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We also examined whether this increased cerebral O<jats:sub>2<\/jats:sub> consumption was related to changes in the activity of the gamma\u2010aminobutyric acid (GABA) inhibitory system. Young (4 weeks) male control Long Evans (<jats:italic>n<\/jats:italic> = 14) and Eker (<jats:italic>n<\/jats:italic> = 14) rats (70\u2013100 g) were divided into control and bicuculline (1 mg\/kg\/min for 2 min then 0.1 mg\/kg\/min for 13 min, GABA<jats:sub>A<\/jats:sub> receptor antagonist) treated animals. Cerebral regional blood flow (<jats:sup>14<\/jats:sup>C\u2010iodoantipyrine) and O<jats:sub>2<\/jats:sub> consumption (cryomicrospectrophotometry) were determined in isoflurane anesthetized rats. We found significantly increased basal O<jats:sub>2<\/jats:sub> consumption in the cortex (6.3 \u00b1 0.7 ml O<jats:sub>2<\/jats:sub>\/min\/100 g Eker vs. 5.1 \u00b1 0.2 ml O<jats:sub>2<\/jats:sub>\/min\/100 g control), hippocampus and cerebellum, but not the pons. Regional cerebral blood flow was also elevated in the cortex and hippocampus in Eker rats at baseline, but cerebral O<jats:sub>2<\/jats:sub> extractions were similar. Bicuculline significantly increased O<jats:sub>2<\/jats:sub> consumption in the cortex (6.5 \u00b1 0.3) and all other regions of the control rats, but had no effect on cortex (5.9 \u00b1 1.5) or other regions of the Eker rats. Cerebral blood flow followed a similar pattern. In conclusion, Eker rats had significantly elevated cerebral O<jats:sub>2<\/jats:sub> consumption and blood flow, but this was not affected by GABA receptor blockade. This suggested a reduced activity of the GABA<jats:sub>A<\/jats:sub> receptor in the brains of Eker rats. This may have important implications in the treatment of autism.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2008.01.002","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T12:36:48Z","timestamp":1200400608000},"page":"517-521","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cerebral O<sub>2<\/sub> consumption in young Eker rats, effects of GABA blockade: implications for autism"],"prefix":"10.1002","volume":"26","author":[{"given":"Harvey R.","family":"Weiss","sequence":"first","affiliation":[{"name":"Department of Physiology &amp; Biophysics University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School 675 Hoes Lane West Piscataway NJ 08854\u20105635 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School 675 Hoes Lane West Piscataway NJ 08854\u20105635 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oak Z.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School 675 Hoes Lane West Piscataway NJ 08854\u20105635 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2006.00253.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(05)71007-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.04083.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.2.414"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-2005-861379","article-title":"Effects of 17beta\u2010estradiol on blood\u2010brain barrier disruption in focal ischemia during GABAA receptor inhibition","volume":"37","author":"Chi O.Z.","year":"2005","journal-title":"Horm. 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