{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:26:32Z","timestamp":1762341992330,"version":"3.44.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ijcrp.2022.200166","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T05:19:52Z","timestamp":1673587192000},"page":"200166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prevalence and prognostic implications of hypertensive response to exercise in patients with hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"16","author":[{"given":"Dai-Yin","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Ventoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bereketeab","family":"Haileselassie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraklis","family":"Pozios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yueh","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars L.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Canepa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bavaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Roselle","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-1334","authenticated-orcid":false,"given":"Theodore P.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcrp.2022.200166_bib1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy: a systematic review","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ijcrp.2022.200166_bib2","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMra0902923","article-title":"Inherited cardiomyopathies","volume":"364","author":"Watkins","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcrp.2022.200166_bib3","series-title":"Hypertrophic Cardiomyopathy","first-page":"221","article-title":"Hypertension and hypertrophic cardiomyopathy","author":"Wang","year":"2019"},{"key":"10.1016\/j.ijcrp.2022.200166_bib4","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/01.CIR.92.9.2488","article-title":"Natural history of hypertrophic cardiomyopathy. A population-based study, 1976 through 1990","volume":"92","author":"Cannan","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.ijcrp.2022.200166_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1161\/hy0302.105777","article-title":"Blood pressure response to heart rate during exercise test and risk of future hypertension","volume":"39","author":"Miyai","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcrp.2022.200166_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/sj.jhh.1001157","article-title":"The significance of hypertensive response to exercise as a predictor of hypertension and cardiovascular disease","volume":"15","author":"Sharabi","year":"2001","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.ijcrp.2022.200166_bib7","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1097\/HJH.0b013e32833d455b","article-title":"Association of blood pressure and heart rate response during exercise with cardiovascular events in the Heart and Soul Study","volume":"28","author":"Habibzadeh","year":"2010","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ijcrp.2022.200166_bib8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0002-9149(99)00765-1","article-title":"Maximal exercise systolic pressure, exercise training, and mortality in myocardial infarction patients","volume":"85","author":"Naughton","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib9","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jacc.2020.08.045","article-title":"AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology\/American heart association joint committee on clinical practice guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ijcrp.2022.200166_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ahj.2016.10.010","article-title":"Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy","volume":"184","author":"Sorensen","year":"2017","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcrp.2022.200166_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0735-1097(01)01743-0","article-title":"Hypertensive response to exercise: a potential cause for new wall motion abnormality in the absence of coronary artery disease","volume":"39","author":"Ha","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.CIR.57.3.549","article-title":"The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris","volume":"57","author":"Gobel","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.ijcrp.2022.200166_bib14","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1161\/circ.104.16.1911","article-title":"Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography","volume":"104","author":"Watanabe","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcrp.2022.200166_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jama.281.6.524","article-title":"Impaired chronotropic response to exercise stress testing as a predictor of mortality","volume":"281","author":"Lauer","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.ijcrp.2022.200166_bib16","first-page":"705","article-title":"Exercise testing for chronotropic assessment","volume":"10","author":"Wilkoff","year":"1992","journal-title":"Cardiol. Clin."},{"key":"10.1016\/j.ijcrp.2022.200166_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0735-1097(03)00832-5","article-title":"Prognostic significance of impairment of heart rate response to exercise: impact of left ventricular function and myocardial ischemia","volume":"42","author":"Elhendy","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib18","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0735-1097(98)00377-5","article-title":"Association of chronotropic incompetence with echocardiographic ischemia and prognosis","volume":"32","author":"Lauer","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.amjcard.2005.06.082","article-title":"Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol)","volume":"96","author":"Khan","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.echo.2011.03.006","volume":"24","author":"Nagueh","year":"2011","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcrp.2022.200166_bib21","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.echo.2007.07.003","article-title":"American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography","volume":"20","author":"Pellikka","year":"2007","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcrp.2022.200166_bib22","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.jacc.2007.01.078","article-title":"Tissue Doppler imaging a new prognosticator for cardiovascular diseases","volume":"49","author":"Yu","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006657","article-title":"Clinical outcomes in patients with nonobstructive, labile, and obstructive hypertrophic cardiomyopathy","volume":"7","author":"Lu","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcrp.2022.200166_bib24","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1161\/01.CIR.96.9.2987","article-title":"Prospective prognostic assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy","volume":"96","author":"Sadoul","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ijcrp.2022.200166_bib25","first-page":"306","article-title":"Renin-angiotensin-aldosterone system and physical exercise","volume":"33","author":"Fallo","year":"1993","journal-title":"J. Sports Med. Phys. Fit."},{"key":"10.1016\/j.ijcrp.2022.200166_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0002-9149(90)91139-W","article-title":"Exaggerated pressure response to exercise in men at risk for systemic hypertension","volume":"66","author":"Wilson","year":"1990","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-7120-9-22","article-title":"Stress induced hypertensive response: should it be evaluated more carefully?","volume":"9","author":"Kucukler","year":"2011","journal-title":"Cardiovasc. Ultrasound"},{"key":"10.1016\/j.ijcrp.2022.200166_bib28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0895-7061(03)01003-3","article-title":"Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function","volume":"17","author":"Stewart","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ijcrp.2022.200166_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/ajh\/hps053","article-title":"Exercise-induced hypertension, cardiovascular events, and mortality in patients undergoing exercise stress testing: a systematic review and meta-analysis","volume":"26","author":"Schultz","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ijcrp.2022.200166_bib30","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000231991","article-title":"Left-ventricular power-to-mass ratio at peak exercise predicts mortality, heart failure, and cardiovascular events in patients with stable coronary artery disease: data from the Heart and Soul Study","volume":"114","author":"Farzaneh-Far","year":"2009","journal-title":"Cardiology"},{"key":"10.1016\/j.ijcrp.2022.200166_bib31","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/0735-1097(95)00388-6","article-title":"Angiographic and prognostic implications of an exaggerated exercise systolic blood pressure response and rest systolic blood pressure in adults undergoing evaluation for suspected coronary artery disease","volume":"26","author":"Lauer","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib32","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.amjcard.2015.01.548","article-title":"Exercise heart rates in patients with hypertrophic cardiomyopathy","volume":"115","author":"Luo","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcrp.2022.200166_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jacc.2009.03.060","article-title":"Aortic stiffness is increased in hypertrophic cardiomyopathy with myocardial fibrosis: novel insights in vascular function from magnetic resonance imaging","volume":"54","author":"Boonyasirinant","year":"2009","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487522000423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487522000423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:57:25Z","timestamp":1757415445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772487522000423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":33,"alternative-id":["S2772487522000423"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcrp.2022.200166","relation":{},"ISSN":["2772-4875"],"issn-type":[{"type":"print","value":"2772-4875"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and prognostic implications of hypertensive response to exercise in patients with hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Cardiovascular Risk and Prevention","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcrp.2022.200166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200166"}}