{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T14:05:13Z","timestamp":1750255513053,"version":"3.38.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010738","name":"Stavanger University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ijcha.2025.101600","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:36:54Z","timestamp":1736771814000},"page":"101600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin"],"prefix":"10.1016","volume":"56","author":[{"given":"Dennis Winston T.","family":"Nilsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reidun","family":"Aarsetoey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Poenitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika Elisabet","family":"Michelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trygve","family":"Brugger-Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Staines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Grundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ijcha.2025.101600_b0005","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.CIR.83.2.484","article-title":"In-hospital and 1-year mortality in 1,524 women after myocardial infarction. Comparison with 4,315 men","volume":"83","author":"Greenland","year":"1991","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcha.2025.101600_b0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJM199801013380102","article-title":"A comparison of the early outcome of acute myocardial infarction in women and men, The Third International Study of Infarct Survival Collaborative Group","volume":"338","author":"Malacrida","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101600_b0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJM199907223410401","article-title":"Sex-based differences in early mortality after myocardial infarction","volume":"341","author":"Vaccarino","year":"1999","journal-title":"New England J. Med."},{"key":"10.1016\/j.ijcha.2025.101600_b0020","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/eurheartj\/ehi719","article-title":"on behalf of the USIC Investigators. Impact of age and gender on in-hospital and late mortality after acute myocardial infarction: increased early risk in younger women. Results from the French nation-wide USIC registries","volume":"27","author":"Simon","year":"2006","journal-title":"EHJ."},{"key":"10.1016\/j.ijcha.2025.101600_b0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/clc.21966","article-title":"Myocardial ischemia in women: lessons from the NHLBI WISE Study","volume":"35","author":"Gulati","year":"2012","journal-title":"Clin. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101600_b0030","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015634","article-title":"State of the science in women\u2019s cardiovascular disease: a Canadian perspective on the influence of sex and gender","volume":"9","author":"Norris","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101600_b0035","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/CIRCRESAHA.121.319895","article-title":"Pregnancy and reproductive risk factors for cardiovascular disease in women","volume":"130","author":"O\u2019Kelly","year":"2022","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.ijcha.2025.101600_b0040","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/jech-2016-207890","article-title":"Sex differences in the relationship between socioeconomic status and cardiovascular disease: a systematic review and meta-analysis","volume":"71","author":"Backholder","year":"2017","journal-title":"J. Epidemiol. Community Health"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101600_b0045","article-title":"Gender differences in cardiovascular disease","volume":"4","author":"Gao","year":"2019","journal-title":"Med. Nov. Technol. Devices."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101600_b0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1586\/17474086.1.1.3","article-title":"Sex differences in thrombosis","volume":"1","author":"Nordstrom","year":"2008","journal-title":"Expert. Rev. Haematol."},{"key":"10.1016\/j.ijcha.2025.101600_b0055","article-title":"Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases","volume":"364","author":"Vinogradova","year":"2019","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.ijcha.2025.101600_b0060","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/CIRCRESAHA.121.319916","article-title":"Sexual dimorphism in cardiovascular biomarkers: clinical and research implications","volume":"130","author":"Lau","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcha.2025.101600_b0065","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.ijcha.2025.101600_b0070","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101600_b0075","first-page":"C106","article-title":"An integrative view of serpins in health and disease: the contribution of SerpinA3","volume":"320","author":"S\u00e1nchez-Navarro","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101600_b0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000537919","article-title":"\u03b11-Antichymotrypsin complex (SERPINA3) is an independent predictor of all-cause but not cardiovascular mortality in patients hospitalized for chest pain of suspected coronary origin","volume":"149","author":"Nilsen","year":"2024","journal-title":"Cardiology"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101600_b0085","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.atherosclerosis.2009.09.030","article-title":"The associations of interleukin-6 and downstream inflammatory markers with risk of cardiovascular disease: the Caerphilly Study","volume":"209","author":"Patterson","year":"2010","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.ijcha.2025.101600_b0090","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1177\/2047487315619733","article-title":"Long-term prognostic utility of pentraxin 3 and D-dimer as compared to high-sensitivity C-reactive protein and B-type natriuretic peptide in suspected acute coronary syndrome","volume":"23","author":"Mjelva","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101600_b0095","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1161\/01.CIR.0000145167.30987.2E","article-title":"L, et al, Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction","volume":"110","author":"Latini","year":"2004","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ijcha.2025.101600_b0100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/MBC.0b013e32830b1512","article-title":"The prognostic utility of D-dimer and fibrin monomer at long-term follow-up after hospitalization with coronary chest pain","volume":"19","author":"Br\u00fcgger-Andersen","year":"2008","journal-title":"Blood Coagulation Fibrinol."