{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:06:59Z","timestamp":1779138419169,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008908","name":"University of Messina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijcha.2025.101842","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:41:10Z","timestamp":1762839670000},"page":"101842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effectiveness of cerebral embolic protection during transcatheter aortic valve replacement: A systematic review and meta-analysis of randomized trials"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-0818","authenticated-orcid":false,"given":"Rodolfo","family":"Caminiti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Vetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Parlavecchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Moscardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Laterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Tespili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Vizzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Micari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcha.2025.101842_b0005","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMoa2204961","article-title":"PROTECTED TAVR investigators, cerebral embolic protection during transcatheter aortic-valve replacement","volume":"387","author":"Kapadia","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2025.101842_b0010","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2415120","article-title":"BHF PROTECT-TAVI investigators, routine cerebral embolic protection during transcatheter aortic-valve implantation","author":"Kharbanda","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2025.101842_b0015","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcha.2025.101842_b0020","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1161\/CIRCULATIONAHA.112.110981","article-title":"Timing, predictive factors, and prognostic value of cerebrovascular events in a large cohort of patients undergoing transcatheter aortic valve implantation","author":"Nombela-Franco","year":"2012","journal-title":"Circulation 126"},{"key":"10.1016\/j.ijcha.2025.101842_b0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijcard.2016.06.143","article-title":"Silent cerebral injury after transcatheter aortic valve implantation and the preventive role of embolic protection devices: a systematic review and meta-analysis","volume":"221","author":"Pagnesi","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101842_b0030","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022329","article-title":"Silent cerebral infarction and cognitive function following TAVI: an observational two-centre UK comparison of the first-generation CoreValve and second-generation Lotus valve","volume":"9","author":"Musa","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.ijcha.2025.101842_b0035","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/eurheartj\/ehv191","article-title":"A prospective randomized evaluation of the TriGuardTM HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial","volume":"36","author":"Lansky","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcha.2025.101842_b0040","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038869","article-title":"Cerebral embolic protection devices in transcatheter aortic valve implantation: meta\u2010analysis with trial sequential analysis","volume":"14","author":"Warraich","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcha.2025.101842_b0045","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ijcha.2025.101842_b0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jacc.2016.11.045","article-title":"Proposed standardized neurological endpoints for cardiovascular clinical trials: an academic research consortium initiative","volume":"69","author":"Lansky","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101842_b0055","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1093\/ejcts\/ezs533","article-title":"Valve Academic Research Consortium (VARC)-2, Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2)","volume":"42","author":"Kappetein","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ijcha.2025.101842_b0060","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1093\/eurheartj\/ehab213","article-title":"A randomized evaluation of the TriGuardTM HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial","volume":"42","author":"Lansky","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcha.2025.101842_b0065","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.2016.10302","article-title":"Effect of a cerebral protection device on brain lesions following Transcatheter aortic valve implantation in patients with severe aortic stenosis: the CLEAN-TAVI randomized clinical trial","volume":"316","author":"Haussig","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ijcha.2025.101842_b0070","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jacc.2016.10.023","article-title":"Protection against cerebral embolism during transcatheter aortic valve replacement","volume":"69","author":"Kapadia","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101842_b0075","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4244\/EIJV12I4A84","article-title":"Filter-based cerebral embolic protection with transcatheter aortic valve implantation: the randomised MISTRAL-C trial","volume":"12","author":"Van Mieghem","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ijcha.2025.101842_b0080","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jcin.2020.11.011","article-title":"Randomized evaluation of TriGuard 3 cerebral embolic protection after transcatheter aortic valve replacement","volume":"14","author":"Nazif","year":"2021","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"10.1016\/j.ijcha.2025.101842_b0085","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amjcard.2024.08.014","article-title":"Long-term results following transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis: a systematic review and meta-analysis of randomized trials","volume":"230","author":"Caminiti","year":"2024","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcha.2025.101842_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcin.2023.11.011","article-title":"Technical aspects for transcatheter aortic valve replacement with the novel balloon-expandable myval octacor","author":"Ielasi","year":"2024","journal-title":"JACC Cardiovasc Interv 8;17(1):101\u2013103"},{"key":"10.1016\/j.ijcha.2025.101842_b0095","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/14779072.2024.2385989","article-title":"Cerebral embolic protection for stroke prevention during transcatheter aortic valve replacement","volume":"22","author":"Basit","year":"2024","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.ijcha.2025.101842_b0100","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.jcin.2018.03.001","article-title":"Debris Heterogeneity across different valve types captured by a cerebral protection system during transcatheter aortic valve replacement","volume":"11","author":"Schmidt","year":"2018","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"10.1016\/j.ijcha.2025.101842_b0105","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4244\/EIJ-D-20-00744","article-title":"Heterogeneity of debris captured by cerebral embolic protection filters during TAVI","volume":"16","author":"Kroon","year":"2021","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ijcha.2025.101842_b0110","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.jcin.2017.06.037","article-title":"Cerebral embolic protection during transcatheter aortic valve replacement significantly reduces death and stroke compared with unprotected procedures","volume":"10","author":"Seeger","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.ijcha.2025.101842_b0115","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/CIRCULATIONAHA.109.855866","article-title":"Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study","volume":"121","author":"Kahlert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcha.2025.101842_b0120","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jcin.2020.01.227","article-title":"Chimney stenting for coronary occlusion during TAVR: insights from the chimney registry","volume":"13","author":"Mercanti","year":"2020","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"10.1016\/j.ijcha.2025.101842_b0125","doi-asserted-by":"crossref","unstructured":"I. Komatsu, G. Mackensen, G.S. Aldea, M. Reisman, D. Dvir, Bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction. Part 2: how to perform BASILICA, (n.d.). DOI: 10.4244\/EIJ-D-19-00056.","DOI":"10.4244\/EIJ-D-19-00056"},{"key":"10.1016\/j.ijcha.2025.101842_b0130","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4244\/EIJ-D-23-00166","article-title":"Cerebral embolic protection during transcatheter heart interventions","volume":"19","author":"Jimenez Diaz","year":"2023","journal-title":"EuroIntervention"}],"updated-by":[{"DOI":"10.1016\/j.ijcha.2025.101843","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906725002453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906725002453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:39:48Z","timestamp":1764866388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906725002453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":26,"alternative-id":["S2352906725002453"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101842","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of cerebral embolic protection during transcatheter aortic valve replacement: A systematic review and meta-analysis of randomized trials","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2025.101842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101842"}}