{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:12:15Z","timestamp":1785841935424,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170497"],"award-info":[{"award-number":["82170497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ijcha.2024.101530","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:12:16Z","timestamp":1728958336000},"page":"101530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dissecting causal relationships between immune cells, blood metabolites, and aortic dissection: A mediation Mendelian randomization study"],"prefix":"10.1016","volume":"55","author":[{"given":"Ao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZiAn","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiHao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhenXiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiYang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9688-9604","authenticated-orcid":false,"given":"ZhiWei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jemermed.2021.10.035","article-title":"Double Aortic Valve Sign in Aortic Dissection","volume":"62","author":"Kapil","year":"2022","journal-title":"J Emerg Med"},{"issue":"2","key":"10.1016\/j.ijcha.2024.101530_b0010","first-page":"238","article-title":"Overview of the current knowledge on etiology, natural history and treatment of aortic dissection","volume":"58","author":"Parve","year":"2017","journal-title":"J Cardiovasc Surg (torino)"},{"issue":"5","key":"10.1016\/j.ijcha.2024.101530_b0015","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1378\/chest.117.5.1271","article-title":"Epidemiology and clinicopathology of aortic dissection","volume":"117","author":"M\u00e9sz\u00e1ros","year":"2000","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ijcha.2024.101530_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14017431.2019.1660401","article-title":"Acute type A aortic dissection - a review","volume":"54","author":"Gudbjartsson","year":"2020","journal-title":"Scand Cardiovasc J"},{"issue":"10","key":"10.1016\/j.ijcha.2024.101530_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/genes13101814","article-title":"Risk Factors for Thoracic Aortic Dissection","volume":"13","author":"Zhou","year":"2022","journal-title":"Genes (basel)"},{"issue":"4","key":"10.1016\/j.ijcha.2024.101530_b0030","doi-asserted-by":"crossref","first-page":"e13697","DOI":"10.1111\/eci.13697","article-title":"The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections","volume":"52","author":"Rombouts","year":"2022","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"10.1016\/j.ijcha.2024.101530_b0035","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezad209","article-title":"Aortic dissection is more violent in the young","volume":"63","author":"Okita","year":"2023","journal-title":"Eur J Cardiothorac Surg"},{"issue":"8","key":"10.1016\/j.ijcha.2024.101530_b0040","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jacc.2019.12.042","article-title":"Aortic Dissection Risk in Marfan Syndrome","volume":"75","author":"Roman","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ijcha.2024.101530_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020182","article-title":"The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective","volume":"10","author":"Ostberg","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijcha.2024.101530_b0050","doi-asserted-by":"crossref","first-page":"6184802","DOI":"10.1155\/2022\/6184802","article-title":"Role of Necroptosis and Immune Infiltration in Human Stanford Type A Aortic Dissection: Novel Insights from Bioinformatics Analyses","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1016\/j.ijcha.2024.101530_b0055","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/jocs.16356","article-title":"The malnutritional facet of inflammatory prognostication in acute aortic dissection","volume":"37","author":"Magoon","year":"2022","journal-title":"J Card Surg"},{"issue":"28","key":"10.1016\/j.ijcha.2024.101530_b0060","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.2174\/1381612827666210210142200","article-title":"Thoracic Aortic Aneurysm: Blood Pressure and Inflammation as Key Factors in the Development of Aneurysm Dissection","volume":"27","author":"Postnov","year":"2021","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0065","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10753-022-01626-z","article-title":"Aortic Wall Inflammation in the Pathogenesis, Diagnosis and Treatment of Aortic Aneurysms","volume":"45","author":"Skotsimara","year":"2022","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.ijcha.2024.101530_b0070","doi-asserted-by":"crossref","first-page":"E829","DOI":"10.1532\/hsf.5025","article-title":"Effect of Dexmedetomidine on Inflammatory Response in Aortic Dissection","volume":"25","author":"Gao","year":"2022","journal-title":"Heart Surg Forum"},{"issue":"1","key":"10.1016\/j.ijcha.2024.101530_b0075","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1038\/s41467-022-32658-6","article-title":"Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling","volume":"13","author":"Adachi","year":"2022","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.ijcha.2024.101530_b0080","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s12012-020-09580-8","article-title":"Effects of Extracellular Matrix Softening on Vascular Smooth Muscle Cell Dysfunction","volume":"20","author":"Shao","year":"2020","journal-title":"Cardiovasc Toxicol"},{"issue":"20","key":"10.1016\/j.ijcha.2024.101530_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells11203218","article-title":"Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijcha.2024.101530_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.675647","article-title":"Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells","volume":"8","author":"Qiu","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.ijcha.2024.101530_b0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","article-title":"The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy","volume":"12","author":"Oduro","year":"2022","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"10.1016\/j.ijcha.2024.101530_b0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13019-022-01901-y","article-title":"Metabolic syndrome and its components are associated with hypoxemia after surgery for acute type A aortic dissection: an observational