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However, data about the neuroprotective effects of sodium selenite (Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub>) on the activity of mitochondrial complexes and creatine kinase (mtCK) are scarce. Therefore, this study investigated the effects of the chronic exposure to Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> on brain energy metabolism and oxidative stress parameters in MeHg\u2010poisoned mice. Adult male mice were orally treated with MeHg (40 mg L<jats:sup>\u22121<\/jats:sup> in drinking water, <jats:italic>ad libitum<\/jats:italic>) during 21 days and simultaneously administrated with daily subcutaneous injections of Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> (5 \u03bcmol kg<jats:sup>\u22121<\/jats:sup>), a potential neuroprotectant. Mitochondrial complexes I to IV and mtCK activities were measured in cerebral cortex mitochondria. The cerebro\u2010cortical tissue was also used to evaluate the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GR) activities, as well as lipid peroxidation. Metal deposition was followed autometalographically (AMG). Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> partially prevented MeHg\u2010induced inhibition of complexes II\u2013III, IV and mtCK activities; however, it was unable to prevent MeHg\u2010induced complex I and II inhibition. MeHg increased lipid peroxidation, GR activity and decreased GPx activity in the cerebral cortex; however, Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> did not modify such events. Furthermore, Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub><jats:italic>per se<\/jats:italic> inhibited complexes I, II\u2013III and IV and mtCK activities and increased GPx and GR activities and lipid peroxidation. These data show that inorganic selenium was ineffective in preventing most of the MeHg\u2010induced brain biochemical alterations. However, the most prominent finding was the selenium\u2010induced reduction of cells labelled for metal deposition. Although, the literature supports the beneficial effects of selenium against mercury toxicity, the toxic effects elicited by Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub>, alone or in combination with mercury, should be considered when this compound is proposed as a potential protective therapy for MeHg poisoning.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2010.07.225","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T08:18:55Z","timestamp":1278663535000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Effects of inorganic selenium administration in methylmercury\u2010induced neurotoxicity in mouse cerebral cortex"],"prefix":"10.1002","volume":"28","author":[{"given":"Viviane","family":"Glaser","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bioenerg\u00e9tica e Estresse Oxidativo Departamento de Bioqu\u00edmica Centro de Ci\u00eancias 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