{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:31:19Z","timestamp":1782333079397,"version":"3.54.5"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijcha.2025.101830","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:38:28Z","timestamp":1761496708000},"page":"101830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Multidimensional optimization of stent design for endothelial shear stress regulation: Geometric structuring, surface functionalization strategies to mitigate thrombosis and restenosis"],"prefix":"10.1016","volume":"61","author":[{"given":"Mengyuan","family":"Che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuliu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingsen","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0005","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41419-024-07166-8","article-title":"Inflammation in atherosclerosis: pathophysiology and mechanisms","volume":"15","author":"Ajoolabady","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijcha.2025.101830_b0010","doi-asserted-by":"crossref","unstructured":"Tasouli-Drakou, V.; Ogurek, I.; Shaikh, T.; Ringor, M.; DiCaro, M. V.; Lei, K. Atherosclerosis: A Comprehensive Review of Molecular Factors and Mechanisms. Int J Mol Sci 2025, 26 (3). DOI: 10.3390\/ijms26031364 From NLM.","DOI":"10.3390\/ijms26031364"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0015","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5603\/CJ.a2020.0024","article-title":"Local fluid dynamics in patients with bifurcated coronary lesions undergoing percutaneous coronary interventions","volume":"28","author":"Genuardi","year":"2021","journal-title":"Cardiol. J."},{"key":"10.1016\/j.ijcha.2025.101830_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.117449","article-title":"Comprehensive biomechanical and anatomical atherosclerotic plaque metrics predict major adverse cardiovascular events: a new tool for clinical decision making","volume":"390","author":"Gu","year":"2024","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00047.2009","article-title":"Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives","volume":"91","author":"Chiu","year":"2011","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.ijcha.2025.101830_b0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.abb.2015.11.005","article-title":"The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches","volume":"591","author":"Simmons","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"23\u201324","key":"10.1016\/j.ijcha.2025.101830_b0040","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1089\/ten.tea.2023.0362","article-title":"Elevated Shear stress Modulates Heterogenous Cellular Subpopulations to Induce Vascular Remodeling","volume":"30","author":"Fischer","year":"2024","journal-title":"Tissue Eng. Part A"},{"issue":"10","key":"10.1016\/j.ijcha.2025.101830_b0045","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijcha.2025.101830_b0050","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2024.08.004","article-title":"Vascular endothelium: the interface for multiplex signal transduction","volume":"195","author":"Cheng","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0055","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41569-019-0239-5","article-title":"Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes","volume":"17","author":"Souilhol","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101830_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108152","article-title":"Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics","volume":"235","author":"He","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcha.2025.101830_b0065","doi-asserted-by":"crossref","unstructured":"Hauger, P. C.; Hordijk, P. L. Shear Stress-Induced AMP-Activated Protein Kinase Modulation in Endothelial Cells: Its Role in Metabolic Adaptions and Cardiovascular Disease. Int J Mol Sci 2024, 25 (11). DOI: 10.3390\/ijms25116047 From NLM.","DOI":"10.3390\/ijms25116047"},{"key":"10.1016\/j.ijcha.2025.101830_b0070","doi-asserted-by":"crossref","unstructured":"Tanaka, K.; Chen, M.; Prendergast, A.; Zhuang, Z.; Nasiri, A.; Joshi, D.; Hintzen, J.; Chung, M.; Kumar, A.; Mani, A.; et al. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. bioRxiv 2024. DOI: 10.1101\/2024.06.13.598386 From NLM.","DOI":"10.1101\/2024.06.13.598386"},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s12195-024-00805-2","article-title":"P300 Modulates Endothelial Mechanotransduction of Fluid Shear stress","volume":"17","author":"Whitworth","year":"2024","journal-title":"Cell. Mol. Bioeng."