},{"key":"10.1016\/j.ijcha.2025.101600_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.608899","article-title":"Alpha2-antiplasmin: the devil you don't know in cerebrovascular and cardiovascular Disease","volume":"7","author":"Singh","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"7","key":"10.1016\/j.ijcha.2025.101600_b0110","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/clinchem\/44.7.1430","article-title":"Cardiac troponin T by Elecsys system and a rapid ELISA: analytical sensitivity in relation to the TropT (CardiacT) \u201cbedside\u201d test","volume":"44","author":"Hetland","year":"1998","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/j.ijcha.2025.101600_b0115","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3109\/00365519509075400","article-title":"Cardiac troponin T immunoassay on biotinstreptavidin-coated microplates: preliminary performance in acute myocardial infarction","volume":"55","author":"Hetland","year":"1995","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.ijcha.2025.101600_b0120","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/eurheartj\/ehi052","article-title":"Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study","volume":"26","author":"Yarnell","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcha.2025.101600_b0125","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/CIRCULATIONAHA.106.635169","article-title":"Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrin, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population","volume":"115","author":"Rudnicka","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcha.2025.101600_b0130","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.thromres.2013.09.033","article-title":"Age- and sex-dependent reference intervals for D-dimer: evidence for a marked increase by age","volume":"132","author":"Haase","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijcha.2025.101600_b0135","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11739-011-0608-5","article-title":"Age and gender specific cut-off values improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrence","volume":"8","author":"Legnani","year":"2013","journal-title":"Intern. Emerg. Med."},{"issue":"8","key":"10.1016\/j.ijcha.2025.101600_b0140","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/acem.14220","article-title":"Sex-related differences in D-dimer levels for venous thromboembolism screening","volume":"28","author":"Raegh","year":"2021","journal-title":"Acad. Emerg. Med."},{"issue":"3","key":"10.1016\/j.ijcha.2025.101600_b0145","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jacc.2005.04.051","article-title":"Race and gender differences in C-reactive protein levels","volume":"46","author":"Khera","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcha.2025.101600_b0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ahj.2006.02.015","article-title":"Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort","volume":"152","author":"Lakoski","year":"2006","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101600_b0155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/biomedicines11010156","article-title":"SERPINA3: Stimulator or inhibitor of pathological changes","volume":"11","author":"de Mezer","year":"2023","journal-title":"Biomedicines."},{"issue":"8","key":"10.1016\/j.ijcha.2025.101600_b0160","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cvr\/cvae075","article-title":"Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction","volume":"120","author":"Sun","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcha.2025.101600_b0165","article-title":"PTX3 intercepts vascular inflammation in systemic immune-mediated diseases","volume":"10","author":"Ramirez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijcha.2025.101600_b0170","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCULATIONAHA.117.029901","article-title":"D-dimer predicts long-term cause-specific mortality, cardiovascular events, and cancer in patients with stable coronary heart disease","volume":"138","author":"Simes","year":"2018","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ijcha.2025.101600_b0175","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3324\/haematol.2012.083410","article-title":"Moli-Sani Project Investigators, Association of D-dimer levels with all-cause mortality in a healthy adult population: findings from the MOLI-SANI study","volume":"98","author":"Di Castelnuovo","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.ijcha.2025.101600_b0180","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1538-7836.2007.02528.x","article-title":"Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular health Study","volume":"5","author":"Zakai","year":"2007","journal-title":"J. Thromb. Haemostas."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672500003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672500003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T15:32:29Z","timestamp":1740756749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235290672500003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":36,"alternative-id":["S235290672500003X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101600","relation":{},"ISSN":["2352-9067"],"issn-type":[{"type":"print","value":"2352-9067"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101600"}}