{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:50:27Z","timestamp":1787061027099,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijcrp.2025.200535","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:34:31Z","timestamp":1761204871000},"page":"200535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mean platelet volume and long-term cardiovascular outcomes in patients with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-9701","authenticated-orcid":false,"given":"Shani","family":"Dahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ygal","family":"Plakht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Shiyovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Ben Assa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrukh","family":"Almazzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Melamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Nahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Patalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Lev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.ijcrp.2025.200535_bib1","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11883-014-0401-9","article-title":"Pathophysiology of acute coronary syndrome","volume":"16","author":"Santos-Gallego","year":"2014","journal-title":"Curr. Atheroscler. Rep."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1538-7836.2009.03584.x","article-title":"Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta\u2010analysis","volume":"8","author":"Chu","year":"2010","journal-title":"J. Thromb. Haemostasis"},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200535_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0953710042000267707","article-title":"Mean platelet volume in patients with type 2 diabetes mellitus","volume":"15","author":"Papanas","year":"2004","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12872-025-04811-8","article-title":"Usefulness of platelet mass index in the prediction of angiographic no-reflow in patients with acute ST-segment elevation myocardial infarction","volume":"25","author":"S\u00f6kmen","year":"2025","journal-title":"BMC Cardiovasc. Disord."},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200535_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2024.103337","article-title":"Correlation between platelet metrics and cardiovascular risk in prediabetes with coronary artery disease: a two-year cross-sectional study","volume":"36","author":"Kumar","year":"2024","journal-title":"J. King Saud Univ. Sci."},{"key":"10.1016\/j.ijcrp.2025.200535_bib7","series-title":"Forum Multimedia Publishing","article-title":"Comparison of platelet mass index in on-pump and off-pump coronary artery bypass surgery","author":"G\u00fcnday","year":"2020"},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5114\/amsad.2016.64444","article-title":"Platelet mass index is increased in psoriasis. A possible link between psoriasis and atherosclerosis","volume":"1","author":"Unal","year":"2016","journal-title":"Arch Med Sci-Atheroscler Dis."},{"issue":"17","key":"10.1016\/j.ijcrp.2025.200535_bib9","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/euhj.2000.2515","article-title":"Platelet activation: assessment and quantification","volume":"22","author":"Kamath","year":"2001","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.ijcrp.2025.200535_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1023\/B:EJEP.0000006635.36802.c8","article-title":"The epidemiology of diabetes in a large Israeli HMO","volume":"18","author":"Chodick","year":"2002","journal-title":"Eur. J. Epidemiol."},{"issue":"3a","key":"10.1016\/j.ijcrp.2025.200535_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/00031305.1982.10482817","article-title":"The likelihood ratio, wald, and lagrange multiplier tests: an expository note","volume":"36","author":"Buse","year":"1982","journal-title":"Am. Statistician"},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200535_bib13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1161\/01.RES.0000264509.36234.51","article-title":"Clinical aspects of platelet inhibitors and thrombus formation","volume":"100","author":"Meadows","year":"2007","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.ijcrp.2025.200535_bib12","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1182\/blood-2003-08-2804","article-title":"Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions","volume":"103","author":"Coppinger","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200535_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/oxfordjournals.eurheartj.a060141","article-title":"Haematological prognostic indices after myocardial infarction: evidence from the diet and reinfarction trial (DART)","volume":"13","author":"Burr","year":"1992","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11239-013-0876-1","article-title":"Mean platelet volume as a predictor for long-term outcome after percutaneous coronary intervention","volume":"36","author":"Eisen","year":"2013","journal-title":"J. Thromb. Thrombolysis"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.09.009","article-title":"Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year","volume":"22","author":"Ar\u00e9valo-Lorido","year":"2013","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.03.003","article-title":"Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke","volume":"19","author":"Mayda-Doma\u00e7","year":"2010","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200535_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1160\/TH13-10-0845","article-title":"Increased mean platelet volume is associated with non-responsiveness to clopidogrel","volume":"112","author":"Asher","year":"2014","journal-title":"Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200535_bib25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1080\/07853890410017386","article-title":"Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy","volume":"36","author":"Nadar","year":"2004","journal-title":"Ann. Med."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200535_bib26","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/09537100120058810","article-title":"Altered megakaryocyte\u2013platelet haemostatic axis in hypercholesterolaemia","volume":"12","author":"Pathansali","year":"2001","journal-title":"Platelets"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2257.1992.tb00103.x","article-title":"Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis","volume":"14","author":"Kario","year":"1992","journal-title":"Clin. Lab. Haematol."},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200535_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1742-1241.2005.00500.x","article-title":"The mean platelet volume in patients with obesity","volume":"59","author":"Coban","year":"2005","journal-title":"Int. J. Clin. Pract."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib29","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1038\/s41598-018-25058-8","article-title":"Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease","volume":"8","author":"Rief","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcrp.2025.200535_bib30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.atherosclerosis.2018.08.048","article-title":"Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease","volume":"277","author":"Wada","year":"2018","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.ijcrp.2025.200535_bib31","first-page":"739","article-title":"Mean platelet volume in diabetes mellitus","volume":"86","author":"Sharpe","year":"1993","journal-title":"QJM Int J Med."