{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:57:10Z","timestamp":1792133830021,"version":"4.4.0"},"reference-count":90,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T00:00:00Z","timestamp":1299283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004792","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007382","name":"Fondation Motrice","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010076","name":"Conseil R\u00e9gional Provence-Alpes-C\u00f4te d'Azur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010842","name":"Temple University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early brain injury including white matter damage (WMD) appears strongly correlated to perinatal hypoxia\u2010ischemia and adverse neurological outcomes in preterm survivors. Indeed, WMD has been widely associated with subtle to major motor disturbances, sensory, behavioral and cognitive impairments in preterm infants who afterward develop cerebral palsy (CP). Prenatal ischemia (PI) has been shown to reproduce the main features of WMD observed in preterm infants. The present study was aimed at determining in adult rats the impact of PI on brain axons, musculoskeletal histology and locomotor activity. PI was induced by unilateral intrauterine artery ligation at E17 in pregnant rats. We found axonal degeneration and reactive astrogliosis in several white matter regions of adult PI rats. We found mild myopathic and secondary joint changes, including increased variability in myofiber size in several hind limb muscles, decreased myofibers numbers but increased Pax 7 cells and myofiber size in the gastrocnemius, and mild knee and ankle chondromalacia. Although treadmill locomotion appeared normal, several kinematic parameters, such as stride length, amplitude, velocity and leg joint angles were altered in adult PI rats compared to shams. Using intra\u2010 and inter\u2010group variability of kinematic parameters, PI seemed to impair the maturation of locomotion on the treadmill. In addition, PI rats exhibited spontaneous hyperactivity in open\u2010field test. Musculoskeletal changes appeared concomitant with mild impairments in gait and posture. Our rodent model of WMD based on PI reproduces the mild motor deficits and musculoskeletal changes observed in many preterm infants with a perinatal history of hypoxia\u2010ischemia, and contributes towards a better understanding of the interplay between brain injury, musculoskeletal histopathology and gait disturbances encountered subsequently.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.02.010","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T04:21:35Z","timestamp":1299558095000},"page":"593-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mild musculoskeletal and locomotor alterations in adult rats with white matter injury following prenatal ischemia"],"prefix":"10.1002","volume":"29","author":[{"given":"Maxime","family":"Delcour","sequence":"first","affiliation":[{"name":"UMR 6149 Neurosciences Int\u00e9gratives et Adaptatives, CNRS, Aix\u2010Marseille Universit\u00e9, Centre Saint Charles case B, 3 place Victor Hugo 13331 Marseille Cedex 03 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Russier","sequence":"additional","affiliation":[{"name":"UMR 6149 Neurosciences Int\u00e9gratives et Adaptatives, CNRS, Aix\u2010Marseille Universit\u00e9, Centre Saint Charles case B, 3 place Victor Hugo 13331 Marseille Cedex 03 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong L.","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Temple University Philadelphia PA 19140 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky S.","family":"Massicotte","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia PA 19140 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia PA 19140 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques\u2010Olivier","family":"Coq","sequence":"additional","affiliation":[{"name":"UMR 6149 Neurosciences Int\u00e9gratives et Adaptatives, CNRS, Aix\u2010Marseille Universit\u00e9, Centre Saint Charles case B, 3 place Victor Hugo 13331 Marseille Cedex 03 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00380.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.10.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)01997-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/2-287-27822-2_7"},{"key":"e_1_2_8_7_1","volume-title":"The Satellite Cell and Muscle Regeneration, Myology","author":"Bischoff R.","year":"1994"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199911)216:3<244::AID-DVDY3>3.0.CO;2-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1523\/JNEUROSCI.20-14-05538.2000","article-title":"Perinatal distress leads to lateralized medial prefrontal cortical dopamine hypofunction in adult rats","volume":"20","author":"Brake W.G.","year":"2000","journal-title":"J. Neurosci."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02226924"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.07.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e31819224d"},{"key":"e_1_2_8_13_1","first-page":"223","article-title":"Pathology of spastic muscle in cerebral palsy","volume":"142","author":"Castle M.E.","year":"1979","journal-title":"Clin. Orthop. Relat. Res."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(97)00569-X"},{"key":"e_1_2_8_15_1","unstructured":"J.O.Coq M.Delcour P.Olivier C.Chambon M.Russier J.Pansiot Y.Tseng B.Alescio\u2010Lautier M.Barbe O.Baud Prenatal ischemia induces cognitive deficits slight locomotion impairments and spastic muscles and a cortical degradation of S1 but not M1 maps in rats.Soc. Neurosci. Abstr. Chicago 2009."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.10.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn268"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2004.10.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090062"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00097.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(00)00065-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.12-1429"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1216"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.06.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2816-03.2004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21095"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600333"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4983-04.2005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20051"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.104"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.10.006"},{"key":"e_1_2_8_32_1","volume-title":"The Identification and Treatment of Gait Problems in Cerebral Palsy","author":"Gage J.R.","year":"2009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.032"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.10.002"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.05.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.04.009"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2008.09.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01652.x"},{"issue":"1","key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1177\/0883073803018001S0501","article-title":"Neuroimaging in spasticity and movement disorders","volume":"18","author":"Hoon A.H.","year":"2003","journal-title":"J. Child Neurol."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03306.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14466-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809337920"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1961.0001"},{"key":"e_1_2_8_44_1","volume-title":"A Physiological Approach to Clinical Neurology","author":"Lance J.W.","year":"1981"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60380-3"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.06.019"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00394-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.042"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.9.2.493"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03308.2003"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0647-0"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.05.010"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.2.g02mr19257"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90124-X"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03711.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.01.001"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000187052.81889.57"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.119.4.933"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2009.06.001"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.04.027"},{"key":"e_1_2_8_61_1","first-page":"1","article-title":"L'autonomie et la centralisation dans le syst\u00e8me nerveux des animaux","volume":"7","author":"Phillipson M.","year":"1905","journal-title":"Trav. Lab. Physio. Inst. Solvay"},{"key":"e_1_2_8_62_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.clinbiomech.2007.08.003","article-title":"Co\u2010contraction during passive movements of the knee joint in children with cerebral palsy","volume":"22","author":"Pierce S.R.","year":"2007","journal-title":"Clin. Biomech. (Bristol, Avon)"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070331"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.11.016"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10182-3"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.03.001"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090161"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp281"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl236"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.10.024"},{"key":"e_1_2_8_71_1","first-page":"87","article-title":"Histological and morphological aspects of muscle in infantile cerebral palsy","volume":"15","author":"Romanini L.","year":"1989","journal-title":"Ital. J. Orthop. Traumatol."},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100120603"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb15461.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21689"},{"key":"e_1_2_8_75_1","first-page":"8","article-title":"A report: the definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum P.","year":"2007","journal-title":"Dev. Med. Child Neurol. Suppl."},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200209000-00024"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687615"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20060"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1924"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42206"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.024"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(95)00895-9"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085978"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70294-1"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1267-7"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1346"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700880102"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03105.x"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.08.217"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20977"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181e00c80"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574811000256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574811000256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2011.02.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2011.02.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2011.02.010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2011.02.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:46:51Z","timestamp":1694015211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2011.02.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,5]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1016\/j.ijdevneu.2011.02.010"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2011.02.010","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,5]]},"assertion":[{"value":"2010-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}