{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:53:01Z","timestamp":1762645981708,"version":"build-2065373602"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ijcrp.2025.200426","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:25:57Z","timestamp":1747164357000},"page":"200426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study"],"prefix":"10.1016","volume":"26","author":[{"given":"Dongliang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aizeretiaili","family":"Maimaiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6006-0154","authenticated-orcid":false,"given":"Fuhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007618","article-title":"Reduced long\u2010term risk of aortic aneurysm and aortic dissection among individuals with type 2 diabetes mellitus: a nationwide observational study","volume":"7","author":"Avdic","year":"2018","journal-title":"JAHA"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41572-018-0036-1","volume":"4","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib4","first-page":"1198","article-title":"Abdominal aortic aneurysm","volume":"73","author":"Upchurch","year":"2006","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study","volume":"4","author":"Landenhed","year":"2015","journal-title":"JAHA"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib6","doi-asserted-by":"crossref","first-page":"55S","DOI":"10.1016\/j.jvs.2020.05.076","article-title":"Society for Vascular Surgery clinical practice guidelines of thoracic endovascular aortic repair for descending thoracic aortic aneurysms","volume":"73","author":"Upchurch","year":"2021","journal-title":"J. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/jtim-2016-0008","article-title":"Aortic aneurysm","volume":"4","author":"Mathur","year":"2016","journal-title":"J Transl Int Med"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"gh"},{"key":"10.1016\/j.ijcrp.2025.200426_bib9","doi-asserted-by":"crossref","first-page":"312.e5","DOI":"10.1016\/j.avsg.2017.01.022","article-title":"Aortic pathology in systemic lupus erythematosus: a case report and review of literature","volume":"43","author":"Silvestri","year":"2017","journal-title":"Ann. Vasc. Surg."},{"issue":"10354","key":"10.1016\/j.ijcrp.2025.200426_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(22)01349-6","article-title":"Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK","volume":"400","author":"Conrad","year":"2022","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.7696","article-title":"Fatal ascending aortic aneurysm in a patient with systemic lupus erythematosus: a case report","volume":"11","author":"Shahi","year":"2023","journal-title":"Clinical Case Reports"},{"key":"10.1016\/j.ijcrp.2025.200426_bib12","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.2147\/IJN.S452184","article-title":"Innovative diagnosis and therapeutic modalities: engineered exosomes in autoimmune disease","volume":"19","author":"Ji","year":"2024","journal-title":"IJN"},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200426_bib13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.autrev.2012.02.001","article-title":"Updated assessment of the prevalence, spectrum and case definition of autoimmune disease","volume":"11","author":"Hayter","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2020.03.007","article-title":"Challenges, progress, and prospects of developing therapies to treat autoimmune diseases","volume":"181","author":"Fugger","year":"2020","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200426_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022326","article-title":"Increased risk of aortic aneurysm and dissection in patients with Sj\u00f6gren\u2019s syndrome: a nationwide population-based cohort study in Taiwan","volume":"8","author":"Tsai","year":"2018","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200426_bib16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2018.20253","article-title":"Case-control studies","volume":"321","author":"Blakely","year":"2019","journal-title":"JAMA"},{"issue":"9303","key":"10.1016\/j.ijcrp.2025.200426_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(02)07500-1","article-title":"Cohort studies: marching towards outcomes","volume":"359","author":"Grimes","year":"2002","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14397595.2019.1660028","article-title":"A large observational cohort study of rheumatoid arthritis, IORRA: providing context for today's treatment options","volume":"30","author":"Yamanaka","year":"2020","journal-title":"Mod. Rheumatol."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehac636","article-title":"A broader perspective on autoimmune diseases and cardiovascular risk","volume":"44","author":"Pedicino","year":"2023","journal-title":"Eur. Heart J."},{"issue":"10370","key":"10.1016\/j.ijcrp.2025.200426_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0140-6736(22)02474-6","article-title":"Cardiovascular risk in systemic autoimmune diseases","volume":"401","author":"Funada","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12933-023-01974-6","article-title":"Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study","volume":"22","author":"Liu","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ijcrp.2025.200426_bib22","article-title":"Systemic lupus erythematosus and cardiovascular disease: a mendelian randomization study","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijcrp.2025.200426_bib23","article-title":"The association between psoriasis and risk of cardiovascular disease: a mendelian randomization analysis","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijcrp.2025.200426_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.861885","article-title":"Multiple sclerosis and the risk of cardiovascular diseases: a mendelian randomization study","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"19","key":"10.1016\/j.ijcrp.2025.200426_bib25","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200426_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103210","article-title":"Mendelian randomization as a tool to gain insights into the mosaic causes of autoimmune diseases","volume":"21","author":"Chen","year":"2022","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200426_bib27","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s40471-017-0128-6","article-title":"Recent developments in mendelian randomization studies","volume":"4","author":"Zheng","year":"2017","journal-title":"Curr Epidemiol Rep"},{"issue":"47","key":"10.1016\/j.ijcrp.2025.200426_bib28","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1093\/eurheartj\/ehad736","article-title":"Mendelian randomization for cardiovascular diseases: principles and applications","volume":"44","author":"Larsson","year":"2023","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-021-00056-9","article-title":"Genome-wide association studies","volume":"1","author":"Uffelmann","year":"2021","journal-title":"Nat Rev Methods Primers"},{"key":"10.1016\/j.ijcrp.2025.200426_bib30","article-title":"Robust instrumental variable methods using multiple candidate instruments with application to Mendelian randomization","author":"Burgess","year":"2016","journal-title":"arXiv: Methodology"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200426_bib31","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3945\/ajcn.115.118216","article-title":"Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies","volume":"103","author":"Haycock","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1373\/clinchem.2009.141564","article-title":"Mendelian randomization in the era of genomewide association