{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:16:34Z","timestamp":1790612194221,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011583","name":"Kansas Academy of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011583","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015421","name":"Johnson Cancer Research Center, Kansas State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL134643"],"award-info":[{"award-number":["T32 HL134643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017749","name":"Cardiovascular Center, Medical College of Wisconsin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ijcha.2023.101300","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:07:14Z","timestamp":1700248034000},"page":"101300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-5554","authenticated-orcid":false,"given":"Stephen T.","family":"Hammond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dryden R.","family":"Baumfalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon K.","family":"Parr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec L.E.","family":"Butenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton C.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa-Rose G.","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmood H.","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Ade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcha.2023.101300_b0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0284186X.2019.1711164","article-title":"Incidence and risk markers of 5-fluorouracil and capecitabine cardiotoxicity in patients with colorectal cancer","volume":"59","author":"Dyhl-Polk","year":"2020","journal-title":"Acta Oncol (madr)."},{"key":"10.1016\/j.ijcha.2023.101300_b0010","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ctrv.2013.03.005","article-title":"Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: A systematic review of incidence, manifestations and predisposing factors","volume":"39","author":"Polk","year":"2013","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.ijcha.2023.101300_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1758835918780140","article-title":"5-fluorouracil and cardiotoxicity: a review","volume":"10","author":"Sara","year":"2018","journal-title":"Ther Adv Med Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0020","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3390\/jcm11051244","article-title":"The Role of Vasospasm and Microcirculatory Dysfunction in Fluoropyrimidine-Induced Ischemic Heart Disease","volume":"11","author":"Fabin","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijcha.2023.101300_b0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000072334","article-title":"High Incidence of Angina pectoris in Patients Treated with 5-Fluorouracil","volume":"65","author":"Wacker","year":"2003","journal-title":"Oncology"},{"key":"10.1016\/j.ijcha.2023.101300_b0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0167-8140(88)90296-4","article-title":"Adverse cardiac effects during induction chemotherapy treatment with cis-platin and 5-fluorouracil","volume":"13","author":"Eskilsson","year":"1988","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0035","article-title":"A retrospective study of cardiotoxicities induced by 5-Fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center","volume":"62","author":"Khan","year":"2012","journal-title":"J Pak Med Assoc."},{"key":"10.1016\/j.ijcha.2023.101300_b0040","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/annonc\/mdu055","article-title":"Effort myocardial ischemia during chemotherapy with 5-fluorouracil: an underestimated risk","volume":"25","author":"Lestuzzi","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0045","doi-asserted-by":"crossref","first-page":"e1254","DOI":"10.1634\/theoncologist.2020-0053","article-title":"Fluoropyrimidine-Associated Cardiotoxicity: Probably Not So Rare As It Seems","volume":"25","author":"Lestuzzi","year":"2020","journal-title":"Oncologist."},{"key":"10.1016\/j.ijcha.2023.101300_b0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1200\/JCO.1989.7.4.509","article-title":"Continuous ambulatory ECG monitoring during fluorouracil therapy: A prospective study","volume":"7","author":"Rezkalla","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0055","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00280-019-03888-1","article-title":"Incidence of and risk factors for cardiotoxicity after fluorouracil-based chemotherapy in locally advanced or metastatic gastric cancer patients","volume":"84","author":"Jin","year":"2019","journal-title":"Cancer Chemother Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0060","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1056\/NEJM199504063321401","article-title":"Adjuvant Cyclophosphamide, Methotrexate, and Fluorouracil in Node-Positive Breast Cancer \u2014 The Results of 20 Years of Follow-up","volume":"332","author":"Bonadonna","year":"1995","journal-title":"N Engl J Med."},{"key":"10.1016\/j.ijcha.2023.101300_b0065","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0959-8049(98)00209-3","article-title":"Dose-response effect of adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) in node-positive breast cancer. International Breast Cancer Study Group","volume":"34","author":"Colleoni","year":"1998","journal-title":"Eur J Cancer."