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We have previously reported attenuated prepulse inhibition (PPI) of the startle reaction in adult female rats derived from dams exposed to chronic mild stress (CMS) during gestation. In humans, decreased PPI has been reported to be associated with anxiety. Because of its potential translational value across species, the modulation of startle reactivity may be a useful tool in examining altered emotional reactivity following prenatal insults. The present study aimed at investigating whether prenatally stressed male offspring would display altered startle phenotype. Stress was induced by maternal gestational exposure to alternating procedures, i.e. CMS. At the age of 3 months, half of the offspring were blood sampled under restraint. At the age of 6 months, i.e. three months later, all animals were tested in the acoustic startle and the light enhanced startle (LES) paradigm. Control and CMS male offspring showed similar basal startle and LES levels. Maternal gestational exposure to the relatively mild, variable paradigm of stressors affected the PPI response pattern in male rats. In prenatally manipulated males, the PPI response differed statistically significantly, depending on prior exposure to an episode of postnatal acute stress (blood sampling under restraint). In contrast, the PPI response in control males was unaffected by this postnatal experience. The present work supports the hypothesis that the maternal environment is a long\u2010term determinant of phenotypic differences in sensitivity to stressors.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.01.002","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T09:25:27Z","timestamp":1296120327000},"page":"495-500","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gestational chronic mild stress: Effects on acoustic startle in male offspring of rats"],"prefix":"10.1002","volume":"29","author":[{"given":"K.S.","family":"Hougaard","sequence":"first","affiliation":[{"name":"National Research Centre for the Working Environment Lers\u00f8 Parkall\u00e9 105 DK\u20102100 Copenhagen \u00d8 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.R.","family":"Mandrup","sequence":"additional","affiliation":[{"name":"National Food Institute Technical University of Denmark M\u00f8rkh\u00f8j Bygade 19 DK\u20102860 S\u00f8borg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment Lers\u00f8 Parkall\u00e9 105 DK\u20102100 Copenhagen \u00d8 Denmark"},{"name":"Centre for Psychiatric Research, Aarhus University Hospital Risskov Skovagervej 2 DK\u20108240 Risskov Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.B.","family":"B\u00f8gh","sequence":"additional","affiliation":[{"name":"Veterinary Reproduction and Obstetrics, Faculty of Life Sciences University of Copenhagen Dyrl\u00e6gevej 68 DK\u20101870 Frederiksberg C. 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