{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:10:25Z","timestamp":1762492225713,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015639","name":"Japan Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPA18H04050","JPB15H04826"],"award-info":[{"award-number":["JPA18H04050","JPB15H04826"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart &amp; Vasculature"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ijcha.2019.100396","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T23:41:47Z","timestamp":1562715707000},"page":"100396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs"],"prefix":"10.1016","volume":"24","author":[{"given":"Hiroko","family":"Takahama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Asanuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kitakaze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcha.2019.100396_bb0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00109-012-0988-7","article-title":"Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease","volume":"91","author":"Poth","year":"2013","journal-title":"J Mol Med (Berl)."},{"key":"10.1016\/j.ijcha.2019.100396_bb0010","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.4049\/jimmunol.178.12.8127","article-title":"Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury","volume":"178","author":"Eckle","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0015","first-page":"1625","article-title":"Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation","volume":"229","author":"Mentzer","year":"1975","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0020","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1182\/blood-2007-10-117044","article-title":"A2B adenosine receptor dampens hypoxia-induced vascular leak","volume":"111","author":"Eckle","year":"2008","journal-title":"Blood."},{"key":"10.1016\/j.ijcha.2019.100396_bb0025","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1182\/blood-2004-06-2066","article-title":"Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism","volume":"104","author":"Eltzschig","year":"2004","journal-title":"Blood."},{"key":"10.1016\/j.ijcha.2019.100396_bb0030","first-page":"298","article-title":"Role of extracellular adenosine in acute lung injury","volume":"24","author":"Eckle","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.ijcha.2019.100396_bb0035","first-page":"H1862","article-title":"Adenosine-induced vasodilation: receptor characterization in pulmonary circulation","volume":"268","author":"Haynes","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0040","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.CIR.84.3.1145","article-title":"Adenosine as a vasodilator in primary pulmonary hypertension","volume":"84","author":"Morgan","year":"1991","journal-title":"Circulation."},{"key":"10.1016\/j.ijcha.2019.100396_bb0045","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1161\/CIRCULATIONAHA.104.503540","article-title":"Pulmonary arterial hypertension","volume":"114","author":"McLaughlin","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.ijcha.2019.100396_bb0050","first-page":"H200","article-title":"Adenosine A1 and A2 receptors mediate tone-dependent responses in feline pulmonary vascular bed","volume":"270","author":"Cheng","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(00)00168-1","article-title":"Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction","volume":"48","author":"Smulders","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcha.2019.100396_bb0060","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s10439-014-1011-y","article-title":"Hypoxic pulmonary vasoconstriction as a contributor to response in acute pulmonary embolism","volume":"42","author":"Burrowes","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.ijcha.2019.100396_bb0065","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1097\/CCM.0b013e318226678e","article-title":"Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543","volume":"39","author":"Watts","year":"2011","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ijcha.2019.100396_bb0070","doi-asserted-by":"crossref","first-page":"H1731","DOI":"10.1152\/ajpheart.00336.2006","article-title":"Quantification of right ventricular afterload in patients with and without pulmonary hypertension","volume":"291","author":"Lankhaar","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0075","first-page":"C799","article-title":"Turnover of adenosine in plasma of human and dog blood","volume":"256","author":"Moser","year":"1989","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/shk.0b013e318070c790","article-title":"Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading","volume":"29","author":"Ghuysen","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.ijcha.2019.100396_bb0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1378\/chest.121.3.877","article-title":"Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism","volume":"121","author":"Wood","year":"2002","journal-title":"Chest."},{"key":"10.1016\/j.ijcha.2019.100396_bb0090","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/CIRCULATIONAHA.106.620872","article-title":"Acute pulmonary embolism: part I: epidemiology and diagnosis","volume":"114","author":"Piazza","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.ijcha.2019.100396_bb0095","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0002-9149(97)00256-7","article-title":"Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology","volume":"79","author":"Shryock","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0100","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2013.06.002","article-title":"Cardiovascular adenosine receptors: expression, actions and interactions","volume":"140","author":"Headrick","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcha.2019.100396_bb0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/jmcc.1999.1077","article-title":"Myocardial oxygen consumption modulates adenosine formation by canine right ventricle in absence of hypoxia","volume":"32","author":"Bian","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0022-2828(78)90352-8","article-title":"Increased adenosine formation by rat myocardium with acute aortic constriction","volume":"10","author":"Foley","year":"1978","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0115","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1172\/JCI115671","article-title":"Energetics of acute pressure overload of the porcine right ventricle. In vivo 31P nuclear magnetic resonance","volume":"89","author":"Schwartz","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcha.2019.100396_bb0120","first-page":"H521","article-title":"Relation among regional O2 consumption, high-energy phosphates, and substrate uptake in porcine right ventricle","volume":"266","author":"Schwartz","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0125","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/clinchem\/38.2.256","article-title":"Improved detection of ischemia-induced increases in coronary sinus adenosine in patients with coronary artery disease","volume":"38","author":"Feldman","year":"1992","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcha.2019.100396_bb0130","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1161\/01.CIR.91.3.838","article-title":"Metabolic determinants of defibrillation. Role of adenosine","volume":"91","author":"Lerman","year":"1995","journal-title":"Circulation."