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We performed a retrospective analysis in a cohort of term infants who required intensive care (i) to investigate the incidence of abnormal white matter appearances on the magnetic resonance imaging obtained before 2 months corrected age, and (ii) to examine its relationships with other cerebral lesions, clinical backgrounds, and short\u2010term outcome at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>White matter appearances on T2\u2010weighted imaging (T2WI) and fluid\u2010attenuated inversion recovery imaging (FLAIR) were assessed in relationship with other cerebral lesions, clinical backgrounds, established white matter lesions on follow\u2010up scans, and abbreviated developmental outcomes at 12 months in 150 term\u2010born infants who were cared for at a tertiary neonatal intensive care unit with mixed indications for admission (positive pressure ventilation and intravenous inotropes required in 38% and 49% of infants respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On T2WI and FLAIR, 14.0% and 41.3% of infants showed abnormal white matter intensities respectively, which were both related with lesions in the internal capsule and deep grey matter. Abnormal T2WI appearances were correlated with low Apgar scores and low blood base\u2010excess whereas abnormal FLAIR appearances were associated with younger corrected age at scan. Follow\u2010up studies in a cohort of infants revealed that abnormal white matter intensities further correlated with chronic long\u2010T2 lesions after 8 months corrected age (<jats:italic>n<\/jats:italic> = 40) and severe neuro\u2010developmental disability at 12 months (<jats:italic>n<\/jats:italic> = 104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal white matter intensities were associated with pathological clinical variables. White matter injury may not be a specific form of cerebral damage in preterm infants. For the precise evaluation of newborn brain imaging, it may be beneficial to account for corrected age even in term infants.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2010.07.233","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T08:19:51Z","timestamp":1280477991000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Subtle white matter injury is common in term\u2010born infants with a wide range of risks"],"prefix":"10.1002","volume":"28","author":[{"given":"Sachiko","family":"Iwata","sequence":"first","affiliation":[{"name":"Centre for Developmental and Cognitive Neuroscience Department of Paediatrics and Child Health Kurume University School of Medicine Kurume Fukuoka Japan"},{"name":"Division of Neonatology Nagano Children's Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bainbridge","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Bio\u2010Engineering University College London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachio","family":"Takashima","sequence":"additional","affiliation":[{"name":"Yanagawa Institute for Developmental Disabilities International University of Health and Welfare Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyojiro","family":"Matsuishi","sequence":"additional","affiliation":[{"name":"Centre for Developmental and Cognitive Neuroscience Department of Paediatrics and Child Health Kurume University School of Medicine Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osuke","family":"Iwata","sequence":"additional","affiliation":[{"name":"Centre for Developmental and Cognitive Neuroscience Department of Paediatrics and Child Health Kurume University School of Medicine Kurume Fukuoka Japan"},{"name":"Division of Neonatology Nagano Children's Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336675"},{"key":"e_1_2_8_4_1","first-page":"533","article-title":"MR imaging MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy","volume":"27","author":"Barkovich A.J.","year":"2006","journal-title":"AJNR Am. 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