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Animals were randomly divided into four groups of six each: group I served as control which received standard diet; group II received only MMI (250 mg L<jats:sup>\u22121<\/jats:sup><jats:sub>,<\/jats:sub> orally); group III received both MMI (250 mg L<jats:sup>\u22121<\/jats:sup>, orally) and Se (0.5 mg kg<jats:sup>\u22121<\/jats:sup> of diet); group IV served as a positive control and received Se (0.5 mg kg<jats:sup>\u22121<\/jats:sup> of diet) as sodium selenite (Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub>). Treatments were started from the 14th day of pregnancy until day 14 after delivery. In the MMI\u2010treated group, plasma\u2010free thyroid hormone levels (FT<jats:sub>3<\/jats:sub> and FT<jats:sub>4<\/jats:sub>), protein, DNA and RNA contents in cerebrum and cerebellum decreased when compared to control. Co\u2010treatment with Se ameliorated these parameters. In the MMI\u2010treated group, antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH\u2010Px) significantly decreased, while malonaldialdehyde (MDA) levels in cerebrum and cerebellum increased. Co\u2010administration of Se through the diet restored these parameters to near normal values. The biochemical modifications are correlated histologically with the abnormal development of an external granular layer, indicating a delay of granular cells migration towards the molecular layer in the MMI\u2010treated group. Our results showed that Se improved cerebrum and cerebellum MMI\u2010induced damages in suckling rats. Moreover, we concluded that Se is an important neuroprotective element that may be used as a dietary supplement against brain impairments.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2009.07.002","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T00:16:27Z","timestamp":1247876187000},"page":"719-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Ibtissem","family":"Ben Amara","sequence":"first","affiliation":[{"name":"Animal Physiology Laboratory Sfax Faculty of Science BP 1171 3000 Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamadi","family":"Fetoui","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory Sfax Faculty of Science BP 1171 3000 Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhel","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service, CHU Habib Bourguiba 3029 Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Zeghal","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory Sfax Faculty of Science BP 1171 3000 Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1385\/BTER:103:1:059","article-title":"Sodium selenite stimulates neurobehavior and neurochemical activities in rats","volume":"103","author":"Ahmad A.S.","year":"2005","journal-title":"Biol. 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