},{"issue":"19\u201320","key":"10.1016\/j.ijcha.2025.101830_b0080","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/scd.2024.0088","article-title":"An Endothelial Cell is not simply an Endothelial Cell","volume":"33","author":"Limbu","year":"2024","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ijcha.2025.101830_b0085","doi-asserted-by":"crossref","unstructured":"Wakasugi, R.; Suzuki, K.; Kaneko-Kawano, T. Molecular Mechanisms Regulating Vascular Endothelial Permeability. Int J Mol Sci 2024, 25 (12). DOI: 10.3390\/ijms25126415 From NLM.","DOI":"10.3390\/ijms25126415"},{"issue":"6","key":"10.1016\/j.ijcha.2025.101830_b0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.31083\/j.fbl2906223","article-title":"Endothelial Cell Dysfunction: Onset, Progression, and Consequences","volume":"29","author":"Naderi-Meshkin","year":"2024","journal-title":"Front Biosci (landmark Ed)"},{"key":"10.1016\/j.ijcha.2025.101830_b0095","doi-asserted-by":"crossref","unstructured":"Li, G.; Yang, Q.; Yang, Y.; Yang, G.; Wan, J.; Ma, Z.; Du, L.; Sun, Y.; Zhang, G. Laminar shear stress alters endothelial KCa2.3 expression in H9c2 cells partially via regulating the PI3K\/Akt\/p300 axis. Int J Mol Med 2019, 43 (3), 1289-1298. DOI: 10.3892\/ijmm.2019.4063 From NLM.","DOI":"10.3892\/ijmm.2019.4063"},{"key":"10.1016\/j.ijcha.2025.101830_b0100","doi-asserted-by":"crossref","unstructured":"Takai, J.; Santu, A.; Zheng, H.; Koh, S. D.; Ohta, M.; Filimban, L. M.; Lema\u00eetre, V.; Teraoka, R.; Jo, H.; Miura, H. Laminar shear stress upregulates endothelial Ca2+-activated K+ channels KCa2.3 and KCa3.1 via a Ca2+\/calmodulin-dependent protein kinase kinase\/Akt\/p300 cascade. Am J Physiol Heart Circ Physiol 2013, 305 (4), H484-493. DOI: 10.1152\/ajpheart.00642.2012 From NLM.","DOI":"10.1152\/ajpheart.00642.2012"},{"key":"10.1016\/j.ijcha.2025.101830_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1432719","article-title":"Low or oscillatory shear stress and endothelial permeability in atherosclerosis","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.ijcha.2025.101830_b0110","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/anae.12661","article-title":"The endothelial glycocalyx: a review of the vascular barrier","volume":"69","author":"Alphonsus","year":"2014","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10237-013-0502-3","article-title":"Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro","volume":"13","author":"Bai","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.ijcha.2025.101830_b0120","doi-asserted-by":"crossref","unstructured":"Abdelilah-Seyfried, S.; Ola, R. Shear stress and pathophysiological PI3K involvement in vascular malformations. J Clin Invest 2024, 134 (10). DOI: 10.1172\/jci172843 From NLM.","DOI":"10.1172\/JCI172843"},{"key":"10.1016\/j.ijcha.2025.101830_b0125","doi-asserted-by":"crossref","unstructured":"Deng, H.; Min, E.; Baeyens, N.; Coon, B. G.; Hu, R.; Zhuang, Z. W.; Chen, M.; Huang, B.; Afolabi, T.; Zarkada, G.; et al. Activation of Smad2\/3 signaling by low fluid shear stress mediates artery inward remodeling. Proc Natl Acad Sci U S A 2021, 118 (37). DOI: 10.1073\/pnas.2105339118 From NLM.","DOI":"10.1073\/pnas.2105339118"},{"issue":"25","key":"10.1016\/j.ijcha.2025.101830_b0130","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jacc.2007.02.059","article-title":"Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior","volume":"49","author":"Chatzizisis","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101830_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106609","article-title":"How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative residence time","volume":"154","author":"Mutlu","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.ijcha.2025.101830_b0140","article-title":"Multiscale Modeling of Vascular Remodeling Induced by Wall Shear stress","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Physiol."},{"issue":"15","key":"10.1016\/j.ijcha.2025.101830_b0145","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jacc.2011.10.903","article-title":"Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation","volume":"59","author":"Koskinas","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0150","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jacbts.2024.07.008","article-title":"Endothelial Shear stress Metrics associate with Proinflammatory Pathways at the Culprit Site of Coronary erosion","volume":"9","author":"Ahmed","year":"2024","journal-title":"JACC Basic Transl Sci"},{"issue":"8","key":"10.1016\/j.ijcha.2025.101830_b0155","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s10439-009-9719-9","article-title":"Hemodynamically driven stent strut design","volume":"37","author":"Jim\u00e9nez","year":"2009","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.ijcha.2025.101830_b0160","doi-asserted-by":"crossref","unstructured":"LaDisa, J. F., Jr.; Olson, L. E.; Guler, I.; Hettrick, D. A.; Audi, S. H.; Kersten, J. R.; Warltier, D. C.; Pagel, P. S. Stent design properties and deployment ratio influence indexes of wall shear stress: a three-dimensional computational fluid dynamics investigation within a normal artery. J Appl Physiol (1985) 2004, 97 (1), 424-430; discussion 416. DOI: 10.1152\/japplphysiol.01329.2003 From NLM.","DOI":"10.1152\/japplphysiol.01329.2003"},{"key":"10.1016\/j.ijcha.2025.101830_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1067566","article-title":"Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: a simulation study with computational fluid dynamics modeling","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Neurol."