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MA treatment increases corticosterone release in an age\u2010dependent U\u2010shaped pattern that corresponds to the stress hyporesponsive period (SHRP; P4\u201315). Here we tested the hypothesis that the cognitive effects induced by MA are associated with treatment that begins within the SHRP. Three treatment regimens were compared, P1\u201310, P6\u201315, and P11\u201320. One male\/female pair\/litter received 0, 10, or 25 mg\/kg MA\/dose (four doses\/day at 2 h intervals given s.c. with 19\u201321 litters\/regimen). Locomotor activity and acoustic startle were tested as behaviors not predicted to be associated with the SHRP. Cincinnati and Morris water maze findings were consistent with the hypothesis in that MA\u2010treated animals exposed from P6\u201315 or P11\u201320 showed impaired learning compared to those exposed from P1\u201310; however, on probe trials in the Morris water maze, MA\u2010induced memory impairments were not regimen\u2010specific and were contributed to by all treatment regimens. All MA treatment regimens induced reductions in locomotor activity and acoustic startle facilitation as expected. No differential effect on prepulse trials was seen suggesting no impairment in sensory gating. Cognitive deficits from neonatal MA treatment are associated with the SHRP and may be the product of hypothalamic\u2013pituitary\u2013adrenal (HPA) axis dysregulation during critical periods of brain development.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2008.12.003","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T10:29:47Z","timestamp":1230200987000},"page":"289-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of (+)\u2010methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Charles V.","family":"Vorhees","sequence":"first","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Skelton","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis E.","family":"Grace","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tori L.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon L.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Braun","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"83","article-title":"Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer S.A.","year":"1993","journal-title":"Neurotoxicology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207458909002151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.06.004"},{"key":"e_1_2_6_5_1","first-page":"228","article-title":"Methamphetamine abuse during pregnancy and its health impact on neonates born at Siriraj Hospital, Bangkok, Thailand","volume":"35","author":"Chomchai C.","year":"2004","journal-title":"Southeast Asian J. 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