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We report here that PS1 is also required for maturation and\/or maintenance of the pituitary gland. We generated PS1\u2010conditional knockout (PS1\u2010cKO) mice by crossing floxed PS1 and Wnt1\u2010cre mice, in which PS1 was lacking in the neural crest\u2010derived cell lineage. Although the PS1\u2010cKO mice exhibited no obvious phenotypic abnormalities for several days after birth, reduced body weight in the mutant was evident by the age of 3\u20135 weeks. Pituitary weight and serum insulin\u2010like growth factor (IGF)\u20101 level were also reduced in the mutant. Histologic analysis revealed severe atrophy of the cytosol in the anterior and intermediate pituitary lobes of the mutant. Immunohistochemistry did not reveal clear differences in the expression levels of thyroid\u2010stimulating hormone, adrenocorticotropic hormone, or prolactin in the mutant pituitary. In contrast, growth hormone expression levels were reduced in the anterior lobe of the mutant. PS1 was defective in the posterior lobe, but not the anterior or intermediate lobes, in the mutant pituitary. These findings suggest that PS1 indirectly mediates the development and\/or maintenance of the anterior and intermediate lobes in the pituitary gland via actions in other regions, such as the posterior lobe.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2009.08.003","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T07:15:51Z","timestamp":1249974951000},"page":"837-843","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Restricted growth and insulin\u2010like growth factor\u20101 deficiency in mice lacking presenilin\u20101 in the neural crest cell lineage"],"prefix":"10.1002","volume":"27","author":[{"given":"Mitsunari","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Pharmacology School of Clinical Pharmacy College of Pharmaceutical Sciences Matsuyama University 4\u20102 Bunkyo\u2010cho Matsuyama 790\u20108578 Ehime 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