studies","volume":"56","author":"Sleiman","year":"2010","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.ijcrp.2025.200426_bib33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41437-021-00479-w","article-title":"Recent innovations and in-depth aspects of post-genome wide association study (Post-GWAS) to understand the genetic basis of complex phenotypes","volume":"127","author":"Mortezaei","year":"2021","journal-title":"Heredity"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200426_bib34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta\u2010analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"issue":"16","key":"10.1016\/j.ijcrp.2025.200426_bib35","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomization","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib36","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41467-021-21015-8","article-title":"GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility","volume":"12","author":"Eriksson","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib37","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","year":"2013","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200426_bib38","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"issue":"7863","key":"10.1016\/j.ijcrp.2025.200426_bib39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","article-title":"Interpreting type 1 diabetes risk with genetics and single-cell epigenomics","volume":"594","author":"Chiou","year":"2021","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200426_bib40","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200426_bib41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.ijcrp.2025.200426_bib42","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ng.2770","article-title":"Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis","volume":"45","year":"2013","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2108672119","article-title":"Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study","volume":"119","author":"Chia","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200426_bib44","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1097\/j.pain.0000000000002922","article-title":"Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling","volume":"164","author":"Zorina-Lichtenwalter","year":"2023","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib45","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jhep.2021.04.055","article-title":"An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs","volume":"75","author":"Cordell","year":"2021","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib46","article-title":"Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine mapping in the MHC and genome wide","volume":"3","author":"Stuart","year":"2022","journal-title":"Human Genet. Genom. Adv."},{"issue":"7488","key":"10.1016\/j.ijcrp.2025.200426_bib47","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib48","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41588-021-00870-7","article-title":"Computationally efficient whole-genome regression for quantitative and binary traits","volume":"53","author":"Mbatchou","year":"2021","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200426_bib49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ng.3434","article-title":"Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus","volume":"47","author":"Bentham","year":"2015","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.ijcrp.2025.200426_bib50","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41588-021-00954-4","article-title":"A generalized linear mixed model association tool for biobank-scale data","volume":"53","author":"Jiang","year":"2021","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.ijcrp.2025.200426_bib51","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/ng.3680","article-title":"Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants","volume":"48","author":"Jin","year":"2016","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200426_bib52","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ajhg.2021.06.016","article-title":"Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm","volume":"108","author":"Roychowdhury","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ijcrp.2025.200426_bib53","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.3","article-title":"Guidelines for performing Mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2023","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.ijcrp.2025.200426_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"16","key":"10.1016\/j.ijcrp.2025.200426_bib55","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1158\/0008-5472.CAN-20-0985","article-title":"LDtrait: an online tool for identifying published phenotype associations in linkage disequilibrium","volume":"80","author":"Lin","year":"2020","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.ijcrp.2025.200426_bib56","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/ije\/dyx028","article-title":"Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique","volume":"45","author":"Hartwig","year":"2016","journal-title":"Int. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib57","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200426_bib58","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib59","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib60","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib61","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib62","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0962280210394459","article-title":"Using multiple genetic variants as instrumental variables for modifiable risk factors","volume":"21","author":"Palmer","year":"2012","journal-title":"Stat. Methods Med. Res."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib63","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"CRP CHD Genetics Collaboration. Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib64","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ije\/dyt179","article-title":"Calculating statistical power in Mendelian randomization studies","volume":"42","author":"Brion","year":"2013","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archsurg.1996.01430130087017","article-title":"Features of autoimmunity in the abdominal aortic aneurysm","volume":"131","author":"Gregory","year":"1996","journal-title":"Arch. Surg."},{"issue":"Supplement_2","key":"10.1016\/j.ijcrp.2025.200426_bib66","doi-asserted-by":"crossref","first-page":"ehad655","DOI":"10.1093\/eurheartj\/ehad655.3223","article-title":"B cells and immunoglobulins promotes aortic dissection in mice","volume":"44","author":"Ohno","year":"2023","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib67","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0741-5214(03)00340-9","article-title":"Inflammatory aortic aneurysm is associated with increased incidence of autoimmune disease","volume":"38","author":"Haug","year":"2003","journal-title":"J. