{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:38:02Z","timestamp":1747737482899},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T00:00:00Z","timestamp":1249430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Project B05 15958"],"award-info":[{"award-number":["Project B05 15958"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study different malformations of the cochlea could be demonstrated. Nevertheless, we could not delineate a distinct malformation of the inner ear, that can be linked to a neural tube defect.<\/jats:p><jats:p>Neural tube defects are a frequent and heterogeneous group of malformations, ranging from the survivable spina bifida to fatal anencephaly. In multiple animal models an involvement of the vestibulocochlear system has been demonstrated. In this article human fetal temporal bones of neural tube defects were analysed in a multimodular work\u2010up.<\/jats:p><jats:p>The morphologic study was performed with light microscopy, transmission electron microscopy and synchrotron radiation\u2010based microcomputed tomography. Immunohistochemistry for different neuronal markers such as peripherin, beta\u2010III\u2010tubulin and vimentin helped to evaluate ontogenetic tissue development.<\/jats:p><jats:p>Eight fetal temporal bones with neural tube defects and five control temporal bones were included into the morphologic study. The morphologic results of the neural tube defect temporal bones showed six regularly developed cochleas and two with only a single cochlear turn. Three of the neural tube defect temporal bones were further examined with immunohistochemical analysis. No differences in the staining pattern for peripherin, beta\u2010III\u2010tubulin and vimentin were detected.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2009.07.008","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T09:47:12Z","timestamp":1249552032000},"page":"669-676","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The cochlea in fetuses with neural tube defects"],"prefix":"10.1002","volume":"27","author":[{"given":"Joachim","family":"Schmutzhard","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Glueckert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bitsche","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Falkeis","sequence":"additional","affiliation":[{"name":"Institute of Pathology Innsbruck Medical University Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Schwentner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Riechelmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Biomaterials Science Center University of Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Institute for Materials Research GKSS\u2010Research Center Geesthacht Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consolato","family":"Sergi","sequence":"additional","affiliation":[{"name":"Institute for Materials Research GKSS\u2010Research Center Geesthacht Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Schrott\u2010Fischer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Innsbruck Medical University Anichstrasse 35 A \u2010 6020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1117\/12.452866","article-title":"Microtomography using synchrotron radiation as a user experiment at beamlines BW2 and BW5 of HASYLAB at DESY","author":"Beckmann F.","year":"2002","journal-title":"Proc. SPIE"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1097\/00001756-200409150-00002","article-title":"Development of the inner ear in Splotch mutant mice","volume":"13","author":"Buckiova D.","year":"2004","journal-title":"Neuroreport"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/bdrc.20025","article-title":"Investigations into the etiology of neural tube defects","volume":"4","author":"Cabrera R.M.","year":"2004","journal-title":"Birth Defects Res. C: Embryo Today"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrg1181","article-title":"The genetic basis of mammalian neurulation","volume":"10","author":"Copp A.J.","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00374-9"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.c.30052","article-title":"Epithelial cell polarity genes are required for neural tube closure","volume":"1","author":"Doudney K.","year":"2005","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/AUD.0b013e3181906c30","article-title":"Morphology studies of the human fetal cochlea in Turner syndrome","volume":"1","author":"Fish J.H.","year":"2009","journal-title":"Ear Hear"},{"key":"e_1_2_4_9_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1017\/S0022215100089684","article-title":"Temporal bone studies in anencephaly","volume":"8","author":"Friedmann I.","year":"1980","journal-title":"J. Laryngol. Otol."},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-5955(00)00149-0","article-title":"Differential expression of beta tubulin isotypes in the adult gerbil cochlea","volume":"1","author":"Hallworth R.","year":"2000","journal-title":"Hear Res."},{"issue":"3","key":"e_1_2_4_11_1","first-page":"2","article-title":"Congenital malformations of the inner ear: a classification based on embryogenesis","volume":"97","author":"Jackler R.K.","year":"1987","journal-title":"Laryngoscope"},{"key":"e_1_2_4_12_1","volume-title":"Principles of Computerised Tomographic Imaging","author":"Kak A.C.","year":"1988"},{"key":"e_1_2_4_13_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cm.10116","article-title":"Class III beta\u2010tubulin in human development and cancer","volume":"2","author":"Katsetos C.D.","year":"2003","journal-title":"Cell Motil. Cytoskel."},{"key":"e_1_2_4_14_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-3523-4","volume-title":"Fetal and Neonatal Pathology","author":"Keeling J.W.","year":"1987"},{"key":"e_1_2_4_15_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroscience.2007.08.032","article-title":"New insights into peripherin expression in cochlear neurons","volume":"1","author":"Lallemend F.","year":"2007","journal-title":"Neuroscience"},{"key":"e_1_2_4_16_1","first-page":"15","article-title":"Prevalence of spina bifida at birth\u2014United States, 1983\u20131990: a comparison of two surveillance systems","volume":"2","author":"Lary J.M.","year":"1996","journal-title":"MMWR CDC Surveill. Summ."