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The wild\u2010type (+\/+) and homozygous <jats:italic>weaver<\/jats:italic> (<jats:italic>wv<\/jats:italic>\/<jats:italic>wv<\/jats:italic>) mice used here were the offspring of pregnant dams injected with the radioactive precursor when the mesencephalic neurons were being produced (gestational days 11\u201315). Data reveal that, at postnatal day 90, depletion of TH\u2010stained cells in the <jats:italic>wv<\/jats:italic>\/<jats:italic>wv<\/jats:italic> presented an A\/P pattern of increasing severity and, therefore, the DA cells located in posterior parts of the SNc or the VTA appear to be more vulnerable than the settled anterior neurons. When the time of neuron origin is inferred for each level of these cell groups, it is found that the neurogenesis span is similar for both experimental groups, although significant deficits in the frequency of <jats:italic>wv<\/jats:italic>\/<jats:italic>wv<\/jats:italic> late\u2010generated neurons were observed in any level considered. On the other hand, it has been found that TH\u2010positive neurons were settled along the extent of the SNc and the VTA following precise and differential neurogenetic gradients. Thus, the acute rostrocaudal increase in the proportion of late\u2010generated neurons detected in both +\/+ DA\u2010cell groups is disturbed in the <jats:italic>weaver<\/jats:italic> homozygotes due to the indicated A\/P depletion.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.05.002","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T00:08:46Z","timestamp":1179533326000},"page":"299-307","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Generation and survival of midbrain dopaminergic neurons in <i>weaver<\/i> mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Joaqu\u00edn","family":"Mart\u00ed","sequence":"first","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Ciencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Santa\u2010Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Ciencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley A.","family":"Bayer","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Neurobiology Indianapolis IN 46278 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana School of Medicine Indianapolis IN 46202 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P.","family":"Herv\u00e1s","sequence":"additional","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Ciencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"148","volume-title":"Are dopaminergic neurons selectively vulnerable to Parkinson's disease?","author":"Agid Y.","year":"1993"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1460-9568.1997.tb01360.x","article-title":"Vulnerability of midbrain dopaminergic neurons in calbindin\u2010D28k, \u2010deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in MPTP\u2010treated and weaver mice","volume":"9","author":"Aisraksinen M.S.","year":"1997","journal-title":"Eur. 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