{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:15:44Z","timestamp":1761822944132},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T00:00:00Z","timestamp":1157673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The effects of retrograde neuronal death is well determined in dorsal root ganglia (DRG) after peripheral nerve injury, but the effects of intracerebral hemorrhage on the DRG has not been well known. In this study, it was investigated if hemorrhagic lesions of sensory\u2013motor cortex cause neurodegeneration on DRG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study was conducted on 23 male hybrid rabbits. Three of 23 animals were examined as control. Left parietal burr\u2010hole surgery was applied to remaining 20 animals and autolog blood of 0.25 ml injected into left sensory\u2013motor region under general anesthesia. All rabbits were followed\u2010up for two months and sacrificed. L<jats:sub>5<\/jats:sub> DRG's were observed histopathologically. The results were analyzed with Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Right spastic hemiplegia developed only in 16 operated animals and 10 of them were developed ileus. The number of degenerated neurons in DRG was higher in the plegic side than in the non\u2010plegic side (<jats:italic>p<\/jats:italic> &lt; 0.001). But, the difference between the non\u2010plegic side of the study group and control group did not meaningful (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intracerebral hemorrhages affecting the sensory\u2013motor cortex may result in neurodegeneration in DRG. Sensitive reflex arches of striated muscles and bowels may be disturbed due to DRG degeneration and results in spasticity and\/or ileus.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2006.07.001","type":"journal-article","created":{"date-parts":[[2006,9,9]],"date-time":"2006-09-09T11:17:27Z","timestamp":1157800647000},"page":"455-459","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ganglionary mechanisms of spasticity and ileus in cerebral hemorrhage: an experimental study"],"prefix":"10.1002","volume":"24","author":[{"given":"Mehmet Dumlu","family":"Aydin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Riza","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salih Cenap","family":"Cevli","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemal","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senol","family":"Dane","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semih","family":"Diyarbakirli","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty of Ataturk University 25100 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1011935122963","article-title":"Sciatic nerve transection in neonatal rats induces apoptotic neuronal death in L5 dorsal root ganglion","volume":"30","author":"Bahadori M.H.","year":"2001","journal-title":"J. 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