study","volume":"17","author":"Zhang","year":"2022","journal-title":"J Cardiothorac Surg"},{"issue":"19","key":"10.1016\/j.ijcha.2024.101530_b0105","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian Randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.ijcha.2024.101530_b0110","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ijcha.2024.101530_b0115","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"Bmj"},{"issue":"8","key":"10.1016\/j.ijcha.2024.101530_b0120","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ijcha.2024.101530_b0130","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1177\/0962280215597579","article-title":"A review of instrumental variable estimators for Mendelian randomization","volume":"26","author":"Burgess","year":"2017","journal-title":"Stat Methods Med Res"},{"issue":"10","key":"10.1016\/j.ijcha.2024.101530_b0135","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ijcha.2024.101530_b0140","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41588-022-01270-1","article-title":"Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases","volume":"55","author":"Chen","year":"2023","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.ijcha.2024.101530_b0145","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/ije\/dyz173","article-title":"Cohort Profile: The Canadian Longitudinal Study on Aging (CLSA)","volume":"48","author":"Raina","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0150","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.ijcha.2024.101530_b0155","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/ije\/dyu176","article-title":"Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways","volume":"44","author":"Burgess","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ijcha.2024.101530_b0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.ijcha.2024.101530_b0165","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41588-018-0164-2","article-title":"Publisher Correction: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ijcha.2024.101530_b0170","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10654-017-0276-5","article-title":"Erratum to: Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"issue":"7121","key":"10.1016\/j.ijcha.2024.101530_b0175","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","article-title":"Meta-analysis: principles and procedures","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj"},{"issue":"8","key":"10.1016\/j.ijcha.2024.101530_b0180","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/CIRCULATIONAHA.116.020838","article-title":"Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans","volume":"134","author":"van der Valk","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2024.101530_b0185","doi-asserted-by":"crossref","first-page":"9782594","DOI":"10.1155\/2019\/9782594","article-title":"Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences","volume":"2019","author":"Cifani","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.ijcha.2024.101530_b0190","doi-asserted-by":"crossref","first-page":"1087978","DOI":"10.3389\/fimmu.2023.1087978","article-title":"Analysis of immunogenic cell death in ascending thoracic aortic aneurysms based on single-cell sequencing data","volume":"14","author":"Tian","year":"2023","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0195","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jtcvs.2005.09.018","article-title":"Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections","volume":"131","author":"He","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ijcha.2024.101530_b0200","article-title":"Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.ijcha.2024.101530_b0205","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10238-019-00570-x","article-title":"Lag3(+) regulatory T lymphocytes in critical carotid artery stenosis","volume":"19","author":"Del Porto","year":"2019","journal-title":"Clin Exp Med"},{"issue":"6","key":"10.1016\/j.ijcha.2024.101530_b0210","doi-asserted-by":"crossref","first-page":"e24469","DOI":"10.1002\/jcla.24469","article-title":"Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C-reactive protein, D-dimer, and mortality risk in Stanford type A aortic dissection patients","volume":"36","author":"Song","year":"2022","journal-title":"J Clin Lab Anal"},{"issue":"3","key":"10.1016\/j.ijcha.2024.101530_b0215","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ejvs.2018.07.004","article-title":"Identification of Lysophosphatidylcholines and Sphingolipids as Potential Biomarkers for Acute Aortic Dissection via Serum Metabolomics","volume":"57","author":"Zhou","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ijcha.2024.101530_b0220","doi-asserted-by":"crossref","first-page":"1019598","DOI":"10.3389\/fcvm.2022.1019598","article-title":"Potential metabolomic biomarkers for the identification and diagnosis of type A acute aortic dissection in patients with hypertension","volume":"9","author":"Hao","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"10.1016\/j.ijcha.2024.101530_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081850","article-title":"Emerging Roles of Gut Microbial Modulation of Bile Acid Composition in the Etiology of Cardiovascular Diseases","volume":"15","author":"Yntema","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ijcha.2024.101530_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109351","article-title":"Ketamine, benzoate, and sarcosine for treating depression","volume":"223","author":"Cheng","year":"2023","journal-title":"Neuropharmacology"},{"issue":"21","key":"10.1016\/j.ijcha.2024.101530_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115908","article-title":"Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906724001969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906724001969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T05:01:24Z","timestamp":1751259684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906724001969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":47,"alternative-id":["S2352906724001969"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2024.101530","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting causal relationships between immune cells, blood metabolites, and aortic dissection: A mediation Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2024.101530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101530"}}