{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:54:43Z","timestamp":1768452883437,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"De Reuter, Schmidheiny and Boninchi Foundations"},{"name":"Swiss National Foundation","award":["31-64030.00"],"award-info":[{"award-number":["31-64030.00"]}]},{"name":"Eagle Foundation and by the European Community","award":["512012-2005"],"award-info":[{"award-number":["512012-2005"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Neurogenesis is nearly completed after birth, whereas gliogenic activities remain intense during the postnatal period in the developing rat cortex. These include involution of radial glia, proliferation of astrocytes and oligodendrocytes and myelin formation. Little is known about the effects of hypoxic\u2013ischemic (HI) injury on these critical postnatal processes. Here we explored the glial reactions to mild HI injury of the neonatal rat cerebral cortex at P3. We show that the HI lesion results in disruption of the normal radial glia architecture, which was paralleled by an increase in GFAP immunopositive reactive astrocytes. The morphology of these latter cells and the fact that they were immunolabelled for both nestin and GFAP suggest an accelerated transformation of radial glia into astrocytes. In addition, BrdU\/GFAP immunostaining revealed a significant increase of double\u2010labelled cells indicating an acute proliferation of astrocytes after HI. This enhanced proliferative activity of astrocytes persisted for several weeks. We found an elevated number and increased mitotic activity of both NG2\u2010positive oligodendrocyte progenitors and RIP\u2010positive oligodendrocytes after injury. These findings imply that glial responses are central to cortical tissue remodelling following neonatal ischemia and represent a potential target for therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.08.014","type":"journal-article","created":{"date-parts":[[2007,9,11]],"date-time":"2007-09-11T11:08:46Z","timestamp":1189508926000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Glial responses to neonatal hypoxic\u2013ischemic injury in the rat cerebral cortex"],"prefix":"10.1002","volume":"26","author":[{"given":"St\u00e9phane V.","family":"Sizonenko","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine, University of Geneva Switzerland"},{"name":"Department of Fundamental Neurosciences School of Medicine, University of Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily J.","family":"Camm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine, University of Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Dayer","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences School of Medicine, University of Geneva Switzerland"},{"name":"Department of Psychiatry School of Medicine, University of Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozsef Z.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences School of Medicine, University of Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10087"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-16-06241.1998"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-01302.2001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.037"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440040204"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00171-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00032-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01811-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20000901)61:5<471::AID-JNR1>3.0.CO;2-N"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-12-07616.1994"},{"key":"e_1_2_7_15_1","first-page":"61","article-title":"Astrogliosis and blood vessel development during human spinal cord myelination","volume":"38","author":"Dziewulska D.","year":"2000","journal-title":"Folia Neuropathol."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00060-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.6.572"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.3.455"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70251-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199911)46:5<755::AID-ANA11>3.0.CO;2-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00058-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(98)80033-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90048-G"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046149"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(96)00157-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200201000-00007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03308.2003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0788"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010835404754"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10593"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406295586"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072270"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00750-5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000179381.86809.02"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.6.541"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970301)47:5<455::AID-JNR1>3.0.CO;2-G"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00300010"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02513-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10203"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03148-1"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000072517.01207.87"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000157673.36848.67"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl168"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.08.058"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-10-04240.2003"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200107200-00025"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03317-1"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00036-9"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.6.580"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085978"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902890106"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00003"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310104"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4247-05.2006"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20332"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20013"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07238.1995"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574807001141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574807001141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2007.08.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2007.08.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2007.08.014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2007.08.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:17:11Z","timestamp":1694031431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2007.08.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,10]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1016\/j.ijdevneu.2007.08.014"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2007.08.014","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,10]]},"assertion":[{"value":"2007-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}