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We found that after treatment of rats with the mitochondrial neurotoxin 3\u2010nitropropionic acid, the expression of cell cycle markers of G1 phase measured by immunohistochemistry was induced in the striatal brain region. Furthermore, we detected an increase in the nuclear and also cytoplasmatic E2F\u20101 expression, suggesting that this protein could activate the apoptotic cascade in rat brain. Western blot analysis of post\u2010mortem brain samples from patients also showed an increase in the expression of E2F\u20101 and cyclin D1 in comparison with control samples. 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