{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:53Z","timestamp":1760217293242},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T00:00:00Z","timestamp":1266883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["RO1 DA006733","T32 ES007031"],"award-info":[{"award-number":["RO1 DA006733","T32 ES007031"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Neonatal rat methamphetamine (MA) exposure has been shown to cause long\u2010term behavioral impairments similar to some of those observed following neonatal stress. The mechanism by which MA induces impairments is unknown but may be related to early increases in corticosterone release. We previously developed a method to attenuate MA\u2010induced corticosterone release using adrenal autotransplantation (ADXA) in neonatal rats. This exposure period corresponds to the second\u2010half of human pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether inhibition of neonatal MA\u2010induced increases in corticosterone attenuates the long\u2010term behavioral deficits associated with early MA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADXA successfully attenuated MA\u2010induced plasma corticosterone increases by \u223c50% during treatment (P11\u201320) but did not attenuate the long\u2010term behavioral effects of MA treatment. MA\u2010treated rats, regardless of surgery, showed increased errors and latencies in the Cincinnati water maze test of egocentric learning and increased latency, path length, and cumulative distance in three phases of Morris water maze spatial learning and reference memory. MA\u2010treated offspring were hypoactive, had subtle reductions in anxiety in the elevated zero maze but not in the light\u2010dark test. ADXA had no effect on MA\u2010induced long\u2010term 5\u2010HT reductions in the neostriatum or entorhinal cortex or on 5\u2010HIAA reductions in the hippocampus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fifty percent attenuation of neonatal MA\u2010induced elevations in corticosterone does not alter the long\u2010term egocentric or allocentric learning deficits or other behavioral effects of neonatal MA exposure. Because the ADXA effect was partial, the data cannot rule out the possibility that a more complete block of MA\u2010induced corticosterone release might not prevent later cognitive deficits.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2010.02.005","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T09:34:41Z","timestamp":1267004081000},"page":"331-342","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of inhibiting neonatal methamphetamine\u2010induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels"],"prefix":"10.1002","volume":"28","author":[{"given":"Curtis E.","family":"Grace","sequence":"first","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tori L.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon L.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Skelton","sequence":"additional","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles V.","family":"Vorhees","sequence":"additional","affiliation":[{"name":"Division of Neurology Dept. of Pediatrics Cincinnati Children's Research Foundation Cincinnati OH United States"},{"name":"University of Cincinnati College of Medicine Cincinnati OH United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.12.013"},{"key":"e_1_2_12_3_1","first-page":"83","article-title":"Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer S.A.","year":"1993","journal-title":"Neurotoxicology"},{"key":"e_1_2_12_4_1","first-page":"245","article-title":"Ultrastructural observations on the regeneration of adrenocortical autotransplants in the rat spleen","volume":"135","author":"Belloni A.S.","year":"1982","journal-title":"J. Anat."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(98)00019-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460150072026"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.06.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10066"},{"key":"e_1_2_12_9_1","first-page":"228","article-title":"Methamphetamine abuse during pregnancy and its health impact on neonates born at Siriraj Hospital, Bangkok, Thailand, Southeast Asian","volume":"35","author":"Chomchai C.","year":"2004","journal-title":"J. Trop. Med. Public Health"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.01.014"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/NI:5:1:79","article-title":"Web\u2010based method for translating neurodevelopment from laboratory species to humans","volume":"5","author":"Clancy B.","year":"2006","journal-title":"Neuroinformatics"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000346516.49126.20"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10197"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb24976.x"},{"key":"e_1_2_12_15_1","first-page":"436","article-title":"Effects of transplacental exposure to cocaine and methamphetamine on the neonate","volume":"150","author":"Dixon S.D.","year":"1989","journal-title":"West J. Med."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80661-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10173"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.199.1.201"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00551.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.100156"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20470"},{"key":"e_1_2_12_22_1","unstructured":"GraceC.E. SchaeferT.L. GudelskyG.A. WilliamsM.T. VorheesC.V.(in press).Neonatal adrenal autotransplantation in neonatal rats treated with methamphetamine: A method for attenuating drug\u2010induced corticosterone release without altering drug\u2010induced brain serotonin reductions. Neurotoxicology and Teratology."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200112000-00020"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100701"},{"key":"e_1_2_12_25_1","first-page":"1","volume-title":"Monitoring the Future National Survey Results on Drug Use, 1975\u20132007. Volume I: Secondary School Students","author":"Johnston L.D.","year":"2008"},{"key":"e_1_2_12_26_1","first-page":"1","volume-title":"Monitoring the Future National Survey Results on Drug Use, 1975\u20132007. Volume II: College Students and Adults Ages 19\u201345","author":"Johnston L.D.","year":"2008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00781-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.10.054"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420240803"},{"key":"e_1_2_12_30_1","first-page":"541","article-title":"Methamphetamine abuse during pregnancy: outcome and fetal effects","volume":"72","author":"Little B.B.","year":"1988","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_12_31_1","first-page":"365","article-title":"Allocentric spatial learning by hippocampectomised rats: a further test of the \u201cspatial mapping\u201d and \u201cworking memory\u201d theories of hippocampal function","volume":"38","author":"Morris R.G.","year":"1986","journal-title":"Q. J. Exp. Psychol. B"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1212009"},{"key":"e_1_2_12_33_1","first-page":"269","article-title":"Neurotoxic effects of substituted amphetamines in rats and mice","author":"O'Callaghan J.P.","year":"2002","journal-title":"Challenges Curr. Dogma"},{"key":"e_1_2_12_34_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000129196","article-title":"Experimental study on adrenal autografts in rats to preserve normal adrenocortical function after bilateral adrenalectomy","volume":"24","author":"Okamoto T.","year":"1992","journal-title":"Eur. Surg. Res."},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80125-7"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0018-506X(03)00063-1"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579401003029"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(86)90010-X"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04034.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05112.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00376.1995"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.05.004"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200302000-00006"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2007.09.005"},{"key":"e_1_2_12_45_1","first-page":"1","volume-title":"Systematic Review of Treatment for Amphetamine\u2010related Disorders","author":"Srisurapanont M.","year":"2001"},{"key":"e_1_2_12_46_1","first-page":"41","article-title":"Adrenal autotransplantation","volume":"28","author":"Srougi M.","year":"1978","journal-title":"Urol. Surv."},{"key":"e_1_2_12_47_1","first-page":"109","article-title":"Influence of exogenous glucocorticoids and adrenocorticotropic hormone on experimental adrenal autografts","volume":"29","author":"Srougi M.","year":"1978","journal-title":"Surg. Forum"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199204000-00005"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a5ec6f"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00534.x"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092320211"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(87)90008-0"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02249328"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.04.002"},{"key":"e_1_2_12_55_1","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1523\/JNEUROSCI.20-12-04732.2000","article-title":"Adult learning deficits after neonatal exposure to d, \u2010methamphetamine: selective effects on spatial navigation and memory","volume":"20","author":"Vorhees C.V.","year":"2000","journal-title":"J. Neurosci."},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.12.003"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(91)90013-M"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00300-X"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.11.001"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(00)00091-X"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1433-y"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10159"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890600902842"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03620-X"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574810000365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574810000365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2010.02.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2010.02.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2010.02.005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2010.02.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:08:48Z","timestamp":1694066928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2010.02.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,23]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1016\/j.ijdevneu.2010.02.005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2010.02.005","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,23]]},"assertion":[{"value":"2009-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}