},{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0170","doi-asserted-by":"crossref","first-page":"e930","DOI":"10.4244\/EIJ-D-19-00657","article-title":"Impact of bioresorbable scaffold design characteristics on local haemodynamic forces: an ex vivo assessment with computational fluid dynamics simulations","volume":"16","author":"Tarrahi","year":"2020","journal-title":"EuroIntervention"},{"issue":"4","key":"10.1016\/j.ijcha.2025.101830_b0175","doi-asserted-by":"crossref","first-page":"H989","DOI":"10.1152\/ajpheart.00431.2024","article-title":"Integrating molecular and cellular components of endothelial shear stress mechanotransduction","volume":"327","author":"Power","year":"2024","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.ijcha.2025.101830_b0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow-mediated endothelial mechanotransduction","volume":"75","author":"Davies","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcha.2025.101830_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105412","article-title":"Force-sensing protein expression in response to cardiovascular mechanotransduction","volume":"110","author":"Wang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ijcha.2025.101830_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1446452","article-title":"Mechanosensory entities and functionality of endothelial cells","volume":"12","author":"Mierke","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ijcha.2025.101830_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102544","article-title":"Synthetic ion channels in biomembranes","volume":"84","author":"Kohata","year":"2025","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"26","key":"10.1016\/j.ijcha.2025.101830_b0200","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1021\/acs.nanolett.4c01371","article-title":"Dynamic Regulation of Cell Mechanotransduction through Sequentially Controlled Mobile Surfaces","volume":"24","author":"Xie","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.ijcha.2025.101830_b0205","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015059","article-title":"Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress","volume":"296","author":"Swain","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcha.2025.101830_b0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.actbio.2024.02.043","article-title":"Shear stress activates the Piezo1 channel to facilitate valvular endothelium-oriented differentiation and maturation of human induced pluripotent stem cells","volume":"178","author":"Xie","year":"2024","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.ijcha.2025.101830_b0215","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/s41416-024-02861-x","article-title":"Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits","volume":"131","author":"Liu","year":"2024","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0220","doi-asserted-by":"crossref","first-page":"H22","DOI":"10.1152\/ajpheart.2001.281.1.H22","article-title":"Mechanism of temporal gradients in shear-induced ERK1\/2 activation and proliferation in endothelial cells","volume":"281","author":"Bao","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcha.2025.101830_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104613","article-title":"Platelet and endothelial cell responses under concurrent shear stress and tensile strain","volume":"151","author":"Steadman","year":"2024","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0230","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41467-017-00230-2","article-title":"Flow-induced elongation of von Willebrand factor precedes tension-dependent activation","volume":"8","author":"Fu","year":"2017","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.ijcha.2025.101830_b0235","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/01.CIR.0000039327.11661.16","article-title":"Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke","volume":"106","author":"Cai","year":"2002","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.ijcha.2025.101830_b0240","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.282.21.2035","article-title":"Hemodynamic shear stress and its role in atherosclerosis","volume":"282","author":"Malek","year":"1999","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/cvr\/cvs217","article-title":"Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions","volume":"96","author":"Wentzel","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0250","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk","volume":"48","author":"Joner","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0255","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00059-016-4487-4","article-title":"Impact of stent implantation on endothelial shear stress","volume":"42","author":"Economou","year":"2017","journal-title":"Herz"},{"key":"10.1016\/j.ijcha.2025.101830_b0260","doi-asserted-by":"crossref","unstructured":"Shishido, K.; Antoniadis, A. P.; Takahashi, S.; Tsuda, M.; Mizuno, S.; Andreou, I.; Papafaklis, M. I.; Coskun, A. U.; O'Brien, C.; Feldman, C. L.; et al. Effects of Low Endothelial Shear Stress After Stent Implantation on Subsequent Neointimal Hyperplasia and Clinical Outcomes in Humans. J Am Heart Assoc 2016, 5 (9). DOI: 10.1161\/jaha.115.002949 From NLM.","DOI":"10.1161\/JAHA.115.002949"},{"issue":"15","key":"10.1016\/j.ijcha.2025.101830_b0265","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/eurheartj\/ehw006","article-title":"Malapposition: is it a major cause of stent thrombosis?","volume":"37","author":"Mori","year":"2016","journal-title":"Eur. Heart J."