{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:00:36Z","timestamp":1774353636749,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart &amp; Vasculature"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ijcha.2022.100997","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T06:53:30Z","timestamp":1647327210000},"page":"100997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Microvascular dysfunction of the non-culprit circulation predicts poor prognosis in patients with ST-segment elevation myocardial infarction"],"prefix":"10.1016","volume":"39","author":[{"given":"Cristian Herrera","family":"Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"D\u00edez-Delhoyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Sanz-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"V\u00e1zquez-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Tamargo Delpon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Soriano Triguero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"El\u00edzaga Corrales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Guti\u00e9rrez Iba\u00f1es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ijcha.2022.100997_b0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcha.2022.100997_b0010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/cvr\/cvz301","article-title":"Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction","volume":"116","author":"Konijnenberg","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.ijcha.2022.100997_b0015","article-title":"Prevalence of microvascular and endothelial dysfunction in the nonculprit territory in patients with acute myocardial infarction: the FISIOIAM study","volume":"12","author":"D\u00edez-Delhoyo","year":"2019","journal-title":"Circ. Cardiovasc. Int."},{"issue":"8","key":"10.1016\/j.ijcha.2022.100997_b0020","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/jamacardio.2019.2138","article-title":"Temporal changes in coronary hyperemic and resting hemodynamic indices in nonculprit vessels of patients with ST-segment elevation myocardial infarction","volume":"4","author":"van der Hoeven","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"2","key":"10.1016\/j.ijcha.2022.100997_b0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.atherosclerosis.2005.01.007","article-title":"High frequency of endothelial vasomotor dysfunction after acute coronary syndromes in non-culprit and angiographically normal coronary arteries: a reversible phenomenon","volume":"181","author":"Elbaz","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcha.2022.100997_b0030","doi-asserted-by":"crossref","unstructured":"M.A. Kelshiker, H. Seligman, J.P. Howard et al., Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis, Eur. Heart J. Published online November 24, 2021. doi:10.1093\/eurheartj\/ehab775.","DOI":"10.1093\/eurheartj\/ehab775"},{"issue":"5","key":"10.1016\/j.ijcha.2022.100997_b0035","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.amjcard.2008.10.033","article-title":"Additive prognostic value of coronary flow reserve in patients with chest pain syndrome and normal or near-normal coronary arteries","volume":"103","author":"Sicari","year":"2009","journal-title":"Am. J. Cardiol."},{"issue":"10","key":"10.1016\/j.ijcha.2022.100997_b0040","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jacc.2015.12.053","article-title":"Coronary flow reserve and microcirculatory resistance in patients with intermediate coronary stenosis","volume":"67","author":"Lee","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcha.2022.100997_b0045","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.amjcard.2007.04.015","article-title":"Usefulness of coronary flow reserve immediately after primary coronary angioplasty for acute myocardial infarction in predicting long-term adverse cardiac events","volume":"100","author":"Takahashi","year":"2007","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcha.2022.100997_b0050","first-page":"207","article-title":"Impact of coronary microvascular function on long-term cardiac mortality in patients with acute ST-segment-elevation myocardial infarction","volume":"6","author":"van de Hoef","year":"2013","journal-title":"Circ. Cardiovasc. Int."},{"issue":"6","key":"10.1016\/j.ijcha.2022.100997_b0055","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jcin.2016.01.001","article-title":"Changes in coronary blood flow after acute myocardial infarction: insights from a patient study and an experimental porcine model","volume":"9","author":"de Waard","year":"2016","journal-title":"JACC Cardiovasc. Int."},{"issue":"23","key":"10.1016\/j.ijcha.2022.100997_b0060","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1161\/CIRCULATIONAHA.116.022603","article-title":"Comparative prognostic utility of indexes of microvascular function alone or in combination in patients with an acute ST-segment-elevation myocardial infarction","volume":"134","author":"Carrick","year":"2016","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.ijcha.2022.100997_b0065","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1161\/CIRCULATIONAHA.112.000298","article-title":"Prognostic value of the index of microcirculatory resistance measured after primary percutaneous coronary intervention","volume":"127","author":"Fearon","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ijcha.2022.100997_b0070","first-page":"149","article-title":"Thermodilution-derived coronary blood flow pattern immediately after coronary intervention as a predictor of microcirculatory damage and midterm clinical outcomes in patients with st-segment-elevation myocardial infarction","volume":"7","author":"Fukunaga","year":"2014","journal-title":"Circ. Cardiovasc. Int."