},{"key":"10.1016\/j.ijcha.2023.101300_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1038-y","article-title":"Adjuvant chemotherapy for stage III colon cancer: Relative dose intensity and survival among veterans","volume":"15","author":"Aspinall","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijcha.2023.101300_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2050-6511-15-47","article-title":"A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity","volume":"15","author":"Polk","year":"2014","journal-title":"BMC Pharmacol Toxicol."},{"key":"10.1016\/j.ijcha.2023.101300_b0080","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/oxfordjournals.eurheartj.a059919","article-title":"Coronary artery spasm induced by 5-fluorouracil","volume":"12","author":"Luwaert","year":"1991","journal-title":"Eur Heart J."},{"key":"10.1016\/j.ijcha.2023.101300_b0085","first-page":"46","volume":"11","author":"Shoemaker","year":"2017","journal-title":"5-Fluorouracil\u2013induced Coronary Vasospasm."},{"key":"10.1016\/j.ijcha.2023.101300_b0090","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/annonc\/mdh150","article-title":"5-Fluorouracil induces arterial vasocontractions","volume":"15","author":"S\u00fcdhoff","year":"2004","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0095","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1152\/japplphysiol.00394.2018","article-title":"Lower cutaneous microvascular reactivity in adult cancer patients receiving chemotherapy","volume":"125","author":"Sutterfield","year":"2018","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40959-021-00104-z","article-title":"Lower endothelium-dependent microvascular function in adult breast cancer patients receiving radiation therapy","volume":"7","author":"Banister","year":"2021","journal-title":"Cardio-Oncology."},{"key":"10.1016\/j.ijcha.2023.101300_b0105","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1152\/japplphysiol.91508.2008","article-title":"The effect of microdialysis needle trauma on cutaneous vascular responses in humans","volume":"106","author":"Hodges","year":"2009","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.750507","article-title":"Mechanisms of Chemotherapy-Induced Neurotoxicity","volume":"13","author":"Was","year":"2022","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0115","series-title":"Costa R","first-page":"13","author":"Quint\u00e3o","year":"2019"},{"key":"10.1016\/j.ijcha.2023.101300_b0120","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1152\/japplphysiol.01354.2011","article-title":"Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin","volume":"112","author":"Bruning","year":"2012","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0125","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/jappl.2001.91.4.1619","article-title":"Nitric oxide and neurally mediated regulation of skin blood flow during local heating","volume":"91","author":"Minson","year":"2001","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0130","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/japplphysiol.00690.2009","article-title":"Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans","volume":"107","author":"Kellogg","year":"2009","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0135","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1152\/jappl.1999.86.4.1185","article-title":"Role of nitric oxide in the vascular effects of local warming of the skin in humans","volume":"86","author":"Kellogg","year":"1999","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0140","doi-asserted-by":"crossref","first-page":"H425","DOI":"10.1152\/ajpheart.01217.2006","article-title":"Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans","volume":"293","author":"Medow","year":"2007","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology."},{"key":"10.1016\/j.ijcha.2023.101300_b0145","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1161\/CIRCULATIONAHA.104.526764","article-title":"Decreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome","volume":"112","author":"Medow","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2023.101300_b0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1152\/ajpheart.00082.2008","article-title":"Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo","volume":"295","author":"Kellogg","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0155","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1113\/jphysiol.1996.sp021814","article-title":"Heat-evoked vasodilatation in human hairy skin: axon reflexes due to low-level activity of nociceptive afferents","volume":"497","author":"Magerl","year":"1996","journal-title":"J Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0160","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/HYPERTENSIONAHA.111.00991","article-title":"Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidative stress","volume":"62","author":"Wauters","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcha.2023.101300_b0165","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1152\/ajpregu.00448.2012","article-title":"Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms","volume":"304","author":"Alexander","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0170","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/HYPERTENSIONAHA.117.09386","article-title":"Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia","volume":"70","author":"Stanhewicz","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcha.2023.101300_b0175","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1152\/ajprenal.00321.2017","article-title":"Role of mitochondria-derived reactive oxygen species in microvascular dysfunction in chronic kidney disease","volume":"314","author":"Kirkman","year":"2018","journal-title":"Am J Physiol