},{"issue":"18","key":"10.1016\/j.ijcha.2025.101830_b0270","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.106.658237","article-title":"Incomplete stent apposition and very late stent thrombosis after drug-eluting stent implantation","volume":"115","author":"Cook","year":"2007","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0275","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/eurheartj\/ehr484","article-title":"Impact of incomplete stent apposition on long-term clinical outcome after drug-eluting stent implantation","volume":"33","author":"Cook","year":"2012","journal-title":"Eur. Heart J."},{"issue":"47","key":"10.1016\/j.ijcha.2025.101830_b0280","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1093\/eurheartj\/ehv511","article-title":"Stent thrombosis and restenosis: what have we learned and where are we going? the Andreas Gr\u00fcntzig Lecture ESC 2014","volume":"36","author":"Byrne","year":"2015","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0285","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/13\/1\/016001","article-title":"Computational simulation of platelet interactions in the initiation of stent thrombosis due to stent malapposition","volume":"13","author":"Chesnutt","year":"2016","journal-title":"Phys. Biol."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101830_b0290","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s10439-017-1806-8","article-title":"Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling","volume":"45","author":"Karanasiou","year":"2017","journal-title":"Ann. Biomed. Eng."},{"issue":"12","key":"10.1016\/j.ijcha.2025.101830_b0295","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.jbiomech.2014.07.030","article-title":"Numerical investigations of the haemodynamic changes associated with stent malapposition in an idealised coronary artery","volume":"47","author":"Poon","year":"2014","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0300","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10439-015-1387-3","article-title":"Hemodynamics in Idealized Stented Coronary arteries: Important Stent Design Considerations","volume":"44","author":"Beier","year":"2016","journal-title":"Ann. Biomed. Eng."},{"issue":"13","key":"10.1016\/j.ijcha.2025.101830_b0305","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/CIRCULATIONAHA.110.003210","article-title":"Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings","volume":"123","author":"Kolandaivelu","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ijcha.2025.101830_b0310","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10554-018-1481-3","article-title":"Post-implantation shear stress assessment: an emerging tool for differentiation of bioresorbable scaffolds","volume":"35","author":"Tenekecioglu","year":"2019","journal-title":"Int. J. Cardiovasc. Imaging"},{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0315","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s10554-017-1173-4","article-title":"The effect of strut thickness on shear stress distribution in a preclinical model","volume":"33","author":"Tenekecioglu","year":"2017","journal-title":"Int. J. Cardiovasc. Imaging"},{"issue":"10","key":"10.1016\/j.ijcha.2025.101830_b0320","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0021-9290(00)00066-X","article-title":"Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution","volume":"33","author":"Wentzel","year":"2000","journal-title":"J. Biomech."},{"key":"10.1016\/j.ijcha.2025.101830_b0325","doi-asserted-by":"crossref","unstructured":"Banerjee, R. K.; Devarakonda, S. B.; Rajamohan, D.; Back, L. H. Developed pulsatile flow in a deployed coronary stent. Biorheology 2007, 44 (2), 91-102. From NLM.","DOI":"10.1177\/0006355X2007044002002"},{"issue":"8","key":"10.1016\/j.ijcha.2025.101830_b0330","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1525-1594.2007.00431.x","article-title":"A novel design of a noncylindric stent with beneficial effects on flow characteristics: an experimental and numerical flow study in an axisymmetric arterial model with sequential mild stenoses","volume":"31","author":"Papaioannou","year":"2007","journal-title":"Artif. Organs"},{"issue":"8","key":"10.1016\/j.ijcha.2025.101830_b0335","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1114\/1.1588654","article-title":"Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation","volume":"31","author":"LaDisa","year":"2003","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101830_b0340","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s10439-005-2499-y","article-title":"Computational study of fluid mechanical disturbance induced by endovascular stents","volume":"33","author":"Seo","year":"2005","journal-title":"Ann. Biomed. Eng."