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However, the mechanism underlying maternal diabetes\u2010induced congenital malformations including spina bifida is not fully understood. It was hypothesized that hyperglycemic conditions affect the proliferation and apoptosis of neural progenitor cells in the developing spinal neural tube, leading to abnormal neurodevelopment. In the present study, biological processes such as proliferation and apoptosis were investigated in the neuroepithelial cells of the developing spinal neural tube of embryos from diabetic mice, and in embryonic spinal neural tube derived neural progenitor cell cultures exposed to high glucose <jats:italic>in vitro<\/jats:italic>. Maternal diabetes caused decreased proliferation and increased apoptosis of the neuroepithelial cells in the developing spinal cord of embryos from diabetic mouse. Decreased proliferation and increased apoptosis were also found in neural progenitor cells exposed to high glucose. In addition, high glucose\u2010induced apoptosis in neural progenitor cells was associated with activation of caspase\u20103. Thus, high glucose disturbs both proliferation and cell death of neural progenitors in the developing spinal neural tube. This could provide a cellular mechanism by which maternal hyperglycemia induces spina bifida in embryos from diabetic pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.08.002","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T12:45:21Z","timestamp":1187613921000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Hyperglycemic condition disturbs the proliferation and cell death of neural progenitors in mouse embryonic spinal cord"],"prefix":"10.1002","volume":"25","author":[{"given":"Qing","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology School of Medicine, Shandong University 44 Wenhua Xi Road Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Mao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology 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