{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:07:09Z","timestamp":1791299229134,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T00:00:00Z","timestamp":1218499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Neural progenitor cell transplantation has emerged as a promising approach for cell replacement therapy in the brain of neurodegenerative diseases. These are multipotent stem cells with self\u2010renewal capabilities and can give rise to cells of all the three lineages of nervous system and can be maintained and differentiated to desirable neuronal subtypes<jats:italic>in vitro<\/jats:italic>with known trophic factors. However, like fetal cells, neural progenitor cells after differentiating to specific neuronal type also require continuous neurotrophic factor support for their long\u2010term survival following transplantation. Recent reports suggest that olfactory ensheathing cells are capable of providing continuous neurotrophic factor to the transplanted neural progenitor cells for their long\u2010term survival. In the present investigation, an attempt has been made to validate functional restoration in kainic acid lesioned rat model of cognitive dysfunction following co\u2010transplantation of neural progenitor cells with olfactory ensheathing cells.<\/jats:p><jats:p>Animals lesioned with kainic acid in CA3 subfield of hippocampal region were transplanted with neural progenitor cells, olfactory ensheathing cells or neural progenitor cells + olfactory ensheathing cells together. Twelve weeks post\u2010transplantation functional restoration was assessed using neurobehavioral, neurochemical, and immunohistochemical approaches. Significant recovery in learning and memory (89%) was observed in co\u2010transplanted group when compared to lesioned group. This was accompanied by significantly higher expression of choline acetyltransferase and restoration in cholinergic receptor binding in co\u2010transplanted group (61%) over the animals transplanted either olfactory ensheathing cells or neural progenitor cells alone. Role of olfactory ensheathing cells in supplementing neurotrophic factors was further substantiated<jats:italic>in vitro<\/jats:italic>by pronounced differentiation of neural progenitor cells to choline acetyltransferase\/acetylcholine esterase immunoreactive cells when co\u2010cultured with olfactory ensheathing cells as compared to neural progenitor cells alone. The results strengthened the hypothesis that co\u2010transplantation of olfactory ensheathing cells and neural progenitor cells may be a better approach for functional restoration in kainic acid induced rat model of cognitive dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2008.08.002","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T08:40:20Z","timestamp":1218616820000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Long\u2010term functional restoration by neural progenitor cell transplantation in rat model of cognitive dysfunction: co\u2010transplantation with olfactory ensheathing cells for neurotrophic factor support"],"prefix":"10.1002","volume":"27","author":[{"given":"N.","family":"Srivastava","sequence":"first","affiliation":[{"name":"Developmental Toxicology Division Indian Institute of Toxicology Research Mahatma Gandhi Marg, Post Box 80 Lucknow 226001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Seth","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division Indian Institute of Toxicology Research Mahatma Gandhi Marg, Post Box 80 Lucknow 226001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.K.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division Indian Institute of Toxicology Research Mahatma Gandhi Marg, Post Box 80 Lucknow 226001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.","family":"Ansari","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division Indian Institute of Toxicology Research Mahatma Gandhi Marg, Post Box 80 Lucknow 226001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division Indian Institute of Toxicology Research Mahatma Gandhi Marg, Post Box 80 Lucknow 226001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,12]]},"reference":[{"issue":"3","key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2004.04.014","article-title":"Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a co\u2010transplantation approach with fetal ventral mesencephalic cells","volume":"16","author":"Agrawal A.K.","year":"2004","journal-title":"Neurobiol. 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