},{"issue":"181","key":"10.1016\/j.ijcha.2025.101830_b0345","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2021.0023","article-title":"Stent strut streamlining and thickness reduction promote endothelialization","volume":"18","author":"Nguyen","year":"2021","journal-title":"J. R. Soc. Interface"},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0350","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jjcc.2017.10.011","article-title":"Impact of everolimus-eluting stent length on long-term clinical outcomes of percutaneous coronary intervention","volume":"71","author":"Yano","year":"2018","journal-title":"J. Cardiol."},{"issue":"11","key":"10.1016\/j.ijcha.2025.101830_b0355","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.amjcard.2003.08.017","article-title":"Usefulness of shear stress pattern in predicting neointima distribution in sirolimus-eluting stents in coronary arteries","volume":"92","author":"Gijsen","year":"2003","journal-title":"Am. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101830_b0360","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1115\/1.1934122","article-title":"Blood flow in stented arteries: a parametric comparison of strut design patterns in three dimensions","volume":"127","author":"He","year":"2005","journal-title":"J. Biomech. Eng."},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0365","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0021-9290(02)00446-3","article-title":"Shear stress, vascular remodeling and neointimal formation","volume":"36","author":"Wentzel","year":"2003","journal-title":"J. Biomech."},{"issue":"188","key":"10.1016\/j.ijcha.2025.101830_b0370","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2021.0871","article-title":"A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics","volume":"19","author":"Corti","year":"2022","journal-title":"J. R. Soc. Interface"},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0375","first-page":"858","article-title":"Structural design and biomechanical numerical analysis of body-fitted stent in stenotic vessels","volume":"38","author":"Liu","year":"2021","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"issue":"12","key":"10.1016\/j.ijcha.2025.101830_b0380","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jacc.2011.09.079","article-title":"Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation","volume":"59","author":"Tearney","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcha.2025.101830_b0385","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jacc.2011.12.017","article-title":"The clinical emergence of optical coherence tomography: defining a role in intravascular imaging","volume":"59","author":"Tsimikas","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.ijcha.2025.101830_b0390","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s10439-012-0681-6","article-title":"Modeling stented coronary arteries: where we are, where to go","volume":"41","author":"Morlacchi","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"12","key":"10.1016\/j.ijcha.2025.101830_b0395","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1039\/D3BM00390F","article-title":"Restoring endothelial function: shedding light on cardiovascular stent development","volume":"11","author":"Liu","year":"2023","journal-title":"Biomater. Sci."},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0400","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/0003319713483543","article-title":"Association of remodeling with endothelial shear stress, plaque elasticity, and volume in coronary arteries: a pilot coronary computed tomography angiography study","volume":"65","author":"Katranas","year":"2014","journal-title":"Angiology"},{"key":"10.1016\/j.ijcha.2025.101830_b0405","doi-asserted-by":"crossref","unstructured":"Toledo, J. P.; Mart\u00ednez-Castillo, J.; Cardenas, D.; Delgado-Alvarado, E.; Vigueras-Zu\u00f1iga, M. O.; Herrera-May, A. L. Simplified Models to Assess the Mechanical Performance Parameters of Stents. Bioengineering (Basel) 2024, 11 (6). DOI: 10.3390\/bioengineering11060583 From NLM.","DOI":"10.3390\/bioengineering11060583"},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0410","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12265-017-9777-6","article-title":"Patient-specific Modeling of Stented Coronary arteries Reconstructed from Optical Coherence Tomography: Towards a Widespread Clinical use of Fluid Dynamics analyses","volume":"11","author":"Chiastra","year":"2018","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"20","key":"10.1016\/j.ijcha.2025.101830_b0415","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1039\/D2TB00478J","article-title":"Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia","volume":"10","author":"Feng","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"18","key":"10.1016\/j.ijcha.2025.101830_b0420","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","article-title":"Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization","volume":"115","author":"Finn","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2025.101830_b0425","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2014.12.003","article-title":"Endothelialization of drug eluting stents and its impact on dual anti-platelet therapy duration","volume":"93","author":"Habib","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.ijcha.2025.101830_b0430","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1021\/acsnano.6b04912","article-title":"Magnetic Nanoparticle-Mediated Targeting of Cell Therapy Reduces In-Stent Stenosis in Injured arteries","volume":"10","author":"Polyak","year":"2016","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.ijcha.2025.101830_b0435","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/cvr\/cvw210","article-title":"Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase","volume":"112","author":"Hsiao","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcha.2025.101830_b0440","doi-asserted-by":"crossref","DOI":"10.3389\/fmedt.2023.1149594","article-title":"Migration of endothelial cells on the surface of anodized Ni-Ti stent strut","volume":"5","author":"Wang","year":"2023","journal-title":"Front. Med. Technol."