Renal Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0180","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/HYPERTENSIONAHA.111.178129","article-title":"Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans","volume":"58","author":"Smith","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcha.2023.101300_b0185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/FJC.0b013e3182858f81","article-title":"L-NAME iontophoresis: A tool to assess NO-mediated vasoreactivity during thermal hyperemic vasodilation in humans","volume":"61","author":"Dreyfuss","year":"2013","journal-title":"J Cardiovasc Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0190","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1365-2125.1998.00718.x","article-title":"Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide","volume":"45","author":"Noon","year":"1998","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0195","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1113\/jphysiol.2004.080952","article-title":"Mechanisms of acetylcholine-mediated vasodilation in young and aged human skin","volume":"563","author":"Holowatz","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/japplphysiol.00728.2004","article-title":"Acetylcholine-induced vasodilation is mediated by nitric oxide and prostaglandins in human skin","volume":"98","author":"Kellogg","year":"2005","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0205","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1358863X9700200202","article-title":"Cutaneous Vascular Responses to Acetylcholine are Mediated by a Prostanoid-Dependent Mechanism in Man","volume":"2","author":"Khan","year":"1997","journal-title":"Vasc. Med."},{"key":"10.1016\/j.ijcha.2023.101300_b0210","first-page":"312","article-title":"Role of endothelium-derived hyperpolarising factor in acetylcholine-mediated vasodilatation in skin","volume":"32","author":"Newton","year":"2013","journal-title":"Int. Angiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0215","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mvr.2017.04.006","article-title":"Assessing cutaneous microvascular function with iontophoresis: Avoiding non-specific vasodilation","volume":"113","author":"Loader","year":"2017","journal-title":"Microvasc Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0220","article-title":"In Vitro Evidence That Myocardial Ischemia Resulting from 5-Fluorouracil Chemotherapy Is Due to Protein Kinase C-mediated Vasoconstriction of Vascular Smooth Muscle","volume":"53","author":"Mosseri","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0225","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1249\/01.MSS.0000117130.91142.38","article-title":"Training Enhances Vascular Relaxation after Chemotherapy-Induced Vasoconstriction","volume":"36","author":"Hayward","year":"2004","journal-title":"Med Sci Sports Exerc."},{"key":"10.1016\/j.ijcha.2023.101300_b0230","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/oxfordjournals.annonc.a010476","volume":"7","author":"Findlay","year":"1996","journal-title":"Ann Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0235","first-page":"1347","article-title":"High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion","volume":"5","author":"Takimoto","year":"1999","journal-title":"Clin Cancer Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0240","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.phrs.2004.01.006","article-title":"Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients","volume":"50","author":"Casale","year":"2004","journal-title":"Pharmacol Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/bmc.2741","article-title":"LC-MS\/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients","volume":"27","author":"B\u00fcchel","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ijcha.2023.101300_b0250","series-title":"Statistics in kinesiology","author":"Weir","year":"2021"},{"key":"10.1016\/j.ijcha.2023.101300_b0255","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0735-1097(03)00994-X","article-title":"The clinical implications of endothelial dysfunction","volume":"42","author":"Widlansky","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0260","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1161\/01.CIR.86.6.1864","article-title":"Endothelial dysfunction in patients with chest pain and normal coronary arteries","volume":"86","author":"Quyyumi","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2023.101300_b0265","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.CIR.94.3.266","article-title":"Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina","volume":"94","author":"Kugiyama","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2023.101300_b0270","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.92.3.320","article-title":"Contribution of nitric oxide to metabolic coronary vasodilation in the human heart","volume":"92","author":"Quyyumi","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2023.101300_b0275","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1152\/ajpheart.00311.2011","article-title":"Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes","volume":"302","author":"van den Heuvel","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0280","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0735-1097(95)00327-4","article-title":"Close relation of endothelial function in the human coronary and peripheral