{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:59:41Z","timestamp":1791118781968,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation of Committee of China","award":["30371849"],"award-info":[{"award-number":["30371849"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Intrauterine asphyxia is one of the major contributors for perinatal death, mental and physical disorders of surviving children. Brain\u2010derived neurotrophic factor (BDNF) provides a promising solution to hypoxic injury due to its survival\u2010promoting effects. In an attempt to identify possible molecular mechanisms underlying the neuroprotective role of BDNF, we studied extracellular signal\u2010regulated kinase (ERK), phosphatidylinositol 3\u2010kinase (PI\u20103\u2010K) and p38 mitogen\u2010activated protein kinase (MAPK) pathways. We demonstrated that BDNF protected cortical neurons against hypoxic injury <jats:italic>in vitro<\/jats:italic> via activation of both the ERK and PI\u20103\u2010K pathways but not the p38 MAPK pathway. We also showed that both hypoxic stimuli and exogenous BDNF treatment phosphorylated the cyclic AMP response element\u2010binding protein (CREB) and that CREB phosphorylation induced by BDNF was mediated via the ERK pathway in cultured cortical neurons.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2007.11.005","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T16:27:00Z","timestamp":1198081620000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Neuroprotection of brain\u2010derived neurotrophic factor against hypoxic injury <i>in vitro<\/i> requires activation of extracellular signal\u2010regulated kinase and phosphatidylinositol 3\u2010kinase"],"prefix":"10.1002","volume":"26","author":[{"given":"Xiaomei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Immunology West China University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West China Second University Hospital, Sichuan University Chengdu 610041 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,17]]},"reference":[{"issue":"1","key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/exnr.2000.7492","article-title":"BDNF protects against spatial memory deficits following neonatal hypoxia\u2013ischemia","volume":"166","author":"Almli C.R.","year":"2000","journal-title":"Exp. 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