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib68","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12872-024-03876-1","article-title":"The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib69","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1749-6632.2001.tb03976.x","article-title":"Abdominal aortic aneurysm as an autoimmune disease","volume":"947","author":"Hirose","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200426_bib70","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.molmed.2008.09.008","article-title":"Abdominal aortic aneurysms: an autoimmune disease?","volume":"14","author":"Jagadesham","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ijcrp.2025.200426_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1087978","article-title":"Analysis of immunogenic cell death in ascending thoracic aortic aneurysms based on single-cell sequencing data","volume":"14","author":"Tian","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib72","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2249.2005.02938.x","article-title":"Predominance of type 1 CD4+T cells in human abdominal aortic aneurysm","volume":"142","author":"Galle","year":"2005","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0021-9150(03)00282-X","article-title":"Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms","volume":"170","author":"Ocana","year":"2003","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib74","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molmed.2004.01.002","article-title":"T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection","volume":"10","author":"Vallejo","year":"2004","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib75","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1062-1458(97)83259-X","article-title":"Nitric oxide and endothelial dysfunction","volume":"6","year":"1997","journal-title":"ACC Curr. J. Rev."},{"issue":"24","key":"10.1016\/j.ijcrp.2025.200426_bib76","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1073\/pnas.87.24.10043","article-title":"Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells","volume":"87","author":"Radomski","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib77","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cardiores.2004.06.020","article-title":"Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress","volume":"64","author":"Clapp","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib78","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jtcvs.2005.09.018","article-title":"Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections","volume":"131","author":"He","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.maturitas.2014.04.012","article-title":"Impact of inflammation on vascular disease in hypertension","volume":"78","author":"Virdis","year":"2014","journal-title":"Maturitas"},{"issue":"28","key":"10.1016\/j.ijcrp.2025.200426_bib80","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.2174\/1381612827666210210142200","article-title":"Thoracic aortic aneurysm: blood pressure and inflammation as key factors in the development of aneurysm dissection","volume":"27","author":"Postnov","year":"2021","journal-title":"CPD"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib81","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCULATIONAHA.107.690982","article-title":"Aortic Aneurysms :an immune disease with a strong genetic components","volume":"117","author":"Kuivaniemi","year":"2008","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib82","first-page":"711","article-title":"Surgical treatment of abdominal aortic aneurysms","volume":"63","author":"May","year":"1968","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib83","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/096721099400200205","article-title":"Abdominal aortic aneurysm Surgery: something old, something new","volume":"2","author":"Tilson","year":"1994","journal-title":"Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-4804(86)90002-8","article-title":"Why small caliber vascular grafts fail: a review of clinical and experimental experience and the significance of the interaction of blood at the interface","volume":"41","author":"Esquivel","year":"1986","journal-title":"J. Surg. Res."},{"issue":"6","key":"10.1016\/j.ijcrp.2025.200426_bib85","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0741-5214(93)90550-6","article-title":"Hemodynamics and aneurysm development in vascular allografts","volume":"18","author":"Petersen","year":"1993","journal-title":"J. Vasc. Surg."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib86","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02018860","article-title":"Experimental study of determinants of aneurysmal expansion of the abdominal aorta","volume":"8","author":"Anidjar","year":"1994","journal-title":"Ann. Vasc. Surg."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200426_bib87","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI200419855","article-title":"Th2-predominant inflammation and blockade of IFN-\u03b3 signaling induce aneurysms in allografted aortas","volume":"114","author":"Shimizu","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib88","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2164-8-237","article-title":"Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms","volume":"8","author":"Lenk","year":"2007","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib89","first-page":"306","article-title":"Polimialgia reumatica e coinvolgimento dell\u2019aorta toracica","volume":"15","author":"Lorenzi","year":"2014","journal-title":"Giorn. Ital. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib90","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-med-060911-090007","article-title":"Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus","volume":"64","author":"Kahlenberg","year":"2013","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/rheumatology\/kem202","article-title":"Systemic inflammation as a risk factor for atherothrombosis","volume":"47","author":"Leuven","year":"2008","journal-title":"Rheumatology"},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200426_bib92","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3390\/ijms19071890","article-title":"Systemic inflammatory response and atherosclerosis: the paradigm of chronic inflammatory rheumatic diseases","volume":"19","author":"Arida","year":"2018","journal-title":"IJMS"},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200426_bib93","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.cyto.2012.02.010","article-title":"Atherogenic effects of TNF-\u03b1 and IL-6 via up-regulation of scavenger receptors","volume":"58","author":"Hashizume","year":"2012","journal-title":"Cytokine"},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200426_bib94","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1172\/JCI38308","article-title":"An adventitial IL-6\/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice","volume":"119","author":"Tieu","year":"2009","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200426_bib95","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0741-5214(94)70169-5","article-title":"Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall","volume":"20","author":"Newman","year":"1994","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcrp.2025.200426_bib96","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000228900","article-title":"Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall","volume":"76","author":"Reeps","year":"2009","journal-title":"Pathobiology"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200426_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07495-1","article-title":"Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells","volume":"9","author":"Hadi","year":"2018","journal-title":"Nat Commun"}],"container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:49:32Z","timestamp":1762645772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772487525000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":97,"alternative-id":["S2772487525000649"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200426","relation":{},"ISSN":["2772-4875"],"issn-type":[{"type":"print","value":"2772-4875"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Cardiovascular Risk and Prevention","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200426"}}