},{"issue":"7948","key":"10.1016\/j.ijcrp.2025.200535_bib32","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0140-6736(75)90610-8","article-title":"Platelet abnormalities in diabetic peripheral neuropathy","volume":"306","author":"O\u2019malley","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.ijcrp.2025.200535_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00251891","article-title":"A study of platelet-relevant parameters in patients with diabetic microangiopathy","volume":"25","author":"Porta","year":"1983","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcrp.2025.200535_bib34","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM198409063111010","article-title":"Platelets and diabetes mellitus","volume":"311","author":"Mustard","year":"1984","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib35","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2362.1981.tb02116.x","article-title":"Platelet function in diabetes mellitus in relationship to complications, glycosylated haemoglobin and serum lipoproteins","volume":"11","author":"Betteridge","year":"1981","journal-title":"Eur. J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200535_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.dsx.2016.08.014","article-title":"Mean paltelet volume (MPV) the neglected marker of cardiovascular risk and glycosylated hemoglobin in diabetic patient","volume":"11","author":"Agrawal","year":"2017","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-0041-1726468","article-title":"Relationship between mean platelet volume and critical limb ischemia in diabetes mellitus patients","volume":"30","author":"Rachmanadi","year":"2021","journal-title":"Int. J. Angiol."},{"issue":"4","key":"10.1016\/j.ijcrp.2025.200535_bib38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/00033197221105753","article-title":"Evaluation of intermountain risk score for short-and long-term mortality in ST elevation myocardial infarction patients","volume":"74","author":"\u00c7\u0131nar","year":"2023","journal-title":"Angiology"},{"issue":"2","key":"10.1016\/j.ijcrp.2025.200535_bib39","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MCA.0000000000001219","article-title":"Prognostic value of intermountain risk score for short-and long-term mortality in patients with cardiogenic shock","volume":"34","author":"\u0130lker","year":"2023","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ijcrp.2025.200535_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.thromres.2019.05.008","article-title":"Modulation of megakaryopoiesis and platelet production during inflammation","volume":"179","author":"Couldwell","year":"2019","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200535_bib41","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1189\/jlb.1RU0916-391RR","article-title":"Development of platelets during steady state and inflammation","volume":"101","author":"M\u00fcller-Newen","year":"2017","journal-title":"J Leucoc Biol"},{"issue":"3","key":"10.1016\/j.ijcrp.2025.200535_bib42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.12997\/jla.2022.11.3.280","article-title":"The triglyceride-glucose index can predict long-term major adverse cardiovascular events in Turkish patients with high cardiovascular risk","volume":"11","author":"Hay\u0131ro\u011flu","year":"2022","journal-title":"J Lipid Atheroscler"},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200535_bib43","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2217\/bmm-2023-0113","article-title":"Admission triglyceride-glucose index is predictor of long-term mortality and appropriate implantable cardiac defibrillator therapy in patients with heart failure","volume":"17","author":"\u00d6zcan","year":"2023","journal-title":"Biomarkers Med."},{"issue":"5","key":"10.1016\/j.ijcrp.2025.200535_bib44","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jtha.2023.01.018","article-title":"Alterations in platelet proteome signature and impaired platelet integrin \u03b1IIb\u03b23 activation in patients with COVID-19","volume":"21","author":"Goudswaard","year":"2023","journal-title":"J. Thromb. Haemostasis"},{"issue":"11","key":"10.1016\/j.ijcrp.2025.200535_bib45","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/CIRCRESAHA.120.317703","article-title":"Platelets can associate with SARS-CoV-2 RNA and are hyperactivated in COVID-19","volume":"127","author":"Zaid","year":"2020","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ijcrp.2025.200535_bib46","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCRESAHA.122.321930","article-title":"Platelets and SARS-CoV-2 during COVID-19: immunity, thrombosis, and beyond","volume":"132","author":"Sciaudone","year":"2023","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.ijcrp.2025.200535_bib47","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.3390\/ijms24097975","article-title":"Thrombotic mechanism involving platelet activation, hypercoagulability and hypofibrinolysis in coronavirus disease 2019","volume":"24","author":"Wada","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ijcrp.2025.200535_bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/ijms26010049","article-title":"Complex pattern of platelet activation\/reactivity after SARS-CoV-2 infection","volume":"26","author":"Luzak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.ijcrp.2025.200535_bib49","doi-asserted-by":"crossref","DOI":"10.1161\/HCQ.0000000000000111","article-title":"AHA\/ACC key data elements and definitions for cardiovascular and noncardiovascular complications of COVID-19: a report of the American college of Cardiology\/American heart association task force on clinical data standards","volume":"15","author":"Bozkurt","year":"2022","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"8","key":"10.1016\/j.ijcrp.2025.200535_bib50","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/cvr\/cvac195","article-title":"Association of COVID-19 with short-and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank","volume":"119","author":"Wan","year":"2023","journal-title":"Cardiovasc. Res."}],"container-title":["International Journal of Cardiology Cardiovascular Risk and Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525001734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772487525001734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T17:36:25Z","timestamp":1765128985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772487525001734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S2772487525001734"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200535","relation":{},"ISSN":["2772-4875"],"issn-type":[{"value":"2772-4875","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mean platelet volume and long-term cardiovascular outcomes in patients with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology Cardiovascular Risk and Prevention","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcrp.2025.200535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200535"}}