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The schizophrenic patients tend to social isolation. In addition, considerable evidence from behavioral and neurochemistry studies strongly implicate the dopamine (DA) system and the medial part of the prefrontal cortex (mPFC) in the pathophysiology of the social isolation syndrome. In order to assess effects of the postweaning social isolation (pwSI) on the DA system of the nVH lesions, we investigated the DA content and its metabolite, DOPAC in different limbic subregions in rats postpubertally at postnatal day (P) 78 following nVH lesions at P7 with and without pwSI for 8 weeks. The DA and DOPAC were measured by HPLC with electrochemical detection. The nVH lesion induces increase in the DA content in the hippocampus with no effect in the mPFC, nucleus accumbens and caudate\u2010putamen, while the pwSI induces major increase in the DA content in limbic subregions such as the mPFC, nucleus accumbens and hipocampus with opposite effect in the caudate\u2010putamen. These results suggest that while pwSI has an effect in the postpubertal content of DA in both sham and nVH lesions in rats, the nVH\u2010lesioned rats appear to be affected to a greater extent than the sham animals underscoring the influence of pwSI differences in the development of behaviors in the nVH\u2010lesioned animals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2003.12.003","type":"journal-article","created":{"date-parts":[[2004,2,11]],"date-time":"2004-02-11T05:12:47Z","timestamp":1076476367000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Neonatal ventral hippocampus lesion alters the dopamine content in the limbic regions in postpubertal rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Glenda","family":"Alquicer","sequence":"first","affiliation":[{"name":"Laboratorio de Neuropsiquiatr\u0131\u0301a Instituto de Fisiolog\u0131\u0301a Universidad Aut\u00f3noma de Puebla 14 Sur 6301 CP 72570 Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana B.","family":"Silva\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuropsiquiatr\u0131\u0301a Instituto de Fisiolog\u0131\u0301a Universidad Aut\u00f3noma de Puebla 14 Sur 6301 CP 72570 Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Peralta","sequence":"additional","affiliation":[{"name":"Centro Internacional de Psicoterapia e Investigaci\u00f3n 6 norte 202D CP 72760 Cholula Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Flores","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuropsiquiatr\u0131\u0301a Instituto de Fisiolog\u0131\u0301a Universidad Aut\u00f3noma de Puebla 14 Sur 6301 CP 72570 Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,10]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Diagnostic and Statistic Manual of Mental Disorders","author":"American Psychiatry Association","year":"1994"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0003-3472(67)90018-8","article-title":"Comparison of behavioural development in socially isolated and grouped rats","volume":"15","author":"Baenninger L.P.","year":"1976","journal-title":"Anim. 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