{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:03:54Z","timestamp":1787965434648,"version":"build-2784847793"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijcha.2025.101720","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T11:10:52Z","timestamp":1750072252000},"page":"101720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome"],"prefix":"10.1016","volume":"59","author":[{"given":"Valeria","family":"Pergola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-7263","authenticated-orcid":false,"given":"Dan-Alexandru","family":"Cozac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Savo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pedrinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Perrone-Filardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morena De","family":"Amicis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vittoria","family":"Chiaruttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Cordoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Lorenzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Gerosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio De","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Corrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pontone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.ijcha.2025.101720_b0005","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.jacc.2015.08.872","article-title":"Mitral annulus calcification","volume":"66","author":"Abramowitz","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101720_b0010","doi-asserted-by":"crossref","unstructured":"Elmariah S, Budoff MJ, Delaney JA, Hamirani Y, Eng J, Fuster V, Kronmal RA, Halperin JL, O'Brien KD. Risk factors associated with the incidence and progression of mitral annulus calcification: the multi-ethnic study of atherosclerosis. Am Heart J. 2013 Nov;166(5):904-12. doi: 10.1016\/j.ahj.2013.08.015. Epub 2013 Sep 26. PMID: 24176447; PMCID: PMC3978772.","DOI":"10.1016\/j.ahj.2013.08.015"},{"key":"10.1016\/j.ijcha.2025.101720_b0015","doi-asserted-by":"crossref","unstructured":"Kanjanauthai S, Nasir K, Katz R, Rivera JJ, Takasu J, Blumenthal RS, Eng J, Budoff MJ. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2010 Dec;213(2):558-62. doi: 10.1016\/j.atherosclerosis.2010.08.072. Epub 2010 Sep 16. PMID: 20926076; PMCID: PMC2997868.","DOI":"10.1016\/j.atherosclerosis.2010.08.072"},{"issue":"1","key":"10.1016\/j.ijcha.2025.101720_b0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ahj.2005.03.052","article-title":"Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. the Cardiovascular Health Study (CHS)","volume":"151","author":"Barasch","year":"2006","journal-title":"Am. Heart J."},{"issue":"2","key":"10.1016\/j.ijcha.2025.101720_b0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/jcecho.jcecho_20_24","article-title":"Caseous calcification of the mitral annulus associated with severe mitral regurgitation: a multimodality diagnostic approach","volume":"34","author":"Cozac","year":"2024","journal-title":"Journal of Cardiovascular Echography"},{"issue":"16","key":"10.1016\/j.ijcha.2025.101720_b0030","first-page":"1194","article-title":"Concomitant mitral annular calcification and severe aortic stenosis: prevalence, characteristics and outcome following transcatheter aortic valve replacement","volume":"38","author":"Abramowitz","year":"2017","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.ijcha.2025.101720_b0035","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3390\/jcm13030896","article-title":"Mitral annular calcification-related valvular disease: a challenging entity","volume":"13","author":"Museedi","year":"2024","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.ijcha.2025.101720_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269475","article-title":"Potential role of conventional and speckle-tracking echocardiography in the screening of structural and functional cardiac abnormalities in elderly individuals: Baseline echocardiographic findings from the LOOP study","volume":"17","author":"Olsen","year":"2022","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101720_b0045","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.008513","article-title":"Disease activity in mitral annular calcification","volume":"12","author":"Massera","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"9","key":"10.1016\/j.ijcha.2025.101720_b0050","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jcmg.2020.03.013","article-title":"A cardiac computed tomography-based score to categorize mitral annular calcification severity and predict valve embolization","volume":"13","author":"Guerrero","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"201","key":"10.1016\/j.ijcha.2025.101720_b0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.amjcard.2023.05.069","article-title":"A systematic review and meta-analysis of prevalence, characteristics, and impact of mitral annular calcification on outcomes after transcatheter aortic valve implantation","volume":"15","author":"Moin","year":"2023","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101720_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcct.2018.11.008","article-title":"Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI) \/ transcatheter aortic valve replacement (TAVR): an expert consensus document of the society of cardiovascular computed tomography","author":"Blanke","year":"2019","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"issue":"6","key":"10.1016\/j.ijcha.2025.101720_b0065","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/diagnostics12061446","article-title":"Added value of CCTA-derived features to predict MACEs in stable patients undergoing coronary computed tomography","volume":"12","author":"Pergola","year":"2022","journal-title":"Diagnostics (basel)."