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Pups were exposed from 3rd to 7th postnatal day to ZnCl<jats:sub>2<\/jats:sub> (27 mg\/kg\/day, s.c.) and subsequently to HgCl<jats:sub>2<\/jats:sub> (5 doses of 5 mg\/kg\/day, s.c.). Each litter contained two rats for each treatment. The rats were submitted to behavioral task and litters were killed at 13 or 33 days old for acetylcholinesterase activity assays and for the determination of metal levels. Based on the results obtained from 13\u2010day\u2010old rats, they were divided in two groups of litters that were defined at the end of the experimental period (33 days) as less sensitive rats to mercury and more sensitive rats to mercury in accordance with the recovery of body weight until day 33. The mercury exposure caused accumulation of this metal in cerebrum and cerebellum in all mercury treated rats, and inhibited the cerebellum acetylcholinesterase activity from 13\u2010day\u2010old rats. Besides, the mercury\u2010animals of the most sensitive litters to mercury presented impairment in motor function and muscular strength verified in the beaker test, as well as a reduction of the locomotor and exploratory activities in the open field task. Zinc partially prevented all the alterations induced by mercury exposure and reduced the mercury level accumulated in cerebrum and cerebellum. This study confirms the preventive effect of zinc on behavioral alterations induced by mercury in young rats and demonstrates that the mercury behavioral effects are present even for a long time after the end of the exposure.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2009.05.002","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T17:19:23Z","timestamp":1242407963000},"page":"459-468","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["ZnCl<sub>2<\/sub> exposure protects against behavioral and acetylcholinesterase changes induced by HgCl<sub>2<\/sub>"],"prefix":"10.1002","volume":"27","author":[{"given":"C.","family":"Franciscato","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.R.","family":"Goulart","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Lovatto","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.A.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.M.","family":"Flores","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.L.","family":"Dressler","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.C.","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"},{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"},{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria 97.105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420060406"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.07.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.05.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.09.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_174.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2006.12.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.07.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.21.1.347"},{"key":"e_1_2_6_11_1","first-page":"211","volume-title":"Chemical Toxicology Clinical Chemistry Metals","author":"Clarkson T.W.","year":"1983"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408369708998098"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marenvres.2004.03.086"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(89)90173-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.11.032"},{"key":"e_1_2_6_16_1","first-page":"533","article-title":"Effects of toluene exposure during gestation on neurobehavioral development of rats and hamsters","volume":"23","author":"Da\u2010Silva V.A.","year":"1990","journal-title":"Braz. 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