},{"key":"10.1016\/j.ijcha.2025.101830_b0445","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jmbbm.2018.09.003","article-title":"Braided bioresorbable cardiovascular stents mechanically reinforced by axial runners","volume":"89","author":"Zhao","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.ijcha.2025.101830_b0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10255842.2025.2465343","article-title":"Design of fish-scale microstructured stents and their biomechanical effects on cerebral aneurysm","author":"Fan","year":"2025","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"key":"10.1016\/j.ijcha.2025.101830_b0455","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.actbio.2019.01.059","article-title":"Micropatterning of a 2-methacryloyloxyethyl phosphorylcholine polymer surface by hydrogenated amorphous carbon thin films for endothelialization and antithrombogenicity","volume":"87","author":"Bito","year":"2019","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.ijcha.2025.101830_b0460","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1021\/acsabm.8b00833","article-title":"Microgrooves encourage Endothelial Cell Adhesion and Organization on Shape-memory Polymer Surfaces","volume":"2","author":"Govindarajan","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"issue":"18","key":"10.1016\/j.ijcha.2025.101830_b0465","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202000920","article-title":"Surface Engineering of Cardiovascular Devices for improved Hemocompatibility and Rapid Endothelialization","volume":"9","author":"Zhao","year":"2020","journal-title":"Adv. Healthc. Mater."},{"issue":"4","key":"10.1016\/j.ijcha.2025.101830_b0470","doi-asserted-by":"crossref","first-page":"e318","DOI":"10.4244\/EIJ-D-22-01058","article-title":"Clinical performance of a novel hybrid IVUS-OCT system: a multicentre, randomised, non-inferiority trial (PANOVISION)","volume":"19","author":"Jia","year":"2023","journal-title":"EuroIntervention"},{"issue":"1","key":"10.1016\/j.ijcha.2025.101830_b0475","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12880-019-0403-8","article-title":"Automated classification of dense calcium tissues in gray-scale intravascular ultrasound images using a deep belief network","volume":"19","author":"Lee","year":"2019","journal-title":"BMC Med. Imaging"},{"issue":"19","key":"10.1016\/j.ijcha.2025.101830_b0480","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.4244\/EIJ-D-23-00912","article-title":"Optical coherence tomography to guide percutaneous coronary intervention","volume":"20","author":"Almajid","year":"2024","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ijcha.2025.101830_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjcard.2025.08.023","article-title":"Ostial Stent Implantation or Crossover Stenting for Ostial LAD Lesions: the Multicenter CROSS-ANATOLIA Registry","author":"Tan\u0131k","year":"2025","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcha.2025.101830_b0490","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/fca-2019-0083","article-title":"The ultra-thin strut sirolimus-eluting coronary stent: SUPRAFLEX","volume":"17","author":"Gao","year":"2021","journal-title":"Future Cardiol."},{"key":"10.1016\/j.ijcha.2025.101830_b0495","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehaf418","article-title":"The Construction and Development of China's National Basic Science Center for Panvascular Interventional complex Systems: Pioneering Device-Vessel Suitcordance Research","author":"You","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcha.2025.101830_b0500","unstructured":"You, L.; Shen, L.; Ge, J. High\u2013Suitcordance Intelligent Fibers for Panvascular Disease Monitoring\u2013Intervention. Advanced Fiber Materials. DOI: \/10.1007\/s42765-025-00542-9."}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906725002337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906725002337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:41:52Z","timestamp":1764866512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906725002337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":100,"alternative-id":["S2352906725002337"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101830","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidimensional optimization of stent design for endothelial shear stress regulation: Geometric structuring, surface functionalization strategies to mitigate thrombosis and restenosis","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101830"}}