{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:16:32Z","timestamp":1762492592050,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023177","name":"Fondation Pierre Mercier pour la Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023177","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ijcha.2023.101179","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T23:12:34Z","timestamp":1674947554000},"page":"101179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Long QT: Time to cut cholesterol?"],"prefix":"10.1016","volume":"45","author":[{"given":"Jin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavien","family":"Charpentier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-7430","authenticated-orcid":false,"given":"Ange","family":"Maguy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcha.2023.101179_b0005","first-page":"687","article-title":"Congenital Long QT Syndrome","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC: Clin. Electrophysiol."},{"key":"10.1016\/j.ijcha.2023.101179_b0010","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tcm.2019.08.007","article-title":"Arrhythmogenic foods - a growing medical problem","volume":"30","author":"Woosley","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ijcha.2023.101179_b0015","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cjco.2022.05.001","article-title":"Profound Elevation in LDL Cholesterol Level Following a Ketogenic Diet: a Case Series","volume":"4","author":"Crosier","year":"2022","journal-title":"CJC Open"},{"key":"10.1016\/j.ijcha.2023.101179_b0020","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.cardiores.2005.11.013","article-title":"Involvement of lipid rafts and caveolae in cardiac ion channel function","volume":"69","author":"Maguy","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcha.2023.101179_b0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/j.2040-4603.2012.tb00406.x","article-title":"Regulation of ion channels by membrane lipids","volume":"2","author":"Rosenhouse-Dantsker","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ijcha.2023.101179_b0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4161\/chan.4946","article-title":"Kv11.1 (ERG1) K + Channels Localize in Cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol","volume":"1","author":"Balijepalli","year":"2007","journal-title":"Channels"},{"key":"10.1016\/j.ijcha.2023.101179_b0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4161\/chan.25122","article-title":"Cholesterol regulates HERG K+ channel activation by increasing phospholipase C \u03b21 expression","volume":"7","author":"Chun","year":"2013","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.ijcha.2023.101179_b0040","first-page":"847","article-title":"Effect of hyperlipidemia on QT dispersion in patients without ischemic heart disease","volume":"21","author":"Szab\u00f3","year":"2005","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ijcha.2023.101179_b0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1751-7176.2009.00224.x","article-title":"Association of increased QTc interval with the cardiometabolic syndrome","volume":"12","author":"Grandinetti","year":"2010","journal-title":"J. Clin. Hypertens (Greenwich)"},{"key":"10.1016\/j.ijcha.2023.101179_b0050","doi-asserted-by":"crossref","first-page":"RC16","DOI":"10.1007\/BF03345487","article-title":"Simvastatin normalizes qtc dispersion and reduces ventricular electrical instability in isolated hypercholesterolemia","volume":"25","author":"Gualdieroi","year":"2002","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.ijcha.2023.101179_b0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijcard.2008.11.030","article-title":"Statin therapy shortens QTc, QTcd, and improves cardiac function in patients with chronic heart failure","volume":"140","author":"Xie","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcha.2023.101179_b0060","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/jps.22809","article-title":"Rosuvastatin blocks hERG current and prolongs cardiac repolarization","volume":"101","author":"Plante","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijcha.2023.101179_b0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jacc.2010.11.072","article-title":"Reconstituted high-density lipoprotein shortens cardiac repolarization","volume":"58","author":"Den Ruijter","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2023.101179_b0070","doi-asserted-by":"crossref","first-page":"E1527","DOI":"10.3390\/jcm8101527","article-title":"Association Between HDL Cholesterol and QTc Interval: a population-based epidemiological study","volume":"8","author":"Del Giorno","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijcha.2023.101179_b0075","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2020.02.067","article-title":"KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2","volume":"75","author":"Maguy","year":"2020","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906723000106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906723000106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:12:15Z","timestamp":1762492335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906723000106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":15,"alternative-id":["S2352906723000106"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2023.101179","relation":{},"ISSN":["2352-9067"],"issn-type":[{"type":"print","value":"2352-9067"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long QT: Time to cut cholesterol?","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2023.101179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101179"}}