MERITHF)","volume":"353","author":"MERIT-HF Study Group","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ijcha.2018.10.003_bb0030","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure","volume":"334","author":"Packer","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"17","key":"10.1016\/j.ijcha.2018.10.003_bb0035","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1161\/01.CIR.0000035653.72855.BF","article-title":"Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study","volume":"106","author":"Packer","year":"2002","journal-title":"Circulation"},{"issue":"9386","key":"10.1016\/j.ijcha.2018.10.003_bb0040","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(03)14284-5","article-title":"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-alternative trial","volume":"362","author":"Granger","year":"2003","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ijcha.2018.10.003_bb0045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ijcha.2018.10.003_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.ijcha.2018.10.003_bb0055","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ejhf.510","article-title":"Physicians' adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from QUALIFY global survey","volume":"18","author":"Komajda","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.ijcha.2018.10.003_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5694\/j.1326-5377.2004.tb06178.x","article-title":"Barriers to diagnosing and managing heart failure in primary care","volume":"181","author":"Phillips","year":"2004","journal-title":"Med. J. Aust."},{"issue":"20","key":"10.1016\/j.ijcha.2018.10.003_bb0065","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.jacc.2017.03.563","article-title":"Achieving a maximally tolerated beta-blocker dose in heart failure patients: is there room for improvement?","volume":"69","author":"Bhatt","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.ijcha.2018.10.003_bb0070","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jacc.2015.12.045","article-title":"Gaps in adherence to guideline-directed medical therapy before defibrillator implantation","volume":"67","author":"Fonarow","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2018.10.003_bb0075","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-7-668","article-title":"A nurse-led up-titration clinic improves chronic heart failure optimization of beta-adrenergic receptor blocking therapy\u2014a randomized controlled trial","volume":"7","author":"Driscoll","year":"2014","journal-title":"BMC Res Notes."},{"issue":"7","key":"10.1016\/j.ijcha.2018.10.003_bb0080","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jamacardio.2016.2332","article-title":"Nurse-led titration of angiotensin-converting enzyme inhibitors, beta-adrenergic blocking agents, and angiotensin receptor blockers in patients with heart failure with reduced ejection fraction","volume":"1","author":"Driscoll","year":"2016","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.ijcha.2018.10.003_bb0085","article-title":"Nurse-led titration of angiotensin converting enzyme inhibitors, beta-adrenergic blocking agents, and angiotensin receptor blockers for people with heart failure with reduced ejection fraction","volume":"12","author":"Driscoll","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijcha.2018.10.003_bb0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ejheart.2004.09.009","article-title":"Success of a multidisciplinary heart failure clinic for initiation and up-titration of key therapeutic agents","volume":"7","author":"Jain","year":"2005","journal-title":"Eur. J. Heart Fail."},{"issue":"22","key":"10.1016\/j.ijcha.2018.10.003_bb0095","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1161\/01.CIR.0000070952.08969.5B","article-title":"Improving guideline adherence: a randomized trial evaluating strategies to increase beta-blocker use in heart failure","volume":"107","author":"Ansari","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2018.10.003_bb0100","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejcnurse.2006.04.002","article-title":"Heart failure management programmes in Europe","volume":"5","author":"Jaarsma","year":"2006","journal-title":"Eur. J. Cardiovasc. Nurs."}],"container-title":["IJC Heart &amp; Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906718301118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906718301118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T23:57:24Z","timestamp":1572566244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906718301118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":20,"alternative-id":["S2352906718301118"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2018.10.003","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of a guideline directed medical therapy titration program in patients with heart failure with reduced ejection fraction","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2018.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}