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Exposure to high concentrations of oxygen, however, may worsen oxidative stress induced by ischemic injury. In this study we investigated the short\u2010 and long\u2010term behavioral outcomes in rats that had undergone hypoxic\u2013ischemic brain injury on postnatal day 7, followed by 2 h exposure to 21%, 40%, or 100% oxygen, compared to normal controls. There were no differences in the development of walking, head lifting and righting reflexes from postnatal days 9 to 15. Cliff avoidance showed some abnormal responses in the H21 animals. From postnatal days 28 to 56, three tests of sensorimotor coordination were performed weekly: ledged tapered beam, cylinder, and bilateral tactile stimulation. The ledged tapered beam test without prior training of animals was sensitive to injury, but did not distinguish between treatment groups. The cylinder test showed a greater use of the unimpaired limb in female 21% and 40% oxygen groups compared to controls. Performance in both cylinder and the beam tests showed a correlation with the degree of brain injury. The bilateral tactile stimulation test showed that the male 21% oxygen groups had worse sensory asymmetry than male 40% or 100% oxygen groups, but was not statistically significantly different from controls.<\/jats:p><jats:p>We thus found a minor benefit to post\u2010hypoxia\u2013ischemic treatment with 100% and 40% oxygen compared to 21% in one test of early motor skills. Our results for long\u2010term sensorimotor behavior, however, showed conflicting results, however, as males treated with 40% or 100% oxygen had less sensory asymmetry (better performance) in the bilateral tactile stimulation test than males treated with 21% oxygen, while females had impaired motor performance in the cylinder test with both 21% and 40% oxygen.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T17:03:18Z","timestamp":1305910998000},"page":"629-638","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Short\u2010 and long\u2010term behavioral effects of exposure to 21%, 40% and 100% oxygen after perinatal hypoxia\u2013ischemia in the rat"],"prefix":"10.1002","volume":"29","author":[{"given":"K. Nina","family":"Woodworth","sequence":"first","affiliation":[{"name":"Department of Pathology Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road, L113 Portland OR 97239\u20103098 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Palmateer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road, UHS\u20102 Portland OR 97239\u20103098 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Swide","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road, UHS\u20102 Portland OR 97239\u20103098 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie R.","family":"Grafe","sequence":"additional","affiliation":[{"name":"Department of Pathology Oregon Health &amp; 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