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Chronic hyperhomocysteinemia was induced from the 6th to the 28th day of life by subcutaneous injection of homocysteine (0.3\u20130.6 \u03bcmol\/g), twice a day; control Wistar rats received the same volume of saline solution (0.9% NaCl). Half of the homocysteine\u2010 and saline\u2010treated groups also received intraperitoneal administration of folate (0.011 \u03bcmol\/g) from the 6th to the 28th day of life. A group of animals was killed 12 h after the last injection, plasma and parietal cortex were collected for biochemical analysis. Another group stayed at Central Animal House until 60th day of life, when the rats were submitted to behavioral testing in water maze or were killed for evaluation of cortical Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase activity. Results showed that hyperhomocysteinemia impaired reference memory for platform location, as assessed by fewer crossings to the platform place and increased latency for the first crossing, when compared to controls. In the working memory task homocysteine\u2010treated animals also needed more time to find the platform. We also observed that Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase activity was reduced in parietal cortex of hyperhomocysteinemic rats sacrificed 12 h after the last injection of homocysteine (29\u2010day\u2010old rats). In contrast, this enzyme was not altered when the rats were sacrificed 31 days after the treatment (60\u2010day\u2010old rats). Hyperhomocysteinemic rats treated with folate had all those impairments prevented, an effect probably related to folate antioxidant properties.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.10.003","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T12:32:14Z","timestamp":1191933134000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Concurrent folate treatment prevents Na<sup>+<\/sup>,K<sup>+<\/sup>\u2010ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development"],"prefix":"10.1002","volume":"25","author":[{"given":"Cristiane","family":"Matt\u00e9","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilene B.S.","family":"Scherer","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli M.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleth\u00e9a G.","family":"Barschak","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen R.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Netto","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela T.S.","family":"Wyse","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600\u2010Anexo CEP 90035\u2010003 Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450490430543"},{"key":"e_1_2_7_3_1","first-page":"253","article-title":"Regulation of Na+, \u2010K+, \u2010Pump activity: pathways between receptors and effectors","volume":"10","author":"Bertorello A.M.","year":"1995","journal-title":"News Physiol. 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