},{"issue":"1","key":"10.1016\/j.ijcha.2022.100997_b0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MCA.0000000000000310","article-title":"Comprehensive assessment of microcirculation after primary percutaneous intervention in ST-segment elevation myocardial infarction: Insight from thermodilution-derived index of microcirculatory resistance and coronary flow reserve","volume":"27","author":"Park","year":"2016","journal-title":"Coron. Art. Dis."},{"issue":"6","key":"10.1016\/j.ijcha.2022.100997_b0080","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacc.2018.11.040","article-title":"Impact of abnormal coronary reactivity on long-term clinical outcomes in women","volume":"73","author":"AlBadri","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.ijcha.2022.100997_b0085","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.recesp.2015.12.020","article-title":"Endothelial dysfunction after ST-segment elevation myocardial infarction and long-term outcome: a study with reactive hyperemia peripheral artery tonometry","volume":"69","author":"Kandhai-Ragunath","year":"2016","journal-title":"Rev. Espa\u00f1ol. Cardiol. (English Ed.)"},{"issue":"4","key":"10.1016\/j.ijcha.2022.100997_b0090","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00380-020-01723-9","article-title":"Impact of persistent endothelial dysfunction in an infarct-related coronary artery on future major adverse cardiovascular event occurrence in STEMI survivors","volume":"36","author":"Horikoshi","year":"2021","journal-title":"Heart Vess."},{"issue":"41","key":"10.1016\/j.ijcha.2022.100997_b0095","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1093\/eurheartj\/eht351","article-title":"Endothelial dysfunction over the course of coronary artery disease","volume":"34","author":"Gutierrez","year":"2013","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.ijcha.2022.100997_b0100","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJMoa1305520","article-title":"Randomized trial of preventive angioplasty in myocardial infarction","volume":"369","author":"Wald","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"25","key":"10.1016\/j.ijcha.2022.100997_b0105","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.jacc.2019.10.033","article-title":"Complete versus lesion-only revascularization in patients with STEMI and multivessel disease: the CvLPRIT trial","volume":"74","author":"Gershlick","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"15","key":"10.1016\/j.ijcha.2022.100997_b0110","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJMoa1907775","article-title":"Complete revascularization with multivessel PCI for myocardial infarction","volume":"381","author":"Mehta","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"9994","key":"10.1016\/j.ijcha.2022.100997_b0115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0140-6736(15)60648-1","article-title":"Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3 \u2013 PRIMULTI): an open-label, randomised controlled trial","volume":"386","author":"Engstr\u00f8m","year":"2015","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.ijcha.2022.100997_b0120","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJMoa1701067","article-title":"Fractional flow reserve-guided multivessel angioplasty in myocardial infarction","volume":"376","author":"Smits","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcha.2022.100997_b0125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJMoa2104650","article-title":"Multivessel PCI guided by FFR or angiography for myocardial infarction","volume":"385","author":"Puymirat","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.ijcha.2022.100997_b0130","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.jcin.2018.07.012","article-title":"Optical coherence tomography-defined plaque vulnerability in relation to functional stenosis severity and microvascular dysfunction","volume":"11","author":"Usui","year":"2018","journal-title":"JACC Cardiovasc. Int."},{"issue":"4","key":"10.1016\/j.ijcha.2022.100997_b0135","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.recesp.2019.08.016","article-title":"Prevalence of OCT-defined high-risk plaque in relation to physiological characteristics by fractional flow reserve and coronary flow reserve","volume":"73","author":"Hoshino","year":"2020","journal-title":"Rev. Espa\u00f1ola Cardiol. (English Ed.)"}],"container-title":["IJC Heart &amp; Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672200046X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672200046X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:12:57Z","timestamp":1762492377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235290672200046X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":27,"alternative-id":["S235290672200046X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2022.100997","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microvascular dysfunction of the non-culprit circulation predicts poor prognosis in patients with ST-segment elevation myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2022.100997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100997"}}