{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:48:34Z","timestamp":1786654114869,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021018","name":"PharmaNutra SpA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart & Vasculature"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ijcha.2026.101976","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:26:35Z","timestamp":1784294795000},"page":"101976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rationale and design of the RISE-HF trial: sucrosomial iron in heart failure"],"prefix":"10.1016","volume":"65","author":[{"given":"Gabriele","family":"Masini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Chiusolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Liga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Giacomo","family":"Galeotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Lattanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Gargani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.ijcha.2026.101976_bb0005","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/cvr\/cvad146","article-title":"Iron deficiency in myocardial ischaemia: molecular mechanisms and therapeutic perspectives","volume":"119","author":"Corradi","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcha.2026.101976_bb0010","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehae284","article-title":"Identification of three mechanistic pathways for iron-deficient heart failure","author":"Packer","year":"2024","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcha.2026.101976_bb0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jacc.2021.11.039","article-title":"Criteria for iron deficiency in patients with heart failure","volume":"79","author":"Masini","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcha.2026.101976_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-025-03671-1","article-title":"Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency","author":"Anker","year":"2025","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.ijcha.2026.101976_bb0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ejhf.2478","article-title":"Health status improvement with ferric carboxymaltose in heart failure with reduced ejection fraction and iron deficiency","volume":"24","author":"Butler","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcha.2026.101976_bb0030","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.freeradbiomed.2013.09.001","article-title":"The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress","volume":"65","author":"Koskenkorva-Frank","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"25","key":"10.1016\/j.ijcha.2026.101976_bb0035","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1016\/j.jacc.2024.03.431","article-title":"Intravenous iron repletion for patients with heart failure and Iron deficiency","volume":"83","author":"Cheema","year":"2024","journal-title":"JACC"},{"issue":"4","key":"10.1016\/j.ijcha.2026.101976_bb0040","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.ijcard.2013.04.181","article-title":"IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia","volume":"168","author":"Beck-Da-Silva","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcha.2026.101976_bb0045","doi-asserted-by":"crossref","DOI":"10.5334\/gh.1151","article-title":"Oral ferrous sulphate improves functional capacity on heart failure patients with iron deficiency anemia","author":"Suryani","year":"2022","journal-title":"Glob. Heart"},{"issue":"19","key":"10.1016\/j.ijcha.2026.101976_bb0050","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1001\/jama.2017.5427","article-title":"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and Iron deficiency: the IRONOUT HF randomized clinical trial","volume":"317","author":"Lewis","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ijcha.2026.101976_bb0055","doi-asserted-by":"crossref","first-page":"e0117383","DOI":"10.1371\/journal.pone.0117383","article-title":"Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis","volume":"10","author":"Tolkien","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ijcha.2026.101976_bb0060","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/ph16060847","article-title":"Sucrosomial\u00ae iron: an updated review of its clinical efficacy for the treatment of iron deficiency","volume":"16","author":"G\u00f3mez-Ram\u00edrez","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"10","key":"10.1016\/j.ijcha.2026.101976_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101349","article-title":"Sucrosomial\u00ae iron supplementation in mice: effects on blood parameters, hepcidin, and inflammation","volume":"10","author":"Asperti","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.ijcha.2026.101976_bb0070","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/ejhf.2092","article-title":"Oral sucrosomial iron improves exercise capacity and quality of life in heart failure with reduced ejection fraction and iron deficiency: a non-randomized, open-label, proof-of-concept study","volume":"23","author":"Karavidas","year":"2021","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.ijcha.2026.101976_bb0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/00015385.2019.1694760","article-title":"Iron deficiency in pulmonary arterial hypertension: prevalence and potential usefulness of oral supplementation","volume":"76","author":"Ghio","year":"2021","journal-title":"Acta Cardiol."