{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:35:26Z","timestamp":1760888126953},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005277","name":"Presbyterian Historical Society","doi-asserted-by":"publisher","award":["NS 35059"],"award-info":[{"award-number":["NS 35059"]}],"id":[{"id":"10.13039\/100005277","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>This report describes a new experimental model to evaluate the effect of a recurrent systemic inflammatory challenge, after cerebral hypoxia\u2010ischemia in immature mice, on the progression of brain injury. Treatment with a low dose of lipopolysaccharide (<jats:italic>E. coli<\/jats:italic> O55:B5, 0.2 mg\/kg for 3 days, then 0.1 mg\/kg for 2 days) daily for 5 days after unilateral cerebral hypoxia\u2010ischemia (right carotid ligation followed by 35 min in 10% O<jats:sub>2<\/jats:sub>) in 10\u2010day\u2010old mice resulted in increased right forebrain tissue damage (35.6% reduction in right hemisphere volume compared to 20.6% reduction in saline\u2010injected controls), in bilateral reductions in corpus callosum area (by 12%) and myelin basic protein immunostaining (by 19%), and in suppression of injury\u2010related right subventricular zone cellular proliferation. The post\u2010hypoxic\u2010ischemic lipopolysaccharide regimen that amplified brain injury was not associated with increased mortality, nor with changes in body temperature, weight gain or blood glucose concentrations. The results of the present study demonstrate that systemic inflammation influences the evolution of tissue injury after neonatal cerebral hypoxia\u2010ischemia and may also impair potential recovery mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.08.005","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T11:16:05Z","timestamp":1187867765000},"page":"57-65","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of indolent inflammation on neonatal hypoxic\u2010ischemic brain injury in mice"],"prefix":"10.1002","volume":"26","author":[{"given":"John D.E.","family":"Barks","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shangguan","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Pfau","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye S.","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Michigan Medical School Ann Arbor MI 48109 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.193"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981201)54:5<574::AID-JNR2>3.0.CO;2-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn738"},{"key":"e_1_2_6_5_1","volume-title":"Birth Asphyxia and the Brain: Basic Science and Clinical Implications","author":"Barks J.D.E.","year":"2002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600160"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2234031100"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080713"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01474.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20623"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00399-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.09.062"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20272"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000190020.30282.cc"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000191140.87314.ce"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1432609100"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199910000-00006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200201000-00007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1215"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1767"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2000.01412.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088417"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440413"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858403252680"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.04.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90043-A"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000123906.17746.00"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00804.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00892-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00075-7"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6391"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04483.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.011"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01472-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2677"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21068"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2003.00174.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70432-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20013"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574807001050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574807001050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2007.08.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2007.08.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2007.08.005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2007.08.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:17:14Z","timestamp":1694031434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2007.08.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,22]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1016\/j.ijdevneu.2007.08.005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2007.08.005","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,22]]},"assertion":[{"value":"2007-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}