circulations","volume":"26","author":"Anderson","year":"1995","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0285","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1152\/ajpendo.00365.2006","article-title":"Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus","volume":"292","author":"Sokolnicki","year":"2007","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.1016\/j.ijcha.2023.101300_b0290","doi-asserted-by":"crossref","first-page":"H343","DOI":"10.1152\/ajpheart.00446.2017","article-title":"Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation","volume":"314","author":"Alba","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0295","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mvr.2012.02.002","article-title":"Laser Doppler assessment of dermal circulatory changes in people with coronary artery disease","volume":"84","author":"Agarwal","year":"2012","journal-title":"Microvasc Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0300","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/eurheartj\/ehi655","article-title":"Impaired skin blood flow response to environmental heating in chronic heart failure","volume":"27","author":"Green","year":"2006","journal-title":"Eur Heart J."},{"key":"10.1016\/j.ijcha.2023.101300_b0305","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/annonc\/mdm550","article-title":"Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation","volume":"19","author":"Mourad","year":"2008","journal-title":"Annals of Oncology."},{"key":"10.1016\/j.ijcha.2023.101300_b0310","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/CS20070431","article-title":"Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography","volume":"15","author":"Khan","year":"2008","journal-title":"Clin Sci."},{"key":"10.1016\/j.ijcha.2023.101300_b0315","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1161\/HYPERTENSIONAHA.113.02044","article-title":"Is flow-mediated dilation nitric oxide mediated?: A meta-analysis","volume":"63","author":"Green","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcha.2023.101300_b0320","doi-asserted-by":"crossref","first-page":"H2080","DOI":"10.1152\/ajpheart.00917.2020","article-title":"Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases","volume":"320","author":"Kirkman","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0325","doi-asserted-by":"crossref","first-page":"14693","DOI":"10.1038\/s41598-020-71531-8","article-title":"Activated ROCK\/Akt\/eNOS and ET-1\/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin","volume":"10","author":"Muhammad","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.ijcha.2023.101300_b0330","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1111\/bph.13725","article-title":"5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1","volume":"174","author":"Altieri","year":"2017","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0335","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2011.12.023","article-title":"Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel","volume":"203","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.ijcha.2023.101300_b0340","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol Med."},{"key":"10.1016\/j.ijcha.2023.101300_b0345","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1113\/expphysiol.2011.059907","article-title":"Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus","volume":"96","author":"Carter","year":"2011","journal-title":"Exp Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0350","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/01.RES.0000228471.38761.93","article-title":"COX-2, another important player in the nitric oxide-endothelin cross-talk: Good news for COX-2 inhibitors?","volume":"98","author":"Hink","year":"2006","journal-title":"Circ Res."},{"key":"10.1016\/j.ijcha.2023.101300_b0355","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/oxfordjournals.annonc.a058084","article-title":"Very high endothelin plasma levels in patients with 5-FU cardiotoxicity","volume":"3","author":"Thyss","year":"1992","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ijcha.2023.101300_b0360","first-page":"81","article-title":"Endothelin-1 and 5-fluorouracil-induced cardiotoxicity","volume":"45","author":"Porta","year":"1998","journal-title":"Neoplasma"},{"key":"10.1016\/j.ijcha.2023.101300_b0365","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.taap.2013.03.011","article-title":"Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium","volume":"269","author":"Gajalakshmi","year":"2013","journal-title":"Toxicol Appl Pharmacol."},{"key":"10.1016\/j.ijcha.2023.101300_b0370","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1152\/japplphysiol.00829.2018","article-title":"Effects of prostate cancer and exercise training on left ventricular function and cardiac and skeletal muscle mass","volume":"126","author":"Baumfalk","year":"2018","journal-title":"J Appl Physiol."},{"key":"10.1016\/j.ijcha.2023.101300_b0375","first-page":"10","article-title":"Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging-Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy-Na\u00efve Cancer","author":"Labib","year":"2021","journal-title":"J Am Heart Assoc."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906723001318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906723001318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T09:19:48Z","timestamp":1726910388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906723001318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":75,"alternative-id":["S2352906723001318"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2023.101300","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2023.101300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101300"}}