},{"key":"10.1016\/j.ijcha.2026.101976_bb0080","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/ejhf.2176","article-title":"Oral sucrosomial iron in heart failure with a reduced ejection fraction","author":"Barakat","year":"2021","journal-title":"Eur. J. Heart Fail."},{"issue":"16","key":"10.1016\/j.ijcha.2026.101976_bb0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/eurheartj\/ehae086","article-title":"Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial","volume":"45","author":"Cleland","year":"2024","journal-title":"Eur. Heart J."},{"issue":"10266","key":"10.1016\/j.ijcha.2026.101976_bb0090","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(20)32339-4","article-title":"Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial","volume":"396","author":"Ponikowski","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijcha.2026.101976_bb0095","article-title":"Minimal clinically important differences in 6-minute walk test in patients with HFrEF and iron deficiency","author":"Khan","year":"2022","journal-title":"J. Card. Fail."},{"issue":"48","key":"10.1016\/j.ijcha.2026.101976_bb0100","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1093\/eurheartj\/ehab411","article-title":"The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapy\u2014the IRON-CRT trial","volume":"42","author":"Martens","year":"2021","journal-title":"Eur. Heart J."},{"issue":"17","key":"10.1016\/j.ijcha.2026.101976_bb0105","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"37","key":"10.1016\/j.ijcha.2026.101976_bb0110","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.ijcha.2026.101976_bb0115","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/ejhf.2338","article-title":"Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish heart failure registry","volume":"23","author":"Becher","year":"2021","journal-title":"Eur. J. Heart Fail."},{"issue":"8","key":"10.1016\/j.ijcha.2026.101976_bb0120","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/ejhf.2879","article-title":"Iron deficiency in heart failure: screening, prevalence, incidence and outcome data from the Swedish Heart Failure Registry and the Stockholm CREAtinine Measurements collaborative project","volume":"25","author":"Lindberg","year":"2023","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.ijcha.2026.101976_bb0125","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jama.2019.22450","article-title":"Effects of iron isomaltoside vs ferric carboxymaltose on hypophosphatemia in iron-deficiency anemia: two randomized clinical trials","volume":"323","author":"Wolf","year":"2020","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ijcha.2026.101976_bb0130","article-title":"Definition of iron deficiency based on the gold standard of bone marrow iron staining in heart failure patients","volume":"11","author":"Beverborg","year":"2018","journal-title":"Circ. Heart Fail."},{"issue":"6","key":"10.1016\/j.ijcha.2026.101976_bb0135","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/ejhf.3237","article-title":"Critical re-evaluation of the identification of iron deficiency states and effective iron repletion strategies in patients with chronic heart failure","volume":"26","author":"Packer","year":"2024","journal-title":"Eur. J. Heart Fail."},{"issue":"10369","key":"10.1016\/j.ijcha.2026.101976_bb0140","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/S0140-6736(22)02083-9","article-title":"Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial","volume":"400","author":"Kalra","year":"2022","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ijcha.2026.101976_bb0145","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1016\/S2352-3026(17)30182-5","article-title":"Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials","volume":"4","author":"Stoffel","year":"2017","journal-title":"Lancet Haematol."},{"issue":"7","key":"10.1016\/j.ijcha.2026.101976_bb0150","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/ejhf.3238","article-title":"Iron homeostasis, recycling and vulnerability in the stressed kidney: a neglected dimension of iron-deficient heart failure","volume":"26","author":"Packer","year":"2024","journal-title":"Eur. J. Heart Fail."},{"issue":"42","key":"10.1016\/j.ijcha.2026.101976_bb0155","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1093\/eurheartj\/ehae359","article-title":"Intravenous iron therapy results in rapid and sustained rise in myocardial iron content through a novel pathway","volume":"45","author":"Vera-Aviles","year":"2024","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcha.2026.101976_bb0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbalip.2014.10.007","article-title":"The isoprostanes\u201425 years later","volume":"1851","author":"Milne","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"}],"container-title":["IJC Heart & Vasculature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906726001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352906726001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:24:13Z","timestamp":1786652653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352906726001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S2352906726001107"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcha.2026.101976","relation":{},"ISSN":["2352-9067"],"issn-type":[{"value":"2352-9067","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of the RISE-HF trial: sucrosomial iron in heart failure","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vasculature","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcha.2026.101976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101976"}}