{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T21:08:43Z","timestamp":1761253723604,"version":"3.40.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016355","name":"Xuzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016355","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018636","name":"Xuzhou Science and Technology Program","doi-asserted-by":"publisher","award":["KC20097"],"award-info":[{"award-number":["KC20097"]}],"id":[{"id":"10.13039\/501100018636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ijcrp.2025.200367","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T18:14:32Z","timestamp":1736532872000},"page":"200367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-0342","authenticated-orcid":false,"given":"Binbing","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongneng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5877-2423","authenticated-orcid":false,"given":"Defeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.ijcrp.2025.200367_bib1","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"ESC Scientific Document Group. 2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcrp.2025.200367_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijcard.2013.01.233","article-title":"Validation of the TIMI risk score in Chinese patients presenting to the emergency department with chest pain","volume":"168","author":"Graham","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcrp.2025.200367_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6947-14-12","article-title":"A genetic fuzzy system for unstable angina risk assessment","volume":"14","author":"Dong","year":"2014","journal-title":"BMC Med Inform Decis Mak"},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200367_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/biom11030368","article-title":"Nourin-dependent miR-137 and miR-106b: novel early inflammatory Diagnostic biomarkers for unstable angina patients","volume":"11","author":"Elgebaly","year":"2021","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.ijcrp.2025.200367_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.compbiolchem.2006.08.006","article-title":"Computational identification of microRNAs and their targets","volume":"30","author":"Zhang","year":"2006","journal-title":"Comput. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200367_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200367_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12013-013-9704-7","article-title":"miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease","volume":"68","author":"Ramkaran","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200367_bib8","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biocel.2009.03.002","article-title":"MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease","volume":"42","author":"Townley-Tilson","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200367_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ejhf.244","article-title":"MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure","volume":"17","author":"Watson","year":"2015","journal-title":"Eur. J. Heart Fail."},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200367_bib10","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1161\/ATVBAHA.118.310227","article-title":"Impact of miRNA in atherosclerosis","volume":"38","author":"Lu","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcrp.2025.200367_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/682857","article-title":"MicroRNAs and cardiovascular diseases","volume":"2015","author":"Nishiguchi","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200367_bib12","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1161\/CIRCRESAHA.114.302699","article-title":"Inflammation and its resolution as determinants of acute coronary syndromes","volume":"114","author":"Libby","year":"2014","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200367_bib13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1253\/circj.CJ-18-0063","article-title":"Inflammatory mechanisms of cardiovascular Remodeling","volume":"82","author":"Anzai","year":"2018","journal-title":"Circ. J."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200367_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.thromres.2011.12.026","article-title":"Thrombosis and acute coronary syndrome","volume":"129","author":"Abbate","year":"2012","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200367_bib15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1536\/ihj.18-306","article-title":"Serum circulating miR-150 is a predictor of post-acute myocardial infarction heart failure","volume":"60","author":"Lin","year":"2019","journal-title":"Int. Heart J."},{"key":"10.1016\/j.ijcrp.2025.200367_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphys.2019.00123","article-title":"Circulating MiR-17-5p, MiR-126-5p and MiR-145-3p are novel biomarkers for diagnosis of acute myocardial infarction","volume":"10","author":"Xue","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcrp.2025.200367_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000493419","article-title":"Association of miR-197-5p, a circulating biomarker for heart failure, with myocardial Fibrosis and adverse cardiovascular events among patients with stage C or D heart failure","volume":"141","author":"Liu","year":"2019","journal-title":"Cardiology"},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200367_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/ijerph14050514","article-title":"Two single nucleotide polymorphisms (rs2431697 and rs2910164) of miR-146a are associated with risk of coronary artery disease","volume":"14","author":"Wang","year":"2017","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200367_bib19","doi-asserted-by":"crossref","first-page":"14305","DOI":"10.3390\/ijms160714305","article-title":"Meta-analysis of miR-146a polymorphisms association with coronary artery diseases and ischemic Stroke","volume":"16","author":"Bao","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200367_bib20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/ijms20020293","article-title":"miRNA polymorphisms and risk of Cardio-Cerebrovascular diseases: a Systematic review and Meta-analysis","volume":"20","author":"Bastami","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200367_bib21","first-page":"393","article-title":"Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease","volume":"7","author":"Li","year":"2015","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.ijcrp.2025.200367_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cca.2017.12.037","article-title":"Single nucleotide polymorphisms of microRNA in cardiovascular diseases","volume":"478","author":"Srivastava","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200367_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.hjc.2020.01.005","article-title":"miRNA polymorphisms and risk of premature coronary artery disease","volume":"62","author":"Agiannitopoulos","year":"2021","journal-title":"Hellenic J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200367_bib24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","article-title":"A more meaningful scoring system for determining the severity of coronary heart disease","volume":"51","author":"Gensini","year":"1983","journal-title":"Am. J. Cardiol."},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200367_bib25","doi-asserted-by":"crossref","first-page":"917","DOI":"10.4065\/84.10.917","article-title":"Acute coronary syndromes: diagnosis and management, part I","volume":"84","author":"Kumar","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ijcrp.2025.200367_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.632392","article-title":"Role of MicroRNAs in the Pathogenesis of coronary artery disease","volume":"8","author":"Ghafouri-Fard","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200367_bib27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with Canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcrp.2025.200367_bib28","article-title":"Prognostic Value of plasma Cold-Inducible RNA-binding Protein in patients with acute coronary syndrome","volume":"27","author":"Ren","year":"2022","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200367_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11845-019-02101-9","article-title":"miR-146a and miR-146b predict increased restenosis and rapid angiographic stenotic progression risk in coronary heart disease patients who underwent percutaneous coronary intervention","volume":"189","author":"Zhang","year":"2020","journal-title":"Ir. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200367_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s12967-023-04140-4","article-title":"MiR-146a rs2910164 (G\/C) polymorphism is associated with the development and prognosis of acute coronary syndromes: an observational study including case control and validation cohort","volume":"21","author":"Qiao","year":"2023","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200367_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/jpm12071185","article-title":"MiR-146a Contributes to Thromboinflammation and recurrence in young patients with acute myocardial infarction","volume":"12","author":"de Los Reyes-Garc\u00eda","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.ijcrp.2025.200367_bib32","article-title":"MicroRNA-146a serves as a biomarker for adverse prognosis of ST-segment elevation myocardial infarction","volume":"25","author":"Xiao","year":"2021","journal-title":"Cardiovasc Ther"},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200367_bib33","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3390\/diagnostics12081946","article-title":"miR-146a-5p, miR-223-3p and miR-142-3p as potential predictors of major adverse cardiac events in young patients with acute ST elevation myocardial infarction-added Value over left Ventricular myocardial work Indices","volume":"12","author":"Sc\u0103rl\u0103tescu","year":"2022","journal-title":"Diagnostics"}],"container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525000054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525000054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T16:14:19Z","timestamp":1742487259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772487525000054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":33,"alternative-id":["S2772487525000054"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200367","relation":{},"ISSN":["2772-4875"],"issn-type":[{"type":"print","value":"2772-4875"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Cardiovascular Risk and Prevention","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200367"}}