{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:26Z","timestamp":1793726066047,"version":"4.6.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008309","name":"Johns Hopkins Bloomberg School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI107028-01A1"],"award-info":[{"award-number":["1R01AI107028-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ijcha.2022.101060","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T14:30:19Z","timestamp":1653316219000},"page":"101060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-0900","authenticated-orcid":false,"given":"Sithu","family":"Win","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Miranda-Schaeubinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Gustavo Dur\u00e1n Saucedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Carballo Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Mercado-Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Camila Telleria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Raafs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Verastegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn","family":"Bern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Tinajeros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcha.2022.101060_b0005","first-page":"33","article-title":"an epidemiological update based on 2010 estimates","volume":"90","author":"Chagas disease in Latin America","year":"2015","journal-title":"Wkly. Epidemiol. Rec."},{"key":"10.1016\/j.ijcha.2022.101060_b0010","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"Bern","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijcha.2022.101060_b0015","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association","volume":"138","author":"Nunes","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2022.101060_b0020","doi-asserted-by":"crossref","first-page":"e688","DOI":"10.1371\/journal.pntd.0000688","article-title":"Chagas cardiomyopathy in the context of the chronic disease transition","volume":"4","author":"Hidron","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijcha.2022.101060_b0025","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMct1014204","article-title":"Antitrypanosomal therapy for chronic Chagas\u2019 disease","volume":"364","author":"Bern","year":"2011","journal-title":"N.Engl. J. Med."},{"key":"10.1016\/j.ijcha.2022.101060_b0030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.7326\/0003-4819-144-10-200605160-00006","article-title":"Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial","volume":"144","author":"Viotti","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcha.2022.101060_b0035","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized Trial of Benznidazole for Chronic Chagas\u2019 Cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2022.101060_b0040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas\u2019 Disease","volume":"373","author":"Bern","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2022.101060_b0045","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ijcha.2022.101060_b0050","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas heart disease","volume":"115","author":"Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2022.101060_b0055","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/clc.4960231205","article-title":"Chagas\u2019 heart disease","volume":"23","author":"Rassi","year":"2000","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ijcha.2022.101060_b0060","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/01.CIR.75.6.1140","article-title":"Cardiac morbidity and mortality due to Chagas\u2019 disease: prospective electrocardiographic study of a Brazilian community","volume":"75","author":"Maguire","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2022.101060_b0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1473-3099(01)00065-2","article-title":"Clinical and epidemiological aspects of Chagas disease","volume":"1","author":"Prata","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijcha.2022.101060_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0066-782X2011001600001","article-title":"I Latin American guidelines for the diagnosis and treatment of Chagas cardiomyopathy","volume":"97","author":"de Andrade","year":"2011","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.ijcha.2022.101060_b0075","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCULATIONAHA.106.627323","article-title":"Echocardiography in Chagas heart disease","volume":"115","author":"Acquatella","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2022.101060_b0080","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcha.2022.101060_b0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcha.2022.101060_b0090","unstructured":"StataCorp. 2015. Stata Statistical Software: Release 14. College Station. ;TX: StataCorp LP."},{"key":"10.1016\/j.ijcha.2022.101060_b0095","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4269\/ajtmh.1982.31.42","article-title":"A three-year follow-up study of infection with Trypanosoma cruzi and electrocardiographic abnormalities in a rural community in northeast Brazil","volume":"31","author":"Maguire","year":"1982","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijcha.2022.101060_b0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jelectrocard.2011.04.011","article-title":"The prognostic significance of electrocardiographic changes in Chagas disease","volume":"45","author":"Nascimento","year":"2012","journal-title":"J. Electrocardiol."},{"key":"10.1016\/j.ijcha.2022.101060_b0105","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.jacc.2005.01.071","article-title":"Significance of QRS complex duration in patients with heart failure","volume":"46","author":"Kashani","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2022.101060_b0110","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cardfail.2011.08.007","article-title":"Myocardial deformation analysis in Chagas heart disease with the use of speckle tracking echocardiography","volume":"17","author":"Garc\u00eda-\u00c1lvarez","year":"2011","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcha.2022.101060_b0115","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.echo.2016.03.007","article-title":"Analysis of Regional Left Ventricular Strain in Patients with Chagas Disease and Normal Left Ventricular Systolic Function","volume":"29","author":"Gomes","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcha.2022.101060_b0120","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.echo.2017.01.010","article-title":"Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging","volume":"30","author":"Moreira","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcha.2022.101060_b0125","doi-asserted-by":"crossref","unstructured":"Santos Junior OR, da Costa Rocha MO, Rodrigues de Almeida F, et al. Speckle tracking echocardiographic deformation indices in Chagas and idiopathic dilated cardiomyopathy: Incremental prognostic value of longitudinal strain. PLoS One 2019;14:e0221028. doi:10.1371\/journal.pone.0221028.","DOI":"10.1371\/journal.pone.0221028"},{"key":"10.1016\/j.ijcha.2022.101060_b0130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.echo.2017.06.010","article-title":"Left Ventricular Global Strain Analysis by Two-Dimensional Speckle-Tracking Echocardiography: The Learning Curve","volume":"30","author":"Chan","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcha.2022.101060_b0135","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ehjci\/jex140","article-title":"Echocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study","volume":"18","author":"Sugimoto","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcha.2022.101060_b0140","first-page":"249","article-title":"Evaluation of cardiac function by radioisotopic angiography, in patients with chronic Chagas cardiopathy","volume":"45","author":"Kuschnir","year":"1985","journal-title":"Arq. Bras. Cardiol."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906722001099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906722001099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:12:25Z","timestamp":1762492345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906722001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":28,"alternative-id":["S2352906722001099"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2022.101060","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2022.101060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101060"}}