},{"key":"10.1016\/j.ijcha.2025.101720_b0070","doi-asserted-by":"crossref","unstructured":"Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., & Executive Group on behalf of the Joint European Society of Cardiology (ESC)\/American College of Cardiology (ACC)\/American Heart Association (AHA)\/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction (2018). Fourth Universal Definition of Myocardial Infarction (2018).Journal of the American College of Cardiology,72(18), 2231\u20132264. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1038.","DOI":"10.1161\/CIR.0000000000000617"},{"key":"10.1016\/j.ijcha.2025.101720_b0075","doi-asserted-by":"crossref","unstructured":"Brignole, M., Moya, A., de Lange, F. J., Deharo, J. C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Mart\u00edn, A., Probst, V., Reed, M. J., Rice, C. P., Sutton, R., Ungar, A., van Dijk, J. G., & ESC Scientific Document Group (2018). 2018 ESC Guidelines for the diagnosis and management of syncope.European heart journal,39(21), 1883\u20131948. https:\/\/doi.org\/10.1093\/eurheartj\/ehy037.","DOI":"10.5603\/KP.2018.0161"},{"key":"10.1016\/j.ijcha.2025.101720_b0080","doi-asserted-by":"crossref","unstructured":"Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, J\u00fcni P, Pierard L, Prendergast BD, S\u00e1daba JR, Tribouilloy C, Wojakowski W; ESC\/EACTS Scientific Document Group. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022 Feb 12;43(7):561-632. doi: 10.1093\/eurheartj\/ehab395. Erratum in: Eur Heart J. 2022 Jun 1;43(21):2022. doi: 10.1093\/eurheartj\/ehac051. PMID: 34453165.","DOI":"10.1093\/eurheartj\/ehac051"},{"issue":"3","key":"10.1016\/j.ijcha.2025.101720_b0085","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcin.2023.12.005","article-title":"National variability in pacemaker implantation rate following TAVR: insights from the STS\/ACC TVT registry","volume":"17","author":"Vora","year":"2024","journal-title":"JACC Cardiovasc. Interv."},{"issue":"21","key":"10.1016\/j.ijcha.2025.101720_b0090","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.jcin.2023.07.007","article-title":"Outcomes of transcatheter aortic valve replacement in asymptomatic or minimally symptomatic aortic stenosis","volume":"16","author":"Huded","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"issue":"9986","key":"10.1016\/j.ijcha.2025.101720_b0095","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0140-6736(15)60290-2","article-title":"PARTNER trial investigators. 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial","volume":"385","author":"Kapadia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ijcha.2025.101720_b0100","doi-asserted-by":"crossref","unstructured":"Makkar RR, Thourani VH, Mack MJ, Kodali SK, Kapadia S, Webb JG, Yoon SH, Trento A, Svensson LG, Herrmann HC, Szeto WY, Miller DC, Satler L, Cohen DJ, Dewey TM, Babaliaros V, Williams MR, Kereiakes DJ, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Brown DL, Fearon WF, Russo MJ, Pibarot P, Hahn RT, Jaber WA, Rogers E, Xu K, Wheeler J, Alu MC, Smith CR, Leon MB; PARTNER 2 Investigators. Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement. N Engl J Med. 2020 Jan 29;382(9):799-809. doi: 10.1056\/NEJMoa1910555. PMID: 31995682.","DOI":"10.1056\/NEJMoa1910555"},{"key":"10.1016\/j.ijcha.2025.101720_b0105","doi-asserted-by":"crossref","unstructured":"Pontone G, Rossi A, Guglielmo M, Dweck MR, Gaemperli O, Nieman K, Pugliese F, Maurovich-Horvat P, Gimelli A, Cosyns B, Achenbach S. Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part I. Eur Heart J Cardiovasc Imaging. 2022 Feb 22;23(3):299-314. doi: 10.1093\/ehjci\/jeab293. Erratum in: Eur Heart J Cardiovasc Imaging. 2022 Jun 1;23(6):e274. doi: 10.1093\/ehjci\/jeac047. PMID: 35076061; PMCID: PMC8863074.","DOI":"10.1093\/ehjci\/jeab293"},{"key":"10.1016\/j.ijcha.2025.101720_b0110","doi-asserted-by":"crossref","unstructured":"Abdelkhalek M, Bahadormanesh N, Ganame J, Keshavarz-Motamed Z. Incremental prognostic value of intensity-weighted regional calcification scoring using contrast CT imaging in TAVR. Eur Heart J Imaging Methods Pract. 2023 Sep 29;1(2):qyad027. doi: 10.1093\/ehjimp\/qyad027. PMID: 39045072; PMCID: PMC11195730.","DOI":"10.1093\/ehjimp\/qyad027"},{"issue":"3","key":"10.1016\/j.ijcha.2025.101720_b0115","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1756-0500-3-326","article-title":"Incidental cardiac findings on computed tomography imaging of the thorax","volume":"3","author":"Foley","year":"2010","journal-title":"BMC. Res. Notes"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101720_b0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00380-014-0585-5","article-title":"Mitral annular calcification in patients undergoing aortic valve replacement for aortic valve stenosis","volume":"31","author":"Takami","year":"2016","journal-title":"Heart Vessels"},{"issue":"12","key":"10.1016\/j.ijcha.2025.101720_b0125","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.amjcard.2017.09.006","article-title":"Impact of mitral annular calcium on outcomes after transcatheter aortic valve implantation","volume":"120","author":"Ancona","year":"2017","journal-title":"Am. J. Cardiol."},{"issue":"180","key":"10.1016\/j.ijcha.2025.101720_b0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.amjcard.2022.06.039","article-title":"Comparison of outcomes of transcatheter aortic valve implantation in patients with versus without mitral annular calcium","volume":"1","author":"Lak","year":"2022","journal-title":"Am. J. Cardiol."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672500123X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235290672500123X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:04:42Z","timestamp":1755619482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235290672500123X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":26,"alternative-id":["S235290672500123X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101720","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101720"}}