},{"key":"10.1016\/j.ijcha.2019.100396_bb0135","first-page":"H24","article-title":"Relationships between adenosine and coronary resistance in conscious exercising dogs","volume":"242","author":"McKenzie","year":"1982","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0140","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1152\/japplphysiol.00457.2010","article-title":"Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise","volume":"109","author":"La Gerche","year":"2010","journal-title":"J Appl Physiol (1985)."},{"key":"10.1016\/j.ijcha.2019.100396_bb0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pharmthera.2008.04.003","article-title":"Control of pulmonary vascular tone during exercise in health and pulmonary hypertension","volume":"119","author":"Merkus","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcha.2019.100396_bb0150","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/j.2040-4603.2012.tb00405.x","article-title":"Pulmonary circulation at exercise","volume":"2","author":"Naeije","year":"2012","journal-title":"Compr Physiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0155","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2009.03.061","article-title":"Sympathetic nervous system activation in human heart failure: clinical implications of an updated model","volume":"54","author":"Floras","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2019.100396_bb0160","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1093\/eurheartj\/ehn310","article-title":"Guidelines on the diagnosis and management of acute pulmonary embolism: the task force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)","volume":"29","author":"Torbicki","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcha.2019.100396_bb0165","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1152\/jappl.1989.66.5.2079","article-title":"Site of recruitment in the pulmonary microcirculation","volume":"66","author":"Hanson","year":"1989","journal-title":"J Appl Physiol (1985)."},{"key":"10.1016\/j.ijcha.2019.100396_bb0170","first-page":"L73","article-title":"Pulmonary arterial hypoxic contraction: signal transduction","volume":"263","author":"Jin","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0175","first-page":"H541","article-title":"Adenosine and hypoxic pulmonary vasodilation","volume":"247","author":"Gottlieb","year":"1984","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0180","first-page":"H1663","article-title":"Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise","volume":"275","author":"Duncker","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcha.2019.100396_bb0185","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0163-7258(01)00152-8","article-title":"Pharmacology of adenosine receptors in the vasculature","volume":"91","author":"Tabrizchi","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcha.2019.100396_bb0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrd3955","article-title":"Adenosine receptors as drug targets\u2014what are the challenges?","volume":"12","author":"Chen","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijcha.2019.100396_bb0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pupt.2011.10.005","article-title":"Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism","volume":"25","author":"Watts","year":"2012","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ijcha.2019.100396_bb0200","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1097\/CCM.0b013e31827c0b43","article-title":"Elevated plasma hemoglobin levels increase nitric oxide consumption in experimental and clinical acute pulmonary thromboembolism","volume":"41","author":"Sertorio","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ijcha.2019.100396_bb0205","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/j.1538-7836.2009.03535.x","article-title":"Reduction in plasma haptoglobin in humans with acute pulmonary embolism causing tricuspid regurgitation","volume":"7","author":"Kline","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcha.2019.100396_bb0210","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nm.2280","article-title":"Detrimental effects of adenosine signaling in sickle cell disease","volume":"17","author":"Zhang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcha.2019.100396_bb0215","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.mehy.2008.12.043","article-title":"Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension","volume":"72","author":"Tofovic","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ijcha.2019.100396_bb0220","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/0024-3205(81)90721-9","article-title":"Adenosine metabolism in dog whole blood: effects of dipyridamole","volume":"28","author":"Klabunde","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcha.2019.100396_bb0225","doi-asserted-by":"crossref","first-page":"H1633","DOI":"10.1152\/ajpheart.00575.2004","article-title":"Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease","volume":"288","author":"Sato","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["IJC Heart &amp; Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906719300909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906719300909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:08:19Z","timestamp":1762492099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906719300909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":45,"alternative-id":["S2352906719300909"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2019.100396","relation":{},"ISSN":["2352-9067"],"issn-type":[{"type":"print","value":"2352-9067"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2019.100396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100396"}}