{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:44Z","timestamp":1788871604406,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23591044"],"award-info":[{"award-number":["23591044"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJC Heart &amp; Vessels"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.ijchv.2013.11.007","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T20:02:05Z","timestamp":1385496125000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity"],"prefix":"10.1016","volume":"2","author":[{"given":"Hiroto","family":"Utsunomiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-1896","authenticated-orcid":false,"given":"Hideya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kunita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2574-0163","authenticated-orcid":false,"given":"Takayuki","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijchv.2013.11.007_bb0005","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","article-title":"Characterization of the early lesion of \u2018degenerative\u2019 valvular aortic stenosis. Histological and immunohistochemical studies","volume":"90","author":"Otto","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0010","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.atherosclerosis.2010.08.072","article-title":"Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"213","author":"Kanjanauthai","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0015","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0020","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jcmg.2011.12.023","article-title":"Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population","volume":"5","author":"Owens","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0025","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000058168.26163.BC","article-title":"Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study","volume":"107","author":"Fox","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/ATVBAHA.111.235234","article-title":"Calcified atherosclerosis in different vascular beds and the risk of mortality","volume":"32","author":"Allison","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0040","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0045","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.amjcard.2011.01.005","article-title":"Relation of mitral annular calcium and coronary calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])","volume":"107","author":"Hamirani","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcct.2009.12.002","article-title":"Relationship of aortic valve calcification with coronary artery calcium severity: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"4","author":"Nasir","year":"2010","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"Lang","year":"2006","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0060","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0002-9149(98)00596-7","article-title":"Mitral annular calcium detected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography","volume":"82","author":"Adler","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0065","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0735-1097(01)01678-3","article-title":"Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age < or =65years old","volume":"38","author":"Jeon","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0070","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0075","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0080","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","article-title":"Human aortic valve calcification is associated with an osteoblast phenotype","volume":"107","author":"Rajamannan","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.105.552844","article-title":"Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis","volume":"113","author":"Allison","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.atherosclerosis.2010.11.017","article-title":"Thoracic aortic calcification and coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA)","volume":"215","author":"Budoff","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0095","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.atherosclerosis.2010.08.070","article-title":"Combined presence of aortic valve calcification and mitral annular calcification as a marker of the extent and vulnerable characteristics of coronary artery plaque assessed by 64-multidetector computed tomography","volume":"213","author":"Utsunomiya","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0100","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2337\/dc12-0134","article-title":"Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes","volume":"35","author":"Rossi","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0105","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.atherosclerosis.2009.10.030","article-title":"Heart valve sclerosis predicts all-cause and cardiovascular mortality","volume":"209","author":"Volzke","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijchv.2013.11.007_bb0110","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ijcard.2009.01.021","article-title":"Cardiac calcification by transthoracic echocardiography in patients with known or suspected coronary artery disease","volume":"142","author":"Corciu","year":"2010","journal-title":"Int J Cardiol"}],"container-title":["IJC Heart &amp; Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214763213000114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214763213000114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:07:52Z","timestamp":1762013272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214763213000114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":22,"alternative-id":["S2214763213000114"],"URL":"https:\/\/doi.org\/10.1016\/j.ijchv.2013.11.007","relation":{},"ISSN":["2214-7632"],"issn-type":[{"value":"2214-7632","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity","name":"articletitle","label":"Article Title"},{"value":"IJC Heart & Vessels","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijchv.2013.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}