},{"key":"e_1_2_4_17_1","first-page":"1","article-title":"Expression of peripherin in the pig spiral ganglion\u2014aspects of nerve injury and regeneration","author":"Liu W.","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1096-9861(19990405)406:2<183::AID-CNE4>3.0.CO;2-K","article-title":"Class III beta\u2010tubulin expression in sensory and nonsensory regions of the developing avian inner ear","volume":"2","author":"Molea D.","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_4_19_1","first-page":"178","article-title":"Non\u2010destructive three\u2010dimensional evaluation of biocompatible materials by micotomography using synchotron radiation","author":"M\u00fcller B.","year":"2001","journal-title":"Proc. SPIE"},{"key":"e_1_2_4_20_1","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","article-title":"Severe neural tube defects in the loop\u2010tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification","volume":"22","author":"Murdoch J.N.","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/geno.2001.6638","article-title":"Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop\u2010tail mutation","volume":"1","author":"Murdoch J.N.","year":"2001","journal-title":"Genomics"},{"key":"e_1_2_4_22_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-5876(01)00459-1","article-title":"Temporal bone histopathology in trisomy 22","volume":"2","author":"Ohtani I.","year":"2001","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"e_1_2_4_23_1","first-page":"393","article-title":"Effects of cadmium on the hearing system","volume":"3","author":"Ozcaglar H.U.","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"e_1_2_4_24_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1741-4520.2006.00104.x","article-title":"Etiology, pathogenesis and prevention of neural tube defects","volume":"2","author":"Padmanabhan R.","year":"2006","journal-title":"Congenit. Anom. (Kyoto)"},{"key":"e_1_2_4_25_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/tera.1420350103","article-title":"Abnormalities of the ear associated with exencephaly in mouse fetuses induced by maternal exposure to cadmium","volume":"1","author":"Padmanabhan R.","year":"1987","journal-title":"Teratology"},{"key":"e_1_2_4_26_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1542\/peds.109.3.409","article-title":"A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention","volume":"3","author":"Rintoul N.E.","year":"2002","journal-title":"Pediatrics"},{"key":"e_1_2_4_27_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1288\/00005537-197309000-00006","article-title":"Development and cell kinetics of the kreisler (kr\u2010kr) mouse","volume":"9","author":"Ruben R.J.","year":"1973","journal-title":"Laryngoscope"},{"key":"e_1_2_4_28_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/BF00463937","article-title":"Intermediate filaments in the cochleas of normal and mutant (w\/wv, sl\/sld) mice","volume":"4","author":"Schrott A.","year":"1988","journal-title":"Arch. Otorhinolaryngol."},{"key":"e_1_2_4_29_1","first-page":"451","article-title":"Pigment anomaly\u2010associated inner ear deafness","volume":"5","author":"Schrott A.","year":"1987","journal-title":"Acta Otolaryngol."},{"key":"e_1_2_4_30_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1258\/0022215011906876","article-title":"Occipital meningocele and Mondini deformity of the cochlea","volume":"1","author":"Smith O.D.","year":"2001","journal-title":"J. Laryngol. Otol."},{"key":"e_1_2_4_31_1","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1523\/JNEUROSCI.16-19-06157.1996","article-title":"Hair cell differentiation in chick cochlear epithelium after aminoglycoside toxicity: in vivo and in vitro observations","volume":"19","author":"Stone J.S.","year":"1996","journal-title":"J. Neurosci."},{"key":"e_1_2_4_32_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/archotol.1983.00800220059015","article-title":"Temporal bone findings in trisomy 13 with cyclopia","volume":"8","author":"Tomoda K.","year":"1983","journal-title":"Arch. Otolaryngol."},{"key":"e_1_2_4_33_1","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.0712126105","article-title":"Genetic interaction between members of the Vangl family causes neural tube defects in mice","volume":"9","author":"Torban E.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_2_4_34_1","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1523\/JNEUROSCI.4698-05.2005","article-title":"The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner\u2010ear sensory hair cells","volume":"8","author":"Wang Y.","year":"2006","journal-title":"J. Neurosci."},{"key":"e_1_2_4_35_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/tera.1420460103","article-title":"In vitro approaches to the elucidation of mechanisms of chemical teratogenesis","volume":"1","author":"Welsch F.","year":"1992","journal-title":"Teratology"},{"issue":"1","key":"e_1_2_4_36_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/000348948609500509","article-title":"Auditory and temporal bone abnormalities in CHARGE association","volume":"5","author":"Wright C.G.","year":"1986","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"e_1_2_4_37_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.heares.2004.08.007","article-title":"Hearing loss associated with enlarged vestibular aqueduct and Mondini dysplasia is caused by splice\u2010site mutation in the PDS gene","volume":"1","author":"Yang J.J.","year":"2005","journal-title":"Hear Res."}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574809001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574809001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2009.07.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2009.07.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2009.07.008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2009.07.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:46:00Z","timestamp":1694069160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2009.07.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,5]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1016\/j.ijdevneu.2009.07.008"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2009.07.008","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,5]]},"assertion":[{"value":"2009-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}