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Long\u2010lasting alterations in the structure and function of tissues and the neuroendocrine system, which are known as \u2018programming effects\u2019, increase the risks of these diseases. To investigate the pathophysiology of programming effects, several kinds of IUGR rodent models have been used in experiments. Sexual maturation and the onset of puberty are delayed in these models. We have previously reported that decreased action of hypothalamic kisspeptin, which is a positive regulator of GnRH, contributes to the delayed onset of puberty in undernutrition\u2010induced IUGR rats. The aim of this study was to evaluate whether the hypothalamic Kiss1\u2013Kiss1r\u2013GnRH system is also altered in dexamethasone\u2010induced IUGR rats. Compared with offspring from an untreated mother (control), offspring from a dexamethasone administered mother (DEX) showed a significant reduction in body weight throughout the experimental period (from birth to the prepubertal period) and the delayed onset of puberty. There were no significant differences between the control and DEX groups with regard to their hypothalamic <jats:italic>Kiss1<\/jats:italic>, <jats:italic>Kiss1r<\/jats:italic>, <jats:italic>GnRH<\/jats:italic>, <jats:italic>CRH<\/jats:italic>, <jats:italic>NPY<\/jats:italic> and <jats:italic>POMC<\/jats:italic> mRNA levels during the experimental period or their serum LH, FSH, or leptin concentrations at postnatal day 28 or vaginal opening (VO). Compared with the control, DEX showed significantly lower ovarian weight at postnatal day 28, but not at VO. These results suggested that the delayed onset of puberty induced by maternal dexamethasone administration would occur independently of hypothalamic Kiss1\u2013Kiss1r\u2013GnRH system.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2010.11.001","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T11:09:32Z","timestamp":1289560172000},"page":"183-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1\u2013Kiss1r\u2013GnRH system"],"prefix":"10.1002","volume":"29","author":[{"given":